Magnaporthe oryzae MoNdt80 is a transcriptional regulator of GlcNAc catabolic pathway involved in pathogenesis

Bhatt, Dharmendra Nath; Ansari, Sekhu; Kumar, Anil; Ghosh, Sumit; Narula, Alka; Datta, Asis

doi:10.1016/j.micres.2020.126550

Cited by 10 publications

(5 citation statements)

References 47 publications

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“…They proposed that GlcNAc supports fungus by the antioxidant defense to astounded oxidative stress inside its host, while in the impaired catabolic pathway, GlcNAc becomes toxic to the M. oryzae [ 65 ]. In line with this work, Bhatt et al acknowledged a conserved transcriptional regulator, Ndt80/PhoG , in GlcNAc catabolic gene cluster in various fungi, including M. oryzae [ 64 ]. Interestingly, it was reported that MoNdt80 is indispensable for GlcNAc utilization and successful colonization and pathogenesis of M. oryzae in its host [ 64 ].…”

Section: Glcnac Metabolic Engineering For Reducing the Virulence Of P...mentioning

confidence: 76%

“…In line with this work, Bhatt et al acknowledged a conserved transcriptional regulator, Ndt80/PhoG , in GlcNAc catabolic gene cluster in various fungi, including M. oryzae [ 64 ]. Interestingly, it was reported that MoNdt80 is indispensable for GlcNAc utilization and successful colonization and pathogenesis of M. oryzae in its host [ 64 ]. Other studies also support the role of GlcNAc metabolism (in planta and in vitro) in Xanthomonas campestris , a causal agent of black rot disease on Brassica [ 102 , 103 , 104 ].…”

Section: Glcnac Metabolic Engineering For Reducing the Virulence Of P...mentioning

confidence: 76%

“…The genes of the GlcNAc catabolic pathway have been identified in human bacterial pathogens such as Mycobacterium , Vibrio cholerae , yeast ascomycetes, filamentous ascomycetes, basidiomycetes and zygomycetes fungi, and protozoan parasites [ 1 , 4 , 52 , 63 ]. Similarly, the genes involved in GlcNAc utilization are identified in the genomes of several phytopathogenic fungi, including M. grisea , Gibberella zeae, Ustilago maydis , Sclerotinia sclerotiorum, , Botryotinia fuckeliana , Pyrenophora tritici-repentis , Cochliobolus heterostrophus , Mycosphaerella fijiensis , Nectria haematococca , and Aspergillus niger [ 64 , 65 ]. This unique nature of the GlcNAc catabolic pathway suggests an important role of the gene cluster in pathogenesis.…”

Section: Universality Of Glcnac Catabolic Pathway and Genes In Human ...mentioning

confidence: 99%

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N-Acetylglucosamine Sensing and Metabolic Engineering for Attenuating Human and Plant Pathogens

et al. 2022

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During evolution, both human and plant pathogens have evolved to utilize a diverse range of carbon sources. N-acetylglucosamine (GlcNAc), an amino sugar, is one of the major carbon sources utilized by several human and phytopathogens. GlcNAc regulates the expression of many virulence genes of pathogens. In fact, GlcNAc catabolism is also involved in the regulation of virulence and pathogenesis of various human pathogens, including Candida albicans, Vibrio cholerae, Leishmania donovani, Mycobacterium, and phytopathogens such as Magnaporthe oryzae. Moreover, GlcNAc is also a well-known structural component of many bacterial and fungal pathogen cell walls, suggesting its possible role in cell signaling. Over the last few decades, many studies have been performed to study GlcNAc sensing, signaling, and metabolism to better understand the GlcNAc roles in pathogenesis in order to identify new drug targets. In this review, we provide recent insights into GlcNAc-mediated cell signaling and pathogenesis. Further, we describe how the GlcNAc metabolic pathway can be targeted to reduce the pathogens’ virulence in order to control the disease prevalence and crop productivity.

