Magnesium may be an effective therapy for Alzheimer’s disease

Lei, Dao-Yun; Sun, Jun

doi:10.5498/wjp.v12.i9.1261

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…However, although patients suffering from AD have lower magnesium concentrations, their deficiency levels cannot be accurately evaluated. Slutsky et al reported that after longterm supplementation, the Mg 2+ concentration in cerebrospinal fluid increased only by 15% [93]. The blood-brain barrier keeps at bay the daily fluctuations in blood magnesium and their possible impact on the brain tissue.…”

Section: Magnesium (Mg)mentioning

confidence: 99%

Trace Elements in Alzheimer’s Disease and Dementia: The Current State of Knowledge

Tyczyńska,

Gędek,

Brachet

et al. 2024

JCM

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Changes in trace element concentrations are being wildly considered when it comes to neurodegenerative disorders, such as Alzheimer’s disease and Parkinson’s disease. This study aims to present the role that trace elements play in the central nervous system. Moreover, we reviewed the mechanisms involved in their neurotoxicity. Low zinc concentrations, as well as high levels of copper, manganese, and iron, activate the signalling pathways of the inflammatory, oxidative and nitrosative stress response. Neurodegeneration occurs due to the association between metals and proteins, which is then followed by aggregate formation, mitochondrial disorder, and, ultimately, cell death. In Alzheimer’s disease, low Zn levels suppress the neurotoxicity induced by β-amyloid through the selective precipitation of aggregation intermediates. High concentrations of copper, iron and manganese cause the aggregation of intracellular α-synuclein, which results in synaptic dysfunction and axonal transport disruption. Parkinson’s disease is caused by the accumulation of Fe in the midbrain dopaminergic nucleus, and the pathogenesis of multiple sclerosis derives from Zn deficiency, leading to an imbalance between T cell functions. Aluminium disturbs the homeostasis of other metals through a rise in the production of oxygen reactive forms, which then leads to cellular death. Selenium, in association with iron, plays a distinct role in the process of ferroptosis. Outlining the influence that metals have on oxidoreduction processes is crucial to recognising the pathophysiology of neurodegenerative diseases and may provide possible new methods for both their avoidance and therapy.

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Section: Magnesium (Mg)mentioning

confidence: 99%

Trace Elements in Alzheimer’s Disease and Dementia: The Current State of Knowledge

Tyczyńska,

Gędek,

Brachet

et al. 2024

JCM

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“…The synapses in hippocampus are quite sensitive to the fluctuations in magnesium concentration. Therefor an increase in half of magnesium concentration wills double the density of synapse [14]. Hypomagnesaemia is a potential risk factor for dementia, hypertension, cerebrovascular accidents, and thrombotic plaques [15].…”

Section: Introductionmentioning

confidence: 99%

Magnesium and Memory: Unraveling the Physiological Tapestry of Alzheimer's Disease

Uddin,

Waheed,

Chohan

et al. 2024

JSRR

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Background: Alzheimer disease is the leading cause of Dementia throughout the world. There are multiple researches are undergoing globally to understand the etiology of this disabling disease. Magnesium is another suspicious factor that might produce this disease. Objectives: The study was aimed to evaluate possible association between serum magnesium and Alzheimer disease. Methodology: This case control study was conducted in the emergency Department in collaboration of Medical OPD of Liquate University Hospital Hyderabad from January 2023 to December 2023. 300 participants were divided into control, 200 participants and 100 in the test group. Serum Magnesium was evaluated into both control and test group. Graph Pad Prism 9 was used to detect P value. Significance of variable was considered below 0.05. Results: Those who were suffering from Alzheimer disease shows more Hypomagnesaemia (p-value= 0.001) than normal patients. The low serum Magnesium level was found 3.1 times greater (Odds ratio= 5.5, likelihood ratio= 1.9) in Alzheimer patients Conclusion: there is a specific association between Hypomagnesaemia and Alzheimer disease.

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Modifiable chemical risk factors for amyloid-β and Tau protein in Alzheimer’s disease

Chinnathambi,

Malik,

Kumarappan

et al. 2024

Advances in Protein Chemistry and Structural Biology

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Magnesium may be an effective therapy for Alzheimer’s disease

Cited by 3 publications

References 8 publications

Trace Elements in Alzheimer’s Disease and Dementia: The Current State of Knowledge

Trace Elements in Alzheimer’s Disease and Dementia: The Current State of Knowledge

Magnesium and Memory: Unraveling the Physiological Tapestry of Alzheimer's Disease

Modifiable chemical risk factors for amyloid-β and Tau protein in Alzheimer’s disease

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