Magnesium intake, insulin resistance and markers of endothelial function among women

Bavani, Narges Ghorbani; Saneei, Parvane; Keshteli, Ammar Hassanzadeh; Yazdannik, Ahmadreza; Falahi, Ebrahim; Sadeghi, Omid; Esmaillzadeh, Ahmad

doi:10.1017/s1368980021001063

Cited by 7 publications

(8 citation statements)

References 43 publications

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“…Prior studies have proved that controlling glycaemia is the best approach to prevent subsequent disorders among patients with diabetes [3]. Recently, it has been shown that supplementation with antioxidants, such as vitamin E, may ameliorate endothelial cell dysfunction in patients with diabetes [4,5]. However, it is unclear whether this is mediated through the effect of vitamin E on glycemic indices and insulin resistance or other pathways.…”

Section: Introductionmentioning

confidence: 99%

Effect of vitamin E intake on glycemic control and insulin resistance in diabetic patients: an updated systematic review and meta-analysis of randomized controlled trials

Asbaghi

Nazarian

Yousefi

et al. 2023

Nutr J

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Since a 2014 meta-analysis, several randomized controlled trials (RCTs) evaluating the effect of vitamin E intake on glycemic indices and insulin resistance in adults with diabetes have reached inconsistent conclusions. Therefore, we updated the previous meta-analysis to summarize the current evidence in this regard. Online databases including PubMed, Scopus, ISI Web of Science, and Google Scholar were searched to identify relevant studies published up to September 30, 2021, using relevant keywords. Random-effects models were used to obtain overall mean difference (MD) comparing vitamin E intake with a control group. In total, 38 RCTs with a total sample size of 2171 diabetic patients (1110 in vitamin E groups and 1061 in control groups) were included. Combining the results from 28 RCTs on fasting blood glucose, 32 RCTs on HbA1c, 13 RCTs on fasting insulin, and 9 studies on homeostatic model assessment for insulin resistance (HOMA-IR) showed a summary MD of -3.35 mg/dL (95% CI: -8.10 to 1.40, P = 0.16), -0.21% (95% CI: -0.33 to -0.09, P = 0.001), -1.05 µIU/mL (95% CI: -1.53 to -0.58, P < 0.001), and -0.44 (95% CI: -0.82 to -0.05, P = 0.02), respectively. This indicates a significant lowering effect of vitamin E on HbA1c, fasting insulin and HOMA-IR, while no significant effect on fasting blood glucose in diabetic patients. However, in subgroup analyses, we found that vitamin E intake significantly reduced fasting blood glucose in studies with an intervention duration of < 10 weeks. In conclusion, vitamin E intake has a beneficial role in improving HbA1c and insulin resistance in a population with diabetes. Moreover, short-term interventions with vitamin E have resulted in lower fasting blood glucose in these patients. This meta-analysis was registered in PROSPERO with code CRD42022343118.

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Section: Introductionmentioning

confidence: 99%

Effect of vitamin E intake on glycemic control and insulin resistance in diabetic patients: an updated systematic review and meta-analysis of randomized controlled trials

Asbaghi

Nazarian

Yousefi

et al. 2023

Nutr J

Self Cite

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“…After taking all potential confounders into account, it showed that more dietary Mg intake was associated with lower markers levels, although this difference was not significant in the fully adjusted model except for sICAM-1 levels: more dietary Mg intake was associated with lower sICAM-1 levels (Q 1 : 239 mg/l, Q 2 : 214 mg/l, Q 3 : 196 mg/l and Q 4 : 195 mg/l, P ¼ 0Á29) [22].…”

Section: Magnesiummentioning

confidence: 88%

“…In the past year, only one study was performed trying to identify correlations between vascular function and magnesium intake and it was conducted in a group of women ( n = 345), by assessment of dietary intake of magnesium and quantification of endothelial function markers (adhesion molecules such as E-selectin, Soluble Inter-cellular Adhesion Molecule-1 (sICAM-1) and Vascular cell adhesion molecule 1 (sVCAM-1)) [22].…”

Section: Recent Findingsmentioning

confidence: 99%

Effects of micronutrient and phytochemical supplementation on cardiovascular health in obese and overweight children: a narrative review

