Magnesium-promoted nickel-catalysed chlorination of aryl halides and triflates under mild conditions

Zhang, Tian-Yu; Bilal, Muhammad; Wang, Tian-Zhang; Zhang, Chao-Peng; Liang, Yu-Feng

doi:10.1039/d4cc04383a

Chem. Commun.

2024

DOI: 10.1039/d4cc04383a

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Magnesium-promoted nickel-catalysed chlorination of aryl halides and triflates under mild conditions

Tian-Yu Zhang,

Muhammad Bilal,

Tian-Zhang Wang

et al.

Abstract: In this study, we present a ligand-free nickel(II)-catalyzed halogen exchange of aromatic halides with magnesium chloride. This method effectively facilitates the retro-Finkelstein reaction for a wide range of aryl bromides,...

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Nickel-Catalyzed Reductive Cyanation of Aryl Halides and Epoxides with Cyanogen Bromide

Wu,

Ma,

Bilal

et al. 2024

Molecules

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Nitriles are valuable compounds because they have widespread applications in organic chemistry. This report details the nickel-catalyzed reductive cyanation of aryl halides and epoxides with cyanogen bromide for the synthesis of nitriles. This robust protocol underscores the practicality of using a commercially available and cost-effective cyanation reagent. A variety of aryl halides and epoxides featuring diverse functional groups, such as -TMS, -Bpin, -OH, -NH2, -CN, and -CHO, were successfully converted into nitriles in moderate-to-good yields. Moreover, the syntheses at gram-scale and application in late-stage cyanation of natural products and drugs reinforces its potentiality.

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Nickel-Catalyzed Reductive Cyanation of Aryl Halides and Epoxides with Cyanogen Bromide

Wu,

Ma,

Bilal

et al. 2024

Molecules

View full text Add to dashboard Cite

show abstract

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Magnesium-promoted nickel-catalysed chlorination of aryl halides and triflates under mild conditions

Abstract: In this study, we present a ligand-free nickel(II)-catalyzed halogen exchange of aromatic halides with magnesium chloride. This method effectively facilitates the retro-Finkelstein reaction for a wide range of aryl bromides,...

Cited by 1 publication

References 44 publications

Nickel-Catalyzed Reductive Cyanation of Aryl Halides and Epoxides with Cyanogen Bromide

Nickel-Catalyzed Reductive Cyanation of Aryl Halides and Epoxides with Cyanogen Bromide

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