Magnesium deficiency in liver cirrhosis: a retrospective study

Xia, Peng; Xiang, Rengyun; Li, Xuefeng; Tian, Hua; Li, Cuiqin; Peng, Zhe; Xiang, Mingjun

doi:10.1080/00365521.2021.1888154

Cited by 4 publications

(3 citation statements)

References 25 publications

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“…In another study by Göksu and Ozsoylu, magnesium was decreased among children with liver cirrhosis [21]. Other studies had similar findings in terms of magnesium deficiency in liver cirrhosis [22]. Among Iranian healthy children, the prevalence of hypomagnesemia was 5.9% [23].…”

Section: Discussionmentioning

confidence: 69%

Evaluation of micronutrients among pediatric liver cirrhosis in Shiraz, Iran

Dehghani

Amirhakimi

Baligh

et al. 2022

Egypt Liver Journal

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Background Cirrhosis is the final result of most types of liver disease. Zinc, magnesium, and vitamin D have a significantly vital role in the immunologic and physiologic mechanisms in the body. The current study aimed to measure magnesium, zinc, and vitamin D level among children with liver cirrhosis. Results One hundred cases were included in the current study. Vitamin D deficiency was found in 53% of the cases. Zinc deficiency was present in 23% of the cases. The magnesium level was more than the normal level among 99% of the cases. There is a significant inverse correlation between zinc level and PELD score (Pearson correlation = − 0.314, P = 0.007). Conclusion Zinc deficiency and vitamin D deficiency were seen in children with liver cirrhosis. Serum magnesium level in children with liver cirrhosis was higher than standard. A significant correlation was seen between zinc level and PELD score.

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Section: Discussionmentioning

confidence: 69%

Evaluation of micronutrients among pediatric liver cirrhosis in Shiraz, Iran

Dehghani

Amirhakimi

Baligh

et al. 2022

Egypt Liver Journal

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“…To support the hypothesis that Mg depletion may be implicated in the pathogenesis and progression of chronic liver disease, it would also be necessary to demonstrate that tissue Mg content is low in these patients and progressively decreases with increasing the disease severity. As for the studies performed on humans, most of them [35][36][37][38][39][40], although not all [41,42], found lower blood concentrations of Mg in cirrhotic patients than in healthy controls. Similarly, most [38,40,43,44] studies, but not all [35,37,42], have found a progressive reduction in magnesemia that correlated with the worsening of cirrhosis.…”

Section: Introductionmentioning

confidence: 99%

“…As for the studies performed on humans, most of them [35][36][37][38][39][40], although not all [41,42], found lower blood concentrations of Mg in cirrhotic patients than in healthy controls. Similarly, most [38,40,43,44] studies, but not all [35,37,42], have found a progressive reduction in magnesemia that correlated with the worsening of cirrhosis. In a study using the Mg intravenous loading test, a body depletion of Mg was clearly demonstrated in advanced cirrhosis compared to healthy controls [36].…”

Section: Introductionmentioning

confidence: 99%

Severity of Hepatocyte Damage and Prognosis in Cirrhotic Patients Correlate with Hepatocyte Magnesium Depletion

et al. 2023

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We aimed to evaluate the magnesium content in human cirrhotic liver and its correlation with serum AST levels, expression of hepatocellular injury, and MELDNa prognostic score. In liver biopsies obtained at liver transplantation, we measured the magnesium content in liver tissue in 27 cirrhotic patients (CIRs) and 16 deceased donors with healthy liver (CTRLs) by atomic absorption spectrometry and within hepatocytes of 15 CIRs using synchrotron-based X-ray fluorescence microscopy. In 31 CIRs and 10 CTRLs, we evaluated the immunohistochemical expression in hepatocytes of the transient receptor potential melastatin 7 (TRPM7), a magnesium influx chanzyme also involved in inflammation. CIRs showed a lower hepatic magnesium content (117.2 (IQR 110.5–132.9) vs. 162.8 (IQR 155.9–169.8) μg/g; p < 0.001) and a higher percentage of TRPM7 positive hepatocytes (53.0 (IQR 36.8–62.0) vs. 20.7 (10.7–32.8)%; p < 0.001) than CTRLs. In CIRs, MELDNa and serum AST at transplant correlated: (a) inversely with the magnesium content both in liver tissue and hepatocytes; and (b) directly with the percentage of hepatocytes stained intensely for TRPM7. The latter also directly correlated with the worsening of MELDNa at transplant compared to waitlisting. Magnesium depletion and overexpression of its influx chanzyme TRPM7 in hepatocytes are associated with severity of hepatocyte injury and prognosis in cirrhosis. These data represent the pathophysiological basis for a possible beneficial effect of magnesium supplementation in cirrhotic patients.

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