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Section: Glcnac Metabolic Engineering For Reducing the Virulence Of P...mentioning

confidence: 76%

Section: Glcnac Metabolic Engineering For Reducing the Virulence Of P...mentioning

confidence: 76%

Section: Universality Of Glcnac Catabolic Pathway and Genes In Human ...mentioning

confidence: 99%

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N-Acetylglucosamine Sensing and Metabolic Engineering for Attenuating Human and Plant Pathogens

et al. 2022

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“… 31 Redirecting resources to the infection sites and giving priority to the carbon allocation to the pathogen-affected regions are key components of the adaptive response. 49 , 50 The stimulation of defense mechanisms is intimately linked to this reallocation of carbon resources. The plant helps the body fight the invasive pathogen by increasing the manufacture of hormones and defense-related substances like phytoalexins and antimicrobial proteins.…”

Section: Introductionmentioning

confidence: 99%

The link between changing in host carbon allocation and resistance to Magnaporthe oryzae : a possible tactic for mitigating the rice blast fungus

Mmbando

2024

Plant Signaling & Behavior

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One of the most destructive diseases affecting rice is rice blast, which is brought on by the rice blast fungus Magnaporthe oryzae . The preventive measures, however, are not well established. To effectively reduce the negative effects of rice blasts on crop yields, it is imperative to comprehend the dynamic interactions between pathogen resistance and patterns of host carbon allocation. This review explores the relationship between variations in carbon allocation and rice plants’ ability to withstand the damaging effects of M. oryzae . The review highlights potential strategies for altering host carbon allocation including transgenic, selective breeding, crop rotation, and nutrient management practices as a promising avenue for enhancing rice blast resistance. This study advances our knowledge of the interaction between plants’ carbon allocation and M. oryzae resistance and provides stakeholders and farmers with practical guidance on mitigating the adverse effects of the rice blast globally. This information may be used in the future to create varieties that are resistant to M. oryzae .

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“…Previous studies have also indicated that disruption of the GlcNAc utilization pathway leads to attenuated virulence in mouse model candidacies. GlcNAc catabolism has also been shown to be important for colonization and establishing virulence inside the host, in several pathogens, including Vibrio cholerae [23], Magnaporthe oryzae [24], and Leishmania donovani [25]. Nevertheless, the functional significance of several metabolic enzymes involved in the formation of metabolic intermediates remains elusive.…”

Section: Introductionmentioning

confidence: 99%

Metabolic and Phenotypic Changes Induced during N-Acetylglucosamine Signalling in the Fungal Pathogen Candida albicans

et al. 2023

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The human commensal yeast Candida albicans is pathogenic and results in a variety of mucosal and deep tissue problems when the host is immunocompromised. Candida exhibits enormous metabolic flexibility and dynamic morphogenetic transition to survive under host niche environmental conditions and to cause virulence. The amino sugar N-acetylglucosamine (GlcNAc) available at the host infection sites, apart from acting as an extremely good carbon and nitrogen source, also induces cellular signalling in this pathogen. In C. albicans, GlcNAc performs multifaceted roles, including GlcNAc scavenging, GlcNAc import and metabolism, morphogenetic transition (yeast—hyphae and white—opaque switch), GlcNAc-induced cell death (GICD), and virulence. Understanding the molecular mechanism(s) involved in GlcNAc-induced cellular processes has become the main focus of many studies. In the current study, we focused on GlcNAc-induced metabolic changes associated with phenotypic changes. Here, we employed gas chromatography–mass spectrometry (GC–MS), which is a high-throughput and sensitive technology, to unveil global metabolomic changes that occur in GlcNAc vs. glucose grown conditions in Candida cells. The morphogenetic transition associated with metabolic changes was analysed by high-resolution field emission scanning electron microscopy (FE-SEM). Metabolite analysis revealed the upregulation of metabolites involved in the glyoxylate pathway, oxidative metabolism, and fatty acid catabolism to probably augment the synthesis of GlcNAc-induced hypha-specific materials. Furthermore, GlcNAc-grown cells showed slightly more sensitivity to amphotericin B treatment. These results all together provide new insights into the development of antifungal therapeutics for the control of candidiasis in humans.

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Magnaporthe oryzae MoNdt80 is a transcriptional regulator of GlcNAc catabolic pathway involved in pathogenesis

Cited by 10 publications

References 47 publications

N-Acetylglucosamine Sensing and Metabolic Engineering for Attenuating Human and Plant Pathogens

N-Acetylglucosamine Sensing and Metabolic Engineering for Attenuating Human and Plant Pathogens

The link between changing in host carbon allocation and resistance to Magnaporthe oryzae : a possible tactic for mitigating the rice blast fungus

Metabolic and Phenotypic Changes Induced during N-Acetylglucosamine Signalling in the Fungal Pathogen Candida albicans

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