Magnesium and Cardiac Surgery in the Critical Care Setting

Carrio, Maria L.; López-Delgado, Juan Carlos; Javierre, Casimiro; Torrado, Herminia; Farrero, Eva; Ritchie, David; Ventura, Josep L.

doi:10.1007/978-1-4614-7836-2_138

Cited by 2 publications

(2 citation statements)

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“…It acts as a cofactor of the energy source for contractility, adenosine-triphosphatase, and protects the myocardium against ischemic reperfusion injury [ 6 , 7 ] . Serum magnesium concentration decreases after cardiac surgery, which is usually normalized after 3 to 5 days [ 8 ] .…”

Section: Discussionmentioning

confidence: 99%

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Comparison of the Efficacy of Oral versus Intravascular Magnesium in the Prevention of Hypomagnesemia and Arrhythmia after CABG

Jannati¹,

Shahbazi²,

Eshaghi³

2018

Braz J Cardiovasc Surg

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ObjectiveCardiac arrhythmias are a common challenge following open-heart surgeries. Hypomagnesemia is believed to be correlated with this condition. Prophylactic intravenous magnesium supplementation has been practiced for a long time in patients undergoing CABG. This study was designed in an attempt to compare the efficacy of oral versus intravenous routes in the prevention of hypomagnesemia and arrhythmia.MethodsIn this interventional clinical study, 82 patients were randomly assigned to 2 groups. All patients were evaluated for baseline serum magnesium level and arrhythmias. One group received 1,600 mg of oral magnesium hydroxide through nasogastric (NG) tube prior to surgery, while the other group received 2 g of magnesium sulfate during the induction of anesthesia. The serum magnesium level was monitored for 48 hours after the operation. The difference in preoperative hypomagnesemia was non-significant (Sig: 0.576).ResultsDuring the operation, the serum magnesium level peaked around 4 mg/dL, and no hypomagnesemia was detected in any patient. Although the curve of oral group declined parallel and below that of intravenous (IV) group, no significant differences were detected during postoperative monitoring. In addition, a prevalence of arrhythmia of 13.9% and 6.5% was noticed in IV and oral groups, respectively (OR: 0.428).ConclusionProviding 1,600 mg of oral magnesium supplement to patients is as effective as 2,000 mg of magnesium sulfate IV in preventing hypomagnesemia and arrhythmia after CABG. Thus, the authors introduce this treatment regimen as a promising and cost-effective method.

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Section: Discussionmentioning

confidence: 99%

“…This deficiency leads to cardiovascular clinical manifestations such as hypertension and electrocardiogram (ECG) changes, as well as supraventricular and ventricular arrhythmias [ 8 ] . Several mechanisms have been proposed regarding the role of magnesium deficiency in postoperative AF, but no clear explanation has been fully agreed upon.…”

Section: Discussionmentioning

confidence: 99%