Magnesium in critical illness: metabolism, assessment, and treatment

Noronha, Luis J.; Matuschak, George M.

doi:10.1007/s00134-002-1281-y

Cited by 130 publications

(83 citation statements)

References 112 publications

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“…On the basis of the reduction in mouse maternal plasma Mg concentrations with respect to previously published guidelines (22,23), this model appears to produce moderate Mg deficiency. Maternal plasma Mg concentrations decline over the course of pregnancy (24).…”

Section: Discussionmentioning

confidence: 78%

Maternal Magnesium Deficiency in Mice Leads to Maternal Metabolic Dysfunction and Altered Lipid Metabolism with Fetal Growth Restriction

Gupta

Solanki

Chatterjee

et al. 2014

Mol Med

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Section: Discussionmentioning

confidence: 78%

Maternal Magnesium Deficiency in Mice Leads to Maternal Metabolic Dysfunction and Altered Lipid Metabolism with Fetal Growth Restriction

Gupta

Solanki

Chatterjee

et al. 2014

Mol Med

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“…Thus, the application of 19 F NMR with appropriately designed reporter molecules gives insight into cytosolic [Ca 2þ ]. Magnesium ions are also involved in biological processes and occur in cells at millimolar concentrations [315]. Magnesium can be estimated based on the chemical shift difference of the resonances of adenosine triphosphate (ATP) using 31 P NMR [316][317][318], though 31 P NMR has intrinsically low signal-to-noise, exacerbated under many pathophysiological conditions, such as ischemia.…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 99%

VatuximabTM: Optimizing Therapeutic Strategies for Prostate Cancer Based on Dynamic MR Tumor Oximetry

Mason¹

2007

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“…Next to calcium, magnesium is the main mineral component which is necessary for the proper formation of the skeletal structure (FORMANOWICZ, FORMANOWICZ 2004, £ONIEWSKI 2003. On a cellular level, magnesium acts as an activator of many enzymes (NORONHA, MATUSCHAK 2002, PASTERNAK 2000, SARIS 2000, WOLF, CITTADINI 2003.…”

Section: Introductionmentioning

confidence: 99%

“…The proper magnesium concentration in the plasma ranges from 0.7 to 1.2 mmol dm -3 (NORONHA, MATUSCHAK 2002), and owing to magnesium release from tissues, mainly bones, it is possible to keep it at this level even during high Mg deficiency. Thus, changes in magnesium concentration in the plasma do not inform us about its reserve in tissues, but can indicate magnesium metabolism (MARCINKOWSKA-SUCHOWIERSKA 1991, NORONHA, OGOÑSKI et al 1997.…”

Section: Introductionmentioning

confidence: 99%

Plasma calcium and magnesium concentrations in patients with fractures of long bones treated surgically

Bacher¹,

Sztanke²,

Sztanke³

et al. 2012

J. Elem.

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Bone fractures, especially when treated surgically, are connected with changes in the homeostasis of the elements of which bone compounds consist, as well as the ones which participate in controlling processes. Such changes influence both the fracture itself and the operative procedure. For successful treatment of broken bones, it can be crucial to bring the homeostasis of bioelements back to the normal state.Thus, the aim of this work has been to determine magnesium and calcium concentrations in plasma from patients with fractures of long bones, and to analyze changes in the examined elements depending on the time after the operative procedure, injury and patient's age.The research was conducted on the blood of patients: 1) with long bone fractures treated surgically, 2) after a limb amputation because of a fracture or injury, 3) with long bone fractures and with multiorgan injury. With respect to the patients' age, there were 3 groups: 1) patients aged 18-40 years, 2) patients aged 41-60 years, 3) patients older than 60 years. In the postoperative period, the patients were on a strict postoperative diet, receiving only i.v. 0.9% NaCl and 5% glucose solutions.Blood was taken from patients first directly after admittance to hospital and next on the first, third, fifth and seventh day after an operative procedure.Plasma calcium and magnesium concentrations were determined by the method of emission spectrometry with induction plasma (ICP-OES). The results were worked out statistically. The differences p<0.05 were taken into consideration as statistically significant.The research showed that in the blood plasma from patients with long bone fractures treated surgically, there were noticeable decreases of calcium and magnesium concentra-6 tions mainly on the first, third and fifth postoperative day. These changes depended on the extend of an operative procedure, but did not depend on the patients' age. However, with respect to magnesium, its statistically significant decrease was noticed in the group of oldest patients.In the postoperative period, it is especially important to pay attention to calcium and magnesium concentrations, and for patients over 60 years of age magnesium supplementation is necessary. Maintenance of macronutrient homeostasis in an organism can be crucial for the patient's convalescence process.Key words: calcium, magnesium, long bone's fractures, surgical treatment. OSOCZOWE STÊ¯ENIA WAPNIA I MAGNEZU U PACJENTÓW ZE Z£AMANIAMI KOOECI D£UGICH LECZONYCH OPERACYJNIE AbstraktZ³amania kooeci, szczególnie leczone operacyjnie, wi¹¿¹ siê ze zmianami homeostazy pierwiastków wchodz¹cych w sk³ad zwi¹zków buduj¹cych kooeci, a tak¿e bior¹cych udzia³ w procesach regulacyjnych. Wp³ywa na to zarówno samo z³amanie, jak i zabieg operacyjny. Normalizacja zaburzeñ w homeostazie biopierwiastków mo¿e mieae istotne znaczenie dla zrostu kooeci w procesie zdrowienia pacjenta ze z³amaniem.Celem pracy by³o oznaczenie stê¿eñ magnezu i wapnia w osoczu krwi pacjentów hospitalizowanych z powodu z³amañ kooeci d³ugich o...

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Magnesium in critical illness: metabolism, assessment, and treatment

Cited by 130 publications

References 112 publications

Maternal Magnesium Deficiency in Mice Leads to Maternal Metabolic Dysfunction and Altered Lipid Metabolism with Fetal Growth Restriction

Maternal Magnesium Deficiency in Mice Leads to Maternal Metabolic Dysfunction and Altered Lipid Metabolism with Fetal Growth Restriction

VatuximabTM: Optimizing Therapeutic Strategies for Prostate Cancer Based on Dynamic MR Tumor Oximetry

Plasma calcium and magnesium concentrations in patients with fractures of long bones treated surgically

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