Magnesium/Calcium Ratio in Urine of Patients With Renal Stones

Oreopoulos, D. G.; Soyannwo, M. A. O.; McGeown, Mary G.

doi:10.1016/s0140-6736(68)90464-9

Cited by 42 publications

(10 citation statements)

References 9 publications

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“…The Ca/Mg ratio is considered to be of a higher prognostic value for stone formation than the absolute calcium and magnesium concentrations [9,18]. A relative calcium excess, as well as a relative magnesium deficiency in the urine are recognized more easily.…”

Section: Discussionmentioning

confidence: 99%

Urinary factors of kidney stone formation in patients with Crohn's disease

et al. 1988

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An increased frequency of kidney stone formation is reported in patients with inflammatory bowel disease. In order to investigate its pathogenesis, the concentrations of factors known to enhance calcium oxalate stone formation (oxalate, calcium, uric acid) as well as of inhibitory factors for nephrolithiasis (magnesium, citrate) were determined in the urine of 86 patients with Crohn's disease and compared with those of 53 metabolically healthy controls. Six patients with Crohn's disease already had experienced calcium oxalate nephrolithiasis. Patients with Crohn's disease had significantly higher urinary oxalate and lower magnesium and citrate concentrations. Among all patients magnesium and citrate were significantly lower in those with a positive history of kidney stones. Our results demonstrate that the increased propensity for renal stone formation in patients with Crohn's disease is a result not only of increased urinary oxalate, but also of decreased urinary magnesium and citrate concentrations.

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Section: Discussionmentioning

confidence: 99%

Urinary factors of kidney stone formation in patients with Crohn's disease

et al. 1988

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“…The calcium/magnesium quotient has frequently been used in the biochemical evaluation of stone formers [12][13][14][15] but, as is evident from the results in figures 7 and 8, this quotient is not an appropriate estimate of the risk of developing supersaturated urine. The usefulness of the calcium/magnesium quotient has also been questioned by others [16].…”

Section: Discussionmentioning

confidence: 99%

Different Estimates of the Risk of Calcium Oxalate Crystallization in Urine

Tiselius¹

1983

Eur Urol

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“…21 of our patients (group II) showed relative hypomagnesuria [3,5]. The slope of the correlation in the group was 0.325 for HA and 0.332 for HR -statistically not different from that of their normomagnesuric conterpart.…”

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confidence: 53%

Urinary Magnesium in Response to an Oral Calcium Load

Labeeuw

Pozet

Zech

et al. 1986

Nephron

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Dear Sir,Martinez et al. [4], in their paper on magnesium excre tion in idiopathic hypercalciuria (HC), reported a paral lelism between calcium and magnesium excretion under the conditions studied, including calcium load (CL). However, it is unclear whether the correlation was ob tained independently in each group of HC or only when the 3 populations were studied together. Furthermore, only the regression coefficients were given, not allowing for a comparison of the effect of CL on the magnesiumcalcium relationship. Colussi et al. [1] found that after a CL, the increases in magnesium and calcium excretion were correlated in hyperabsorptive, but not in renal hy percalciuria. We wish to report briefly on our own results.26 hyperabsorptive (HA) and 22 renal (HR) hypercalciuric stone formers and II age-matched controls were studied. All were males to obviate hormonal influences, and they had normal GFR. Urine was collected on 2-hour periods, 2 periods before and 2 periods after a 635-mg oral calcium load. On the basis of the previously pub lished correlation in fasting controls [3], HC were further divided in group I(n = 27; 17 HA and 10 HR) where fasting M g/Cr was normal, and group II (n = 21; 9 HA and 12 HR) where fasting M g/C r was too low for the value of C a/C r (relative hypomagnesuria [4]).In group I, the correlation between M g/Cr and C a/C r (fasting and after CL) is depicted in figure 1. The correla tion was similar in HA (y = 0.064+ 0.409 x ; r = 0.82 left) and in HR (y = 0.035 + 0.411 x ; r = 0.67, right), and not different from that in controls (y = 0.093 +0.365 x ; r= 0.84). We agree with the comments by Martinez et al. [4] that changes in calcium and magnesium excretion after CL depend on parallel changes in the reabsorption of the 2 ions. However, the calcium concentration in the extra cellular fluid is probably more important than the intra tubular calcium, since calcium is known to modulate calcium and magnesium absorption by action on the contraluminal membrane [6,7] in the ascending limb, even in the absence of PTH. Furthermore, changes inCorrelation between urinary M g/Cr and C a/C r ratios, a Hy perabsorptive hypercalciuria (y = 0.064 +0.409 x ; r = 0.82). b Renal hypercalciuria (y = 0.035 + 0.411 x ; r = 0.67).

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Magnesium/Calcium Ratio in Urine of Patients With Renal Stones

Cited by 42 publications

References 9 publications

Urinary factors of kidney stone formation in patients with Crohn's disease

Urinary factors of kidney stone formation in patients with Crohn's disease

Different Estimates of the Risk of Calcium Oxalate Crystallization in Urine

Urinary Magnesium in Response to an Oral Calcium Load

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