Magnesium Homeostasis and Clinical Disorders of Magnesium Deficiency

Whang, Robert; Hampton, Edward M.; Whang, David D.

doi:10.1177/106002809402800213

Cited by 110 publications

(90 citation statements)

References 42 publications

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“…21,22 Both population-based and tertiary care center studies have shown that older black persons have nearly double the incidence rate of epilepsy compared to whites, a finding consistent with their estimates. Stroke is the most common known cause of epilepsy in the older adult population and blacks have a 2-fold increased risk of stroke compared with whites living in the same community.…”

Section: Resultssupporting

confidence: 77%

“…We do not believe that this is a result of reverse causality, in which epilepsy leads to lower educational attainment, because participants' education was completed long before enrolment in CHS or age 65. 22 This particular finding raises the question of socioeconomic status serving as an independent risk factor or a proxy for some other risk factor for epilepsy in older adults, not confounded by other risk factors such as cerebrovascular disease.…”

Section: Resultsmentioning

confidence: 99%

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Profile and Short-Term Outcome in Adult Patients With New-Onset Seizures

Gopi¹,

Chowdary²

2018

jebmh

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BACKGROUNDThe annual incidence is 85 per 1,00,000 for people aged 65-69 years and 135 per 1,00,000 for those aged over 80 years. Epilepsy in older patients poses several additional problems for the provision of services compared with the rest of the population as diagnostic difficulties and polypharmacy. The aim of the study is to-1. Know the various causes of seizures, clinical profile and correlation between neurological imaging and VEEG characteristics. 2. Know the differences between the aetiologies of seizures in young age and elderly >65 years.

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Section: Resultssupporting

confidence: 77%

Section: Resultsmentioning

confidence: 99%

Profile and Short-Term Outcome in Adult Patients With New-Onset Seizures

Gopi¹,

Chowdary²

2018

jebmh

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“…Second, magnesium level is not examined “routinely” in blood test. [18] Third, patients may be hypomagnesemic, even with a normal serum magnesium level. And finally, magnesium deficiencies are generally masked by other electrolyte deficiencies.…”

Section: Discussionmentioning

confidence: 99%

General characteristics of patients with electrolyte imbalance admitted to emergency department

Balcı¹,

Köksal²,

Köse³

et al. 2013

World Journal of Emergency Medicine

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BACKGROUND:Fluid and electrolyte balance is a key concept to understand for maintaining homeostasis, and for a successful treatment of many metabolic disorders. There are various regulating mechanisms for the equilibrium of electrolytes in organisms. Disorders of these mechanisms result in electrolyte imbalances that may be life-threatening clinical conditions. In this study we defined the electrolyte imbalance characteristics of patients admitted to our emergency department.METHODS:This study was conducted in the Emergency Department (ED) of Uludag University Faculty of Medicine, and included 996 patients over 18 years of age. All patients had electrolyte imbalance, with various etiologies other than traumatic origin. Demographic and clinical parameters were collected after obtaining informed consent from the patients. The ethical committee of the university approved this study.RESULTS:The mean age of the patients was 59.28±16.79, and 55% of the patients were male. The common symptoms of the patients were dyspnea (14.7%), fever (13.7%), and systemic deterioration (11.9%); but the most and least frequent electrolyte imbalances were hyponatremia and hypermagnesemia, respectively. Most frequent findings in physical examination were confusion (14%), edema (10%) and rales (9%); and most frequent pathological findings in ECG were tachycardia in 24%, and atrial fibrillation in 7% of the patients. Most frequent comorbidity was malignancy (39%). Most frequent diagnoses in the patients were sepsis (11%), pneumonia (9%), and acute renal failure (7%).CONCLUSIONS:Electrolyte imbalances are of particular importance in the treatment of ED patients. Therefore, ED physicians must be acknowledged of their fluid-electrolyte balance dynamics and general characteristics.

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“…The homeostasis of Mg depends on supplementation, accumulation and extraction with diuresis, stool and perspiration. Daily demand of Mg increases with age and ranges between 300-400 mg per day in adults [2]. Physiological plasma Mg concentration ranges from 0.8-1.2 mmol/L, and even the smallest changes in its plasma level reflects in its intracellular level, leading to cellular dysfunctions [1,3].…”

Section: Introductionmentioning

confidence: 99%

“…Its deficiency leads to many life-threatening disorders, particularly of the heart and central nervous system [1,2]. The homeostasis of Mg depends on supplementation, accumulation and extraction with diuresis, stool and perspiration.…”

Section: Introductionmentioning

confidence: 99%

Plasma magnesium concentration in patients undergoing coronary artery bypass grafting

Kotlińska-Hasiec¹,

Makara‐Studzińska²,

Czajkowski³

et al. 2017

Ann Agric Environ Med.

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Plasma magnesium concentration in patients undergoing coronary artery bypass grafting Kotlinska-Hasiec E, Makara-Studzinska M, Czajkowski M, Rzecki Z, Olszewski K, Stadnik A, Pilat J, Rybojad B, Dabrowski W. Ann Agric Environ Med. 2017; 24(2): 181-184. doi: 10.5604/12321966.1232762 Abstract Introduction. Magnesium (Mg) plays a crucial role in cell physiology and its deficiency may cause many disorders which often require intensive treatment. The aim of this study was to analyse some factors affecting preoperative plasma Mg concentration in patients undergoing coronary artery bypass grafting (CABG). Materials and method. Adult patients scheduled for elective CABG with cardio-pulmonary bypass (CPB) under general anaesthesia were studied. Plasma Mg concentration was analysed before surgery in accordance with age, domicile, profession, tobacco smoking and preoperative Mg supplementation. Blood samples were obtained from the radial artery just before the administration of anaesthesia. Results. 150 patients were studied. Mean preoperative plasma Mg concentration was 0.93 ± 0.17 mmol/L; mean concentration in patients -1.02 ± 0.16; preoperative Mg supplementation was significantly higher than in patients without such supplementation. Moreover, intellectual workers supplemented Mg more frequently and had higher plasma Mg concentration than physical workers. Plasma Mg concentration decreases in elderly patients. Patients living in cities, on average, had the highest plasma Mg concentration. Smokers had significantly lower plasma Mg concentration than non-smokers. Conclusions. 1. Preoperative magnesium supplementation increases its plasma concentration. 2. Intellectual workers frequently supplement magnesium. 3. Smoking cigarettes decreases plasma magnesium concentration.

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Magnesium Homeostasis and Clinical Disorders of Magnesium Deficiency

Cited by 110 publications

References 42 publications

Profile and Short-Term Outcome in Adult Patients With New-Onset Seizures

Profile and Short-Term Outcome in Adult Patients With New-Onset Seizures

General characteristics of patients with electrolyte imbalance admitted to emergency department

Plasma magnesium concentration in patients undergoing coronary artery bypass grafting

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