Magnesium levels and outcome after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia

Angenendt, Linus; Hilgefort, Isabel; Mikesch, Jan‐Henrik; Schlüter, B.; Berdel, Wolfgang E.; Lenz, Georg; Stelljes, Matthias; Schliemann, Christoph

doi:10.1007/s00277-020-04382-y

Cited by 5 publications

(3 citation statements)

References 10 publications

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“…Only one article enrolling patients after allo-HSCT studied it till now and found no relevance of cyclosporine A values and magnesium nor OS. 12 Our study has several limitations. First, it was a retrospective, single-center cohort study with a small sample size.…”

Section: Discussionmentioning

confidence: 91%

“…As a consequence, we could not further explore the correlation of cyclosporine A concentration and magnesium levels or OS. Only one article enrolling patients after allo‐HSCT studied it till now and found no relevance of cyclosporine A values and magnesium nor OS 12 …”

Section: Discussionmentioning

confidence: 99%

“…The role of magnesium in the immune system has also been implied in patients with allo‐HSCT 12 . High post‐transplant magnesium levels are independently associated with a lower incidence of relapse, a higher non‐relapse mortality in AML patients after allo‐HSCT.…”

Section: Introductionmentioning

confidence: 99%

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Magnesium enhances the graft‐versus‐tumor effect of donor lymphocytic infusion on hematologic malignancies

Wei

Guo

Lü

et al. 2023

Hematological Oncology

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Donor lymphocyte infusion (DLI) cures relapsed hematologic malignancies after allogeneic hematopoietic stem cell transplantation through the graft‐versus‐tumor (GVT) effect. Although the important role of magnesium in enhancing immunity has been mentioned in studies, limited clinical data have explored how magnesium affects the efficacy of DLI. Besides, although laboratory data demonstrate that magnesium can enhance CD8+ T cells effector function, whether magnesium regulates the tumor killing effect of peripheral blood mononuclear cells (PBMCs) remains to be explored. Here, for the retrospective study, we collected clinical data of relapsed patients receiving DLI and explored the relationship between different serum magnesium levels and patient outcomes. For in vitro studies, we investigated the effect of magnesium on the cytotoxicity of DLI cells which were PBMCs and preliminarily explored the mechanism. Eighty‐one patients were enrolled in this study. It was found that the high post‐DLI magnesium level was significantly associated with a higher incidence of complete remission (CR) or partial remission (CR/PR) and a higher possibility of survival. The magnesium level after DLI was an independent risk factor of overall survival. In vitro studies proved that increased magnesium enhanced the cytotoxic function of PBMCs on hematologic malignancies. Besides, magnesium modulated LFA‐1 headpiece opening. When blocking the integrin‐ligand interaction between LFA‐1 and ICAM‐1, the regulation effect of magnesium on PBMCs was weakened. Therefore, it was possible that magnesium regulated PBMCs effector function by stimulating LFA‐1. These results show that serum magnesium levels affect immunological responses mediated by donor lymphocytes in hematologic malignancies.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Magnesium enhances the graft‐versus‐tumor effect of donor lymphocytic infusion on hematologic malignancies

Wei

Guo

Lü

et al. 2023

Hematological Oncology

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Association of CDSS score and 60-day mortality in Chinese patients with non-APL acute myeloid leukemia: a retrospective cohort study

Zhong¹,

Chen

Xiao

et al. 2023

J Thromb Thrombolysis

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Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy, and is one of the triggers of DIC, the latter is an essential factor in the early death of patients with AML. However, the timely identification of DIC remains a challenge. The Chinese DIC Scoring System (CDSS) is a common consensus widely used in China; but, there are few reports on its application in patients with AML. We undertake this retrospective cohort study to investigate the association between CDSS score and 60-day mortality. CDSS scores were evaluated after admission. The outcome was all-cause 60-day mortality. Multivariate Cox regression analyses were performed to calculate the adjusted hazard ratio (HR) and the corresponding 95% confidence interval (CI). Survival curves were plotted by Kaplan–Meier and log-rank analyses. Subgroup analyses were stratified by relevant effect covariates. A total of 570 consecutive patients with primary AML were included. We found an association between a 39% increase in 60-day mortality and a 1 point increase in CDSS score (HR = 1.39, 95% CI 1.25–1.54), which was associated with a 189% increase in 60-day mortality in CDSS scores ≥ 6 compared with that in the CDSS scores < 6 (HR = 2.89, 95% CI 1.91–4.38). After adjusting for all potential con-founders, a 27% and a 198% increase were observed (HR = 1.27, 95% CI 1.01–1.61; HR = 2.98, 95% CI 1.24–7.19), respectively. There is association between 60-day mortality and CDSS score in patients with AML. These findings may help hematologists in making informed treatment decisions.

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Magnesium sensing via LFA-1 regulates CD8+ T cell effector function

Lötscher

Líndez

Kirchhammer

et al. 2022

Cell

130

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Magnesium levels and outcome after allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia

Cited by 5 publications

References 10 publications

Magnesium enhances the graft‐versus‐tumor effect of donor lymphocytic infusion on hematologic malignancies

Magnesium enhances the graft‐versus‐tumor effect of donor lymphocytic infusion on hematologic malignancies

Association of CDSS score and 60-day mortality in Chinese patients with non-APL acute myeloid leukemia: a retrospective cohort study

Magnesium sensing via LFA-1 regulates CD8+ T cell effector function

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