Magnesium disorders and cardiovascular diseases

Purvis, John R.; Movahed, Assad

doi:10.1002/clc.4960150804

Cited by 41 publications

(23 citation statements)

References 188 publications

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“…Both animal and human studies indicate a statistical relationship between a reduced dietary intake of magnesium and cardiovascular disease [1–6]. It is known that the responsiveness of vascular smooth muscle to contractile stimuli in vitro is increased as extracellular ionized Mg 2+ ([Mg 2+ ] o ) is lowered.…”

Section: Introductionmentioning

confidence: 99%

Mg²⁺ modulates membrane sphingolipid and lipid second messenger levels in vascular smooth muscle cells

et al. 1998

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Section: Introductionmentioning

confidence: 99%

Mg²⁺ modulates membrane sphingolipid and lipid second messenger levels in vascular smooth muscle cells

et al. 1998

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“…1 The importance of magnesium has further been emphasized by autopsy studies demonstrating more coronary atherosclerosis and evidence of myocardial infarction in men from soft water areas 2 as well as low magnesium concentrations in cardiac tissue in patients who died from sudden cardiac death. 3 Also supporting the concept is the fact that experimentally induced magnesium deficiency changes the blood lipid composition in a more atherogenic direction.…”

mentioning

confidence: 99%

Oral Magnesium Supplementation Induces Favorable Antiatherogenic Changes in ApoE-Deficient Mice

Ravn

Korsholm

Falk

2001

ATVB

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Abstract-Epidemiological studies indicate that dietary magnesium influences atherogenesis. Magnesium inhibits plaque formation in animals receiving a high cholesterol diet, whereas the effect of magnesium in animals on low-fat diet has not been explored. Magnesium sulfate was given in the drinking water (50 mg/mL) to 7-week-old apolipoprotein E-deficient (apoE Ϫ/Ϫ ) mice (nϭ30). Control animals (nϭ30) received tap water. At the age of 19 weeks, the extent of atherosclerosis and the density of macrophages were measured in the aortic root, and blood lipids were analyzed. The median plaque area was significantly smaller in magnesium-treated female apoE Ϫ/Ϫ mice and reached only 66% of control females (PϽ0.02). Plaque area was also less extensive in magnesium-treated male mice, although not statistically significant. Macrophage density was similar in both groups. Magnesium significantly reduced cholesterol (PϽ0.05) and triglyceride (PϽ0.01) levels, whereas high density lipoprotein cholesterol remained stable. No significant differences in body and heart weight were seen between treatment groups for either sex. In conclusion, in apoE Ϫ/Ϫ mice receiving a low-fat diet, magnesium supplementation significantly inhibited atherogenesis in females but not males. Plaque composition remained unchanged in terms of macrophage density. This was obtained in association with significantly reduced levels of cholesterol and triglycerides.

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“…This may precipitate an acute coronary event in a susceptible heart that is already damaged by long term alcohol use. Other theories suggest that magnesium deficiency and autonomic neuropathy (observed to occur with chronic alcoholism) derail the regulation of coronary vessels at a time of adrenergic crises which can precipitate an obstruction to flow [6,7]. …”

Section: Discussionmentioning

confidence: 99%

Acute coronary ischemia during alcohol withdrawal: a case report

et al. 2011

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IntroductionThe potential of alcohol withdrawal to cause acute coronary events is an area that needs the urgent attention of clinicians and researchers.Case presentationWe report the case of a 52-year-old heavy-alcohol-using Sri Lankan man who developed electocardiogram changes suggestive of an acute coronary event during alcohol withdrawal. Despite the patient being asymptomatic, subsequent echocardiogram showed evidence of ischemic myocardial dysfunction. We review the literature on precipitation of myocardial ischemia during alcohol withdrawal and propose possible mechanisms.ConclusionsAlcohol withdrawal is a commonly observed phenomenon in hospitals. However, the number of cases reported in the literature of acute coronary events occurring during withdrawal is few. Many cases of acute ischemia or sudden cardiac deaths may be attributed to other well known complications of delirium tremens. This is an area needing the urgent attention of clinicians and epidemiologists.

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Magnesium disorders and cardiovascular diseases

Abstract: Summary:The evidence linking magnesium disorders with the pathogenesis and treatment of various cardiovascular diseases will be reviewed.

Cited by 41 publications

References 188 publications

Mg²⁺ modulates membrane sphingolipid and lipid second messenger levels in vascular smooth muscle cells

Mg²⁺ modulates membrane sphingolipid and lipid second messenger levels in vascular smooth muscle cells

Oral Magnesium Supplementation Induces Favorable Antiatherogenic Changes in ApoE-Deficient Mice

Acute coronary ischemia during alcohol withdrawal: a case report

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Magnesium disorders and cardiovascular diseases

Abstract: Summary:The evidence linking magnesium disorders with the pathogenesis and treatment of various cardiovascular diseases will be reviewed.

Cited by 41 publications

References 188 publications

Mg2+ modulates membrane sphingolipid and lipid second messenger levels in vascular smooth muscle cells

Mg2+ modulates membrane sphingolipid and lipid second messenger levels in vascular smooth muscle cells

Oral Magnesium Supplementation Induces Favorable Antiatherogenic Changes in ApoE-Deficient Mice

Acute coronary ischemia during alcohol withdrawal: a case report

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Mg²⁺ modulates membrane sphingolipid and lipid second messenger levels in vascular smooth muscle cells

Mg²⁺ modulates membrane sphingolipid and lipid second messenger levels in vascular smooth muscle cells