Magnesium excretion and hypomagnesemia in pediatric renal transplant recipients

Gökçeoğlu, Arife Uslu; Çomak, Elif; Doğan, Çağla Serpil; Koyun, Mustafa; Akbaş, Halide; Akman, Sema

doi:10.3109/0886022x.2014.917561

Cited by 9 publications

(6 citation statements)

References 14 publications

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“…In hypomagnesemic patients with normal renal function, fractional magnesium excretion is a useful marker for the diagnostic approach to hypomagnesemia versus 24-hour urinary magnesium excretion. 23 In our study, 24-hour urinary magnesium excretion was within reference ranges in 64.8% of patients, but fractional magnesium excretion was higher than the normal limits. It has been reported that tacrolimus level was the best predictor of fractional magnesium excretion.…”

Section: Discussionsupporting

confidence: 46%

“…In adult renal transplant recipients, the prevalence of hypomagnesemia was found to range from 10.2% to 43%. 22 Uslu Gökceoğlu and associates 23 found that the rate of hypomagnesemia in pediatric renal transplant recipients (mean age of 13.6±3.7 y) was 41% and the rate of hypermagnesuria was 65%. In our study, we found that the rate of hypomagnesemia was high in pediatric heart transplant patients versus values reported in adult renal transplant recipients, which is consistent with other pediatric studies.…”

Section: Discussionmentioning

confidence: 99%

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Erdoğan

Gürsu²,

Varan³

et al. 2018

Exp Clin Transplant

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Section: Discussionsupporting

confidence: 46%

Section: Discussionmentioning

confidence: 99%

Untitled

Erdoğan

Gürsu²,

Varan³

et al. 2018

Exp Clin Transplant

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“…Whilst hypomagnesemia is prevalent in children following renal transplantation [11], its association with NODAT has not previously been examined.…”

Section: Introductionmentioning

confidence: 99%

Hypomagnesemia and increased risk of new-onset diabetes mellitus after transplantation in pediatric renal transplant recipients

et al. 2016

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BackgroundNew-onset diabetes after transplantation (NODAT) is a significant co-morbidity following kidney transplantation. Lower post-transplant serum magnesium levels have been found to be an independent risk factor for NODAT in adult kidney transplant recipients.MethodsWe undertook a retrospective analysis of risk factors for NODAT in pediatric renal transplant recipients at our institution with the aim of determining if hypomagnesemia confers a significant risk of developing NODAT in this patient population.ResultsA total of 173 children with a median age at transplantation of 7.0 (range 1.3–17.5) years were included. Hypomagnesemia was found to be a significant independent risk factor for NODAT (p = 0.01). High trough tacrolimus levels were also independently associated with NODAT (p < 0.001). There was no significant association between NODAT and body mass index at the time of transplantation, monthly cumulative steroid dose or post-transplant cytomegalovirus viremia (p = 0.9, 0.6 and 0.7, respectively).ConclusionsThis study identifies hypomagnesemia as a significant independent risk factor for the development of NODAT in pediatric renal transplant recipients. Given the clear association between hypomagnesemia and NODAT in both adults and children following renal transplantation, further studies are merited to clarify the etiology of this association and to examine the effect of magnesium supplementation on NODAT.

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“…In the present study, the renal function of the children with CKD (the CKD group) was also determined with chromium-51 EDTA analysis (data not shown), which showed a significant relation with the FE Mg 2+ . Also in pediatric patients after kidney transplantation, FE Mg 2+ was negatively correlated with the renal function [ 45 , 46 ]. In adult patients, the renal function did not predict FE Mg 2+ [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Longitudinal Study of the Role of Epidermal Growth Factor on the Fractional Excretion of Magnesium in Children: Effect of Calcineurin Inhibitors

et al. 2018

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Background: It was shown in animal models and adults that the epidermal growth factor (EGF) is involved in the pathophysiology of calcineurin inhibitor (CNI) induced renal magnesium loss. In children, however, the exact mechanism remains unclear, which was set as the purpose of the present study. Methods: Children with nephrotic syndrome and renal transplant children treated with CNI (n = 50) and non-CNI treated children (n = 46) were included in this study. Urine and serum samples were collected at three time points to determine magnesium, creatinine, and EGF. The magnesium intake was calculated from a food frequency questionnaire. Results: Serum Mg2+ and urinary EGF/creatinine were significantly lower in the CNI treated children, with significantly more CNI-treated children developing hypomagnesaemia. In the latter patients, the fractional excretion of magnesium (FE Mg2+) was significantly higher. Urinary EGF, age, renal function, and serum magnesium were independent predictors of the FE Mg2+. Only 29% of the children reached the recommended daily intake of magnesium. The magnesium intake did not differ between hypomagnesemic and normomagnesemic patients and was not a predictor of the FE Mg2+. Conclusions: In CNI-treated children who developed hypomagnesemia, the FE Mg2+ was increased. The urinary EGF concentration, age, and renal function are independent predictors of the FE Mg2+.

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Magnesium excretion and hypomagnesemia in pediatric renal transplant recipients

Abstract: Patients with higher tacrolimus trough blood levels, lower glomerular filtration rate and at early posttransplant period had risk of hypomagnesemia.

Cited by 9 publications

References 14 publications

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Hypomagnesemia and increased risk of new-onset diabetes mellitus after transplantation in pediatric renal transplant recipients

Longitudinal Study of the Role of Epidermal Growth Factor on the Fractional Excretion of Magnesium in Children: Effect of Calcineurin Inhibitors

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