Magnesium Status and Stress: The Vicious Circle Concept Revisited

Pickering, Gisèle; Mazur, Andrzej; Trousselard, Marion; Bieńkowski, Przemysław; Yaltsewa, Natalia; Amessou, Mohamed; Noah, Lionel; Pouteau, Etienne

doi:10.3390/nu12123672

Cited by 89 publications

(90 citation statements)

References 130 publications

(231 reference statements)

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“…In forty-five percent of subjects, the daily intake was less than seventy-five percent of the RDA, and in nineteen percent the daily intake was less than fifty percent of the RDA [ 16 ]. In Europe, the situation is similar [ 15 ]. Even in physically active and well-educated European women, dietary recommendations are not followed [ 17 ].…”

Section: Mg Deficiencies Associated With Reduced Mg Intakementioning

confidence: 99%

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Magnesium in Aging, Health and Diseases

2021

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Several changes of magnesium (Mg) metabolism have been reported with aging, including diminished Mg intake, impaired intestinal Mg absorption and renal Mg wasting. Mild Mg deficits are generally asymptomatic and clinical signs are usually non-specific or absent. Asthenia, sleep disorders, hyperemotionality, and cognitive disorders are common in the elderly with mild Mg deficit, and may be often confused with age-related symptoms. Chronic Mg deficits increase the production of free radicals which have been implicated in the development of several chronic age-related disorders. Numerous human diseases have been associated with Mg deficits, including cardiovascular diseases, hypertension and stroke, cardio-metabolic syndrome and type 2 diabetes mellitus, airways constrictive syndromes and asthma, depression, stress-related conditions and psychiatric disorders, Alzheimer’s disease (AD) and other dementia syndromes, muscular diseases (muscle pain, chronic fatigue, and fibromyalgia), bone fragility, and cancer. Dietary Mg and/or Mg consumed in drinking water (generally more bioavailable than Mg contained in food) or in alternative Mg supplements should be taken into consideration in the correction of Mg deficits. Maintaining an optimal Mg balance all through life may help in the prevention of oxidative stress and chronic conditions associated with aging. This needs to be demonstrated by future studies.

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Section: Mg Deficiencies Associated With Reduced Mg Intakementioning

confidence: 99%

“…A number of enzymes and cellular reactions involved in stress responses are Mg-dependent [ 15 ]. Serum Mg levels have been proposed to be reduced in subjects with depression [ 138 ].…”

Section: Mg and Psychiatric Disordersmentioning

confidence: 99%

Magnesium in Aging, Health and Diseases

2021

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“…In addition, stress conditions can result in an increased loss of magnesium from tissues causing an increase in the concentration of extracellular magnesium [27]. Subsequently, this increase in extracellular magnesium can lead to increased magnesium urinary excretion and deficiency.…”

Section: Univariate Analysismentioning

confidence: 99%

Dysmagnesemia in Covid-19 cohort patients: prevalence and associated factors

Quilliot¹,

Bonsack²,

Jaussaud³

et al. 2020

Magnesium Research

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Hypomagnesemia and hypermagnesemia could have serious implications and possibly lead to progress from a mild form to a severe outcome of Covid-19. Susceptibility of subjects with low magnesium status to develop and enhance this infection is possible. There is little data on the magnesium status of patients with Covid-19 with different degrees of severity. This study was conducted to evaluate prevalence of dysmagnesemia in a prospective Covid-19 cohort study according to the severity of the clinical manifestations and to identify factors associated. Serum magnesium was measured in 300 of 549 patients admitted to the hospital due to severe Covid-19. According to the WHO guidelines, patients were classified as moderate, severe, or critical. 48% patients had a magnesemia below 0.75 mmol/L (defined as magnesium deficiency) including 13% with a marked hypomagnesemia (<0.65 mmol/L). 9.6% had values equal to or higher than 0.95 mmol/L. Serum magnesium concentrations were significantly lower in female than in male (0.73 AE 0.12 vs 0.80 AE 0.13 mmol/L), whereas the sex ratio M/F was higher in severe and critical form (p<0.001). In a bivariate analysis, the risk of magnesium deficiency was significantly and negatively associated with infection severity (p<0.001), sex ratio (M/F, p<0.001), oxygenotherapy (p<0.001), stay in critical care unit (p=0.028), and positively with nephropathy (p=0.026). Logistic regression analysis revealed that the strongest predictors of magnesium deficiency were female sex (OR=2.67, p<0.001) and nephropathy (OR=2.12, p=0.032) and after exclusion of sex ratio, the severity of infection (OR=0.46, p=0.04 and OR=0.39 p=0.01), for critical and moderate forms, respectively. This transversal study reveals a high prevalence of hypomagnesemia in hospitalized patients for Covid-19, while high-level serum magnesium concentration was more prevalent in critical form.

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“…Several ongoing clinical trials tackle pain alleviation by addressing the impact of Mg on stress in painful patients. An ongoing RCT, Semafor (NCT0388700) explores stress, pain and sleep in fibromyalgia patients, focusing on the central role of Mg in the vicious circle of stress and pain [ 5 ]. Another ongoing RCT, Magritte (NCT04391452), is studying the impact of a Mg-based dietary supplement on stress, pain and comorbidities with a double approach, clinical and mechanistic with functional magnetic resonance imaging (fMRI) neuroimaging.…”

Section: Discussionmentioning

confidence: 99%

Magnesium for Pain Treatment in 2021? State of the Art

et al. 2021

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Background: Magnesium (Mg) is commonly used in clinical practice for acute and chronic pain and has been reported to reduce pain intensity and analgesics consumption in a number of studies. Results are, however, contested. Objectