Magnesium and its alloys as orthopedic biomaterials: A review

Staiger, Mark P.; Pietak, Alexis; Huadmai, Jerawala; Dias, George J.

doi:10.1016/j.biomaterials.2005.10.003

Cited by 3,998 publications

(2,555 citation statements)

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“…Among all possible candidates, magnesium alloys attract considerable attention due to their desirable mechanical and biodegradation properties. During the last decades, researchers have shown increasing interest towards magnesium as a potential biodegradable material for bone and cartilage tissue engineering [29,40]. In terms of mechanical properties, magnesium alloys show better characteristics than biodegradable polymers such as…”

Section: Mechanical Propertiesmentioning

confidence: 99%

“…Some physical properties of the Mg alloys, such as high specific strength and elastic modulus, are closer to those of the natural human bone compared to other traditional metal implants [27,28]. For example, compared to titanium alloys with the elastic modulus of 110-117 GPa, Mg alloys have lower modulus (41-45 GPa) leading to a decreased stress-shielding effect [29,30]. Moreover, Mg alloys are 3-16 times stronger than biopolymers and, at the same time, they are more ductile compared to bioceramics, which can reduce the chance of the device fracturing throughout the implantation process.…”

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confidence: 99%

“…In contrast to inert materials such as PLA, the increase in bone formation and decrease in healing time observed with magnesium implants indicates the potential osteoconductivity and bioactivity of magnesium [29,35]. The Osteoconductivity of magnesium is induced by the precipitation of calcium phosphate on the surface of the implants in an in vitro environment due to corrosion [86,87].…”

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confidence: 99%

“…Biomimetic calcium phosphate coatings enhance osteoblast response, impart osteoconductive capacity, and reduce the healing time for bone defects. Moreover, enhanced cell attachment and ingrowth due to calcium phosphate precipitation can lead to reduced corrosion rate [29].…”

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confidence: 99%

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Porous magnesium-based scaffolds for tissue engineering

Yazdimamaghani

Razavi

Vashaee

et al. 2017

Materials Science and Engineering: C

241

115

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Section: Mechanical Propertiesmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Porous magnesium-based scaffolds for tissue engineering

Yazdimamaghani

Razavi

Vashaee

et al. 2017

Materials Science and Engineering: C

241

115

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“…Among the most promising approaches, towards stable and effective composite scaffolds, it is important to note the combination of: a) phase separation or leaching processes, normally for obtaining the soft chondral phase, with b) computer aided rapid prototyping technologies based on addi tive manufacturing, usually for manufacturing the rigid bony phase [34]. In spite of the very positive results shown by metallic rapid prototyped prostheses and scaffolds for bone repair [35], most successful composite scaffolds for osteochondral repair are based on polymer ceramic com posites [31,34,36], polymer polymer composites [37], ceramic ceramic composites [38], ceramic metal composites [39] and metal metal composites [40]. Interestingly, metal polymer composites, which could benefit from the stiffness of metals for the bony phase and from the elasticity of polymers for the chondral phase are not so common.…”

Section: Introductionmentioning

confidence: 99%

Composite scaffolds for osteochondral repair obtained by combination of additive manufacturing, leaching processes and hMSC-CM functionalization

Lantada

Iniesta

García–Ruiz

2016

Materials Science and Engineering: C

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A b s t r a c tArticular repair is a relevant and challenging area for the emerging fields of tissue engineering and biofabrication. The need of significant gradients of properties, for the promotion of osteochondral repair, has led to the develop ment of several families of composite biomaterials and scaffolds, using different effective approaches, although a perfect solution has not yet been found. In this study we present the design, modeling, rapid manufacturing and in vitro testing of a composite scaffold aimed at osteochondral repair. The presented composite scaffold stands out for having a functional gradient of density and stiffness in the bony phase, obtained in titanium by means of computer aided design combined with additive manufacture using selective laser sintering. The chondral phase is obtained by sugar leaching, using a PDMS matrix and sugar as porogen, and is joined to the bony phase during the polymerization of PDMS, therefore avoiding the use of supporting adhesives or additional intermediate layers. The mechanical performance of the construct is biomimetic and the stiffness values of the bony and chondral phases can be tuned to the desired applications, by means of controlled modifications of different parameters. A human mesenchymal stem cell (h MSC) conditioned medium (CM) is used for improving scaffold response. Cell culture results provide relevant information regarding the viability of the composite scaffolds used.

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Intermetallics

Sauthoff

2006

Ullmann's Encyclopedia of Industrial Chemistry

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The article contains sections titled: 1. Introduction 1.1. Definition of Intermetallics 1.2. Historical Remarks 2. General Considerations 2.1. Crystal Structure and Compound Stability 2.2. Basic Properties 2.3. Criteria for Compound Selection 3. Magnetic Materials 3.1. AlNiCo Alloys 3.2. FeCo Alloys 3.3. Sendust Alloy 3.4. Laves Phases 3.5. Rare‐Earth Compounds 4. Superconducting Materials 4.1. Laves Phases 4.2. A15 Compounds 4.2.1. V 3 Si 4.2.2. V 3 Ga 4.2.3. Nb 3 Sn 4.2.4. Nb 3 Al 4.2.5. Nb 3 Si 5. Electronic Materials 5.1. Silicides 5.2. Other Compounds 6. Electric Materials 7. Thermoelectric and Thermomagnetic Materials 7.1. Silicides 7.2. Other Thermoelectric Compounds 7.3. Thermomagnetic Compounds 8. Optical Materials 9. Hydrogen‐Storage Materials 9.1. B2 Compounds 9.2. Laves Phases 9.3. Rare Earth Metal Compounds and Other Phases 10. Electrode Materials 10.1. Mg 2 Ni Alloys 10.2. Laves Phase Alloys 10.3. RNi 5 Alloys 11. Coating Materials 11.1. Aluminides 11.2. Silicides 12. Shape‐Memory Materials 12.1. Cu‐Base Alloys 12.1.1. Cu ‐ Zn ‐ Al Shape Memory Alloys 12.1.2. Cu ‐ Al ‐ Ni Shape‐Memory Alloys 12.2. NiAl Alloys 12.3. NiTi Alloys 13. Medical Biomaterials 14. Dental Materials 14.1. Amalgams 14.2. Cu ‐ Au Alloys 15. Wear‐Resistant Materials 16. Structural High‐Temperature Materials 16.1. Titanium Aluminide Alloys 16.1.1. Ti 3 Al Alloys 16.1.2. TiAl Alloys 16.2. Iron Aluminide Alloys 16.2.1. Fe 3 Al Alloys 16.2.2. FeAl Alloys 16.3. Nickel Aluminide Alloys 16.3.1. Ni 3 Al alloys 16.3.2. NiAl Alloys 16.4. Silicide Alloys

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Magnesium and its alloys as orthopedic biomaterials: A review

Cited by 3,998 publications

References 48 publications

Porous magnesium-based scaffolds for tissue engineering

Porous magnesium-based scaffolds for tissue engineering

Composite scaffolds for osteochondral repair obtained by combination of additive manufacturing, leaching processes and hMSC-CM functionalization

Intermetallics

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