Magic bullets, magic shields, and antimicrobials in between

Prathapan, Praveen

doi:10.1016/j.pscia.2022.100002

Cited by 2 publications

(2 citation statements)

References 246 publications

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“…On the other hand, due to the limited availability of general practitioners, who, for objective or subjective reasons, do not pay enough attention to the patient, side effects of drugs are often treated as new ailments [4,10,11]. Patients who usually use several drugs and who often experience side effects, without recognizing them, take new drugs on their own initiative, which will contribute to the appearance of new side effects and so on [19].…”

Section: Discussionmentioning

confidence: 99%

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The knowledge and attitude of patients about drugs they use

Vasović,

Prodanović

et al. 2023

Hosp Pharm Int Multi J

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Introduction: Although numerous effective drugs are available on the market, the effects of the therapy are often missing. Possible reasons include problems with access to health care, lack of compliance or a tendency to self-medicate. Aim: The aim of the study was to analyze the structure of the drugs dispensed to patients in the pharmacy, as well as the knowledge and attitudes of patients towards the drugs they use. Material and Methods: Research has been conducted in 2 pharmacies-pharmacy "Galenpharm" and pharmacy "Janković" in Kula, during 10 working days, 3 hours each day at randomly selected terms during March 2023. The number and type of drugs dispensed were recorded, and the respondents were interviewed according to a questionnaire prepared in advance. Results: During the observed period, the largest number of drugs dispensed was from the group of drugs used for the treatment of disorders of the cardiovascular system. In 89% of cases, patients take medicines according to the doctor's recommendation. Patient's knowledge about the correct use of medications, dosing and taking them in relation to meals is satisfactory. The knowledge about side effects of drugs and possible interactions is minimal, although over 90% of respondents read the instructions for the drug from the original packaging of the drugs. Conclusion: Patient's knowledge about the drugs they take is limited. By not taking medications correctly, patients are undertreated, regardless of the correct diagnosis and well-chosen medications. Their knowledge about drugs is a stumbling block in successful pharmacotherapy.

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Section: Discussionmentioning

confidence: 99%

“…Significant moments in modern medicine include the discovery of antibacte-rial drugs [2], with Paul Ehrlich's introduction of the term "magic bullet" to target diseasecausing microorganisms specifically [3,4]. Antibacterial drugs reduced infectious disease mortality rates and increased life expectancy.…”

Section: Introductionmentioning

confidence: 99%

The knowledge and attitude of patients about drugs they use

Vasović,

Prodanović

et al. 2023

Hosp Pharm Int Multi J

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Precision Drug Delivery to Tackle Antibiotic Resistance

Durgapal,

Joshi,

Pandey

et al. 2024

Advances in Medical Diagnosis, Treatment, and Care

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The global emergence of antibacterial resistance poses a severe threat to human life, echoing Alexander Fleming's cautionary prediction about the misuse of antibiotics. In the current era, many existing antibacterials are increasingly losing effectiveness against various microorganisms. Overuse and suboptimal exposure provide fertile ground for microbial thriving and the development of resistance through mechanisms like cell membrane protection, target modification, enzymatic inactivation, and drug efflux. Conventional drug delivery systems struggle against this evolving bacterial resistance. Consequently, there's a pressing need for innovative strategies to combat antibacterial drug resistance. Nanotechnology-based targeted drug delivery systems offer a promising solution. These systems enhance drug solubility, permeability, bioavailability, stability, and efficacy while minimizing toxicity. This chapter explores the concept of targeted drug delivery to address antibacterial resistance, focusing on mechanisms, approaches, and recent advancements.

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Magic bullets, magic shields, and antimicrobials in between

Cited by 2 publications

References 246 publications

The knowledge and attitude of patients about drugs they use

The knowledge and attitude of patients about drugs they use

Precision Drug Delivery to Tackle Antibiotic Resistance

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