Magnesium concentration in plasma, leukocytes and urine of children with intermittent asthma

Mirčetić, Renata Novak; Dodig, Slavica; Raos, Miljenko; Petres, Blanka; Čepelak, Ivana

doi:10.1016/s0009-8981(01)00622-2

Cited by 13 publications

(5 citation statements)

References 29 publications

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“…One of the first events in the release of chemical mediators from basophils and mast cells is a rise in cellular calcium concentration (Yamamoto et al, 1999). Mircetic et al (2001) have reported an increase of total plasma Mg concentration on the first day of asthma attack in children. This increase remains at the same level during 5 days after salbutamol treatment.…”

Section: Asthmamentioning

confidence: 98%

Possible roles of magnesium on the immune system

et al. 2003

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During the last few years, magnesium (Mg) has been subject of research due to its functionality in the organism. It is one of the most important micronutrients, and therefore its role in biological systems has been extensively investigated. Particularly, Mg has a strong relation with the immune system, in both nonspecific and specific immune response, also known as innate and acquired immune response. The aim of this paper is to review the state of the art about the interactions between Mg and the immune system. We discuss the link between dietary Mg and inflammation, apoptosis and alterations in number and function of innate immune cell populations, described in animal models. Furthermore, the immune system can be compromised in human populations under certain circumstances, including athletes and elderly people. The importance of a balanced Mg homeostasis and its interaction with the immune system in these groups has also been reviewed. Although emerging data support the relevant role of Mg in the immune response, further research is needed; and special efforts should be made to establish the most adequate dose in nutritional supplements to reach beneficial effects on health.

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Section: Asthmamentioning

confidence: 98%

Possible roles of magnesium on the immune system

et al. 2003

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“…In a recent study conducted in 30 children with acute asthma attack, plasma Mg levels were normal but erythrocyte magnesium concentration was low, and it was demonstrated that erythrocyte Mg concentration significantly increased after treatment of the acute attack and there was a negative correlation between erythrocyte Mg concentration and the severity of the attack (36). In 26 children aged between 3 and 14 years, who were being followed up for intermittent asthma, an increase was observed in plasma and leukocyte Mg concentrations during acute attack after 5-days treatment (37).…”

Section: Eurasianmentioning

confidence: 99%

Serum Magnesium Concentration in Children with Asthma

Hatipoğlu¹,

Hatipoğlu²,

Türel³

et al. 2014

Eurasian J Pulmonol

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Objective: Asthma is the most common chronic disease of childhood, and magnesium is one of the most frequently found minerals in human body and it is used in the treatment of asthma. Although there are studies on magnesium levels in adult patients with asthma, there is yet no data on the levels of magnesium in children. The present study compared the levels of serum magnesium between the children with asthma and healthy children. Methods:Children aged between 5 and 17 years with mild-moderate persistent asthma, who were admitted to our hospital between January 2009 and August 2010, were included in the study. Serum magnesium levels were measured in 50 patients with acute asthma attack, in 50 patients receiving treatment for stable asthma, and in 50 children admitted to the hospital for any reason and matched with asthma patients except for the diagnosis of asthma. The test was performed by photometric method using Roche-Hitachi Modular P biochemistry analyzer. The normal range of serum Mg was considered to be 1.59-to-2.10 mg/dL and p<0.05 was considered statistically significant. Results:All three groups were similar in terms of mean age and gender distribution. Although mean serum magnesium levels were within the normal range in healthy children and in children treated for stable asthma (1.89±0.32 and 1.93±0.34 mg/dL respectively), it was 1.62±0.26 mg/dL in children having an asthma attack, which was within the normal range but close to the lower limit (p<0.001). Conclusion:Although its efficacy has not been definitely proven, magnesium is used either via intravenous route or as inhaler in acute asthma attack. Knowledge about the changes in body magnesium levels of asthma patients would be a guide for revealing the role of magnesium in the treatment of asthma. As was shown in the present study, magnesium levels tend to decrease in the body during acute attack.

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“…Observational studies suggest associations between several micronutrients and childhood asthma (1), including magnesium (2–9), vitamin D (2, 10–16), selenium (2, 4, 17–22), and zinc (2, 4, 18, 20, 23–25). Only a part of them used objective exposure as well as outcome variables like serum nutrient concentrations, allergic sensitization, and bronchial hyperresponsiveness (BHR) (11, 12, 14, 16, 17, 19).…”

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confidence: 99%