Magnesium interrelationships in ischemic heart disease: a review

Abstract

Cummings and Clark (4) Cummings (3) Rigo et al. (5) INTERRELATIONSHIPS IN HEART DISEASE 61 a Coronary ligation. b Ringer's solution without Mg. C Two milliequivalents Mg in 5% dextrose. water to the calcium and magnesium intakes of

The Prospect of Serum Magnesium and an Electrolyte Panel as an Adjuvant Cardiac Biomarker in the Management of Acute Myocardial Infarction

“…The theory of Seelig and Heggtveit states that the magnesium deficient status and an altered electrolyte concentration are caused by the reduction of the Na/K ATPase activity, leading to sodium accumulation in the cardiac myocytes. Elevated myocardial sodium levels would result in the reversal of the Na+/k+ exchange and a rise in the intracellular calcium levels [19].This intracellular shift in calcium decreases the ionized calcium levels in the serum. This explains the electrical instability in the hearts of magnesium deficient individuals.…”

Recommendations for the nutritional management of patients with diabetes mellitus

“…Magnesium de®ciency can also lead to increased platelet aggregation (Hwang et al, 1993). It has also been linked epidemiologically with increased risk for diabetic retinopathy (McNair et al, 1978) and ischaemic heart disease (Seelig et al, 1974). Choice of oral hypoglycaemic agents may affect magnesium handling: biguanide usage is linked with hypomagnesaemia, whereas glipizide raises serum magnesium (McBain et al, 1988).…”

Withdrawal of Magnesium Enhances Coronary Arterial Spasms Produced by Vasoactive Agents

“…Experimental and clinical evidence suggest that magnesium (Mg2') deficiency, in animals and man, could be a significant factor in the aetiology of several cardiovascular disease states (Seelig & Heggtveit, 1974;Burch & Giles, 1977;Altura, 1979;Altura 1980;Altura & Altura, 1981). In a recent in vitro strudy, we demonstrated that acute withdrawal of magnesium induces contractile responses in canine coronary arteries (Turlapaty & Altura, 1980).…”