Magnesium-28 Studies in Lambs

McAleese, Dermot; Bell, M. C.; Forbes, R. M.

doi:10.1093/jn/74.4.505

Cited by 33 publications

(14 citation statements)

References 10 publications

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“…In the present studies reductions in serum Mg from 22 to 68% of control values also paralleled the decreases in dietary Mg. Similar results have been reported with hens and other species (McAleese et al, 1961;Hajj and Sell, 1969;McNeill et al, 1982).…”

Section: Figure 2 Effect Of Mg-deficient Diets On Serumsupporting

confidence: 91%

Growth, Thyroid Function, and Serum Macromineral Levels in Magnesium-Deficient Chicks

1992

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Growth and thyroid function were studied in Mg-deficient chicks. Dietary levels of 80 to 315 ppm Mg were compared with control levels of 578 to 787 ppm Mg. Signs of Mg deficiency appeared rapidly and acutely within 2 to 5 days at dietary levels of 250 to 260 ppm or lower. Growth and feed intake decreased progressively as the deficiency became more severe. Control chicks pair-fed with the deficient chicks gained significantly more weight. Serum Mg decreased at all levels of Mg below control, but at 260 and 315 ppm it returned to control values after 21 days on treatment. Serum Ca diminished only when dietary Mg was 250 ppm or less. Serum K increased in severely deficient chicks but decreased over time in milder deficiencies. Thyroid gland weights were unchanged. However, very young chicks fed a Mg-deficient diet had lower serum 3,5,3'-triiodothyronine (T3) whereas serum thyroxine (T4) was generally unaffected. Beyond 1 wk of age chicks that had prior access to a Mg-sufficient diet had low serum T4 levels whereas serum T3 was unchanged. Therefore, peripheral thyroid hormone metabolism is altered in a Mg deficiency, but this effect is dependent on the age at which the deficiency occurs.

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Section: Figure 2 Effect Of Mg-deficient Diets On Serumsupporting

confidence: 91%

Growth, Thyroid Function, and Serum Macromineral Levels in Magnesium-Deficient Chicks

1992

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“…In man, Graham et al (1960) have noted this decrease in percentage magnesium absorption with increase in dietary magnesium intake. McAleese, Bell & Forbes (1961) have noticed a greater absorption of magnesium by magnesium-deficient lambs than by normal specimens. Also Smith (1962), working with calves, found that the true percentage absorption of magnesium from the digestive tract proximal to the caecum decreased with increase in magnesium intake.…”

Section: Discussionmentioning

confidence: 95%

In vivo transport of magnesium and other cations across the wall of the gastro‐intestinal tract of sheep

Care¹,

Klooster²

1965

The Journal of Physiology

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“…In conclusion, balance data in sheep (McAleese et al 1961;Allsop & Rook, 1979) demonstrated that the apparent digestibility of magnesium in sheep is influenced by the blood magnesium concentration. The data of the present study do not support the assumption that this modulation of magnesium absorption occurs in the rumen.…”

Section: Discussionmentioning

confidence: 88%

“…Therefore, it is very unlikely that the net absorption of magnesium from the rumen is influenced by physiological variations in plasma magnesium concentration. McAleese et al (1961) and Allsop & Rook (1979) observed that a low magnesium intake (hypomagnesaemia) increased, and hypermagnesaemia decreased, the net rate of absorption of magnesium from the entire gastrointestinal tract of sheep. Our findings do not support the assumption that these alterations result from a change in the rate of absorption of magnesium from the rumen.…”

Section: Discussionmentioning

confidence: 97%

“…The absorption of magnesium, however, increased in rats (Chutkow, 1965;Greene, Bratton, Zmudzki, Schelling & Byers, 1986) and in lambs (McAleese, Bell & Forbes, 1961) fed diets low in magnesium. In sheep, Allsop & Rook (1979) raised the blood magnesium concentration by an intravenous magnesium infusion and observed that the net absorption of magnesium from the gastrointestinal tract was depressed at high plasma magnesium concentrations.…”

Section: Introductionmentioning

confidence: 99%

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Magnesium Absorption From the Temporarily Isolated Rumen of Sheep: No Effect of Hyper‐ or Hypomagnesaemia

Martens

Stossel

1988

Exp Physiol

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SUMMARYThe net absorption of magnesium from the temporarily isolated rumen of sheep was measured at different plasma magnesium concentrations. In the first series of experiments, the plasma magnesium concentration was raised from 0-89 + 0-11 to 1-97 + 027 mmol 1-1 by intravenous infusion of MgCl2 immediately before measurement of magnesium absorption. In a second series absorption of magnesium was studied over 20 h after the beginning of a continuous intravenous infusion of magnesium, which led to hypermagnesaemic levels of 2-78 + 0 59 mmol 1-1. In the third series sheep were fed a magnesium-deficient diet which caused a significant decrease of plasma magnesium concentration from 0-96 + 0-06 to 0 50 + 0-06 mmol 1-1. Neither hyper-nor hypomagnesaemia changed net absorption of magnesium from the rumen of sheep. It is concluded that the active ttansport of magnesium from the rumen was not influenced by the plasma magnesium concentration and that any passive and paracellular movement of magnesium through the rumen wall must have been negligibly small under the conditions of these experiments.

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Magnesium-28 Studies in Lambs

Cited by 33 publications

References 10 publications

Growth, Thyroid Function, and Serum Macromineral Levels in Magnesium-Deficient Chicks

Growth, Thyroid Function, and Serum Macromineral Levels in Magnesium-Deficient Chicks

In vivo transport of magnesium and other cations across the wall of the gastro‐intestinal tract of sheep

Magnesium Absorption From the Temporarily Isolated Rumen of Sheep: No Effect of Hyper‐ or Hypomagnesaemia

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