Vrech

Ferruzzi

Pietrobelli

2022

Current Opinion in Clinical Nutrition &Amp; Metabolic Care

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Purpose of reviewCardiovascular damage could begin early in life. Our aim was to examine the current state of the art related to micronutrient supplementation on vascular health in obese and overweight children. We considered only the studies performed over the past few years.Recent findingsVitamin D supplementation in the obese pediatric population with vitamin D deficiency could improve the vascular health of these subjects. The evidence is less clear on supplementation with other micronutrients. Zinc supplementation is currently the most supported by the literature.SummaryAs of today, we can only speculate that supplementation with other micronutrients could improve the vascular health of obese and overweight children. Strong limitations are the different instrumental methods used to assess vascular health in obese children and adolescents under micronutrients supplementation. Actually, indirect indicators more reliable to evaluate vascular health seem to be lipid profile and insulin sensitivity. Furthermore, there is a particular lack of studies in this area in recent years, especially in the pediatric population. Additional studies performed in this population should be pursued to clarify significant relationships between micronutrients and vascular health.

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“…For instance, it has been suggested that IR could be affected by several nutrients such as vitamin D, chromium 16 , magnesium 17 , fiber 18 , dietary fats such as polyunsaturated and omega 3 fatty acids 19 , 20 and specific polyphenols such as anthocyanins 21 , resveratrol 22 , and quercetins 23 , 24 . Additionally, endothelial dysfunction could be influenced by nutrients such as magnesium 25 , flavanol 26 , vitamins C and E 27 , and lycopene 28 .…”

Section: Introductionmentioning

confidence: 99%

Nutrient patterns in relation to insulin resistance and endothelial dysfunction in Iranian women

Dehghani,

Hajhashemy,

Keshteli

et al. 2024

Sci Rep

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Prior studies have mainly focused on the association of one specific nutrient with insulin resistance (IR) and endothelial dysfunction and limited studies have assessed the association with different nutrient patterns (NPs). We examined the association between various NPs and IR and endothelial dysfunction among Iranian women. This cross-sectional study was carried out on a sample of 368 female nurses. A 106-items food frequency questionnaire (FFQ) was applied for dietary assessments. Using factor analysis, the relationships between NPs and markers of insulin resistance (HOMA-IR, HOMA-β, and QUICKY), and endothelial dysfunction (E-selectin, sICAM-1, and sVCAM-1) were assessed. Mean age and body mass index of participants were respectively 35.21 years and 24.04 kg/m2. Three major NPs were identified. NP1, named as “dairy, fruits, and vegetables” had high values of potassium, folate, vitamins A and C, magnesium, and beta carotene. No significant association was observed between this NP and insulin resistance or endothelial dysfunction indices. The second NP was full of chromium, selenium, copper, vitamin B6, monounsaturated fatty acid (MUFA), thiamin, vitamin D, and iron. Adherence to NP2 (named “legumes, nuts, and protein foods”) was associated with lower values of insulin (6.8 ± 1.1 versus 8.4 ± 1.1, P = 0.01), homeostasis model assessment-Insulin resistance (HOMA-IR) (1.3 ± 0.2 versus 1.7 ± 0.2, P = 0.02), and vascular adhesion molecule 1 (VCAM-1) (444.2 ± 27.9 versus 475.8 ± 28.4, P = 0.03). However, adherence to the third NP, rich in saturated fatty acid (SFA), cholesterol, sodium, zinc, vitamin E, and B12, described as “animal fat and meat + vitamin E”, was associated with higher amounts of homeostasis model assessment-β (HOMA-β) (531.3 ± 176.2 versus 48.7 ± 179.8, P = 0.03). In conclusion, following the NP2, correlated with higher intakes of chromium, selenium, copper, vitamin B6, MUFA and thiamin was associated with lower values of insulin, HOMA-IR, and sVCAM-1. Adherence to NP3, rich in SFA, cholesterol, vitamin E, vitamin B12, and zinc was associated with higher levels of HOMA-β.

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Magnesium intake, insulin resistance and markers of endothelial function among women

Cited by 7 publications

References 43 publications

Effect of vitamin E intake on glycemic control and insulin resistance in diabetic patients: an updated systematic review and meta-analysis of randomized controlled trials

Effect of vitamin E intake on glycemic control and insulin resistance in diabetic patients: an updated systematic review and meta-analysis of randomized controlled trials

Effects of micronutrient and phytochemical supplementation on cardiovascular health in obese and overweight children: a narrative review

Nutrient patterns in relation to insulin resistance and endothelial dysfunction in Iranian women

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