2018
DOI: 10.1007/978-3-030-03742-0_9
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Magnesium Role in Health and Longevity

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Cited by 9 publications
(7 citation statements)
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“…Hence, it is crucial to regulate the Mg 2+ concentration ([Mg 2+ ]) within optimal levels according to the cell type and environment not only for normal functions and development but also prevention of diseases. In fact, disorder of Mg 2+ homeostasis is involved in cancer, diabetes, and neurodegenerative diseases, such as Parkinson’s disease (PD), Alzheimer’s disease (AD), and demyelination [1,2,3,8,9]. The significance of intracellular Mg 2+ is universal and fundamental at the molecular level, but its multiple and complex functions lead to its cell-type-specific roles.…”
Section: Introductionmentioning
confidence: 99%
“…Hence, it is crucial to regulate the Mg 2+ concentration ([Mg 2+ ]) within optimal levels according to the cell type and environment not only for normal functions and development but also prevention of diseases. In fact, disorder of Mg 2+ homeostasis is involved in cancer, diabetes, and neurodegenerative diseases, such as Parkinson’s disease (PD), Alzheimer’s disease (AD), and demyelination [1,2,3,8,9]. The significance of intracellular Mg 2+ is universal and fundamental at the molecular level, but its multiple and complex functions lead to its cell-type-specific roles.…”
Section: Introductionmentioning
confidence: 99%
“…Calcium and magnesium are found in drinking water of natural origin almost exclusively in the form of real ions and are thus fully accessible to the human body. In various foods, Mg is often bound in the form of complex organic compounds, and therefore its bioavailability to the human body is lower [ 55 ]. Under the insufficient intake of these elements by food and their borderline deficit, minor intake from drinking water might play a decisive health role.…”
Section: Discussionmentioning
confidence: 99%
“…The effect of low Mg content and partly also Ca in drinking water on increased mortality from oncological diseases was proved by several studies [ 55 , 57 , 58 , 59 ]. The data in our work show that the deficient Ca and Mg contents in drinking water have a significant effect on increased mortality and diseases of the digestive and respiratory system.…”
Section: Discussionmentioning
confidence: 99%
“…African Americans infected with SARS-CoV-2 have two times higher death rates than white Americans (69), twice the incidence of hypomagnesemia (43), and in about 76% a vitamin D deficiency mainly due to the fact that pigmentation reduces vitamin D production in the skin (25). While Mg deficiency may occur without hypomagnesemia, when present, it is usually indicative of an important systemic Mg deficit (8). Hypophosphatemia can exist when total stores are low, normal, or high.…”
Section: Main Textmentioning
confidence: 99%
“…Another intriguing observation is that renal phosphate and Mg reabsorption and, consequently, serum phosphate [−20% for men comparing 20 vs. 70 yr ( 29 )] and cellular Mg [−13% comparing <65 and >65 yr, −23% for >65 yr with non-insulin-dependent diabetes mellitus ( 30 )] levels decline with age [age > 53: C-OR, 2.59 ( 21 )]. For phosphate, this decline is much stronger in older men than in older women ( 29 ), which is in line with COVID-19 complications being more severe in older men.…”
Section: Main Textmentioning
confidence: 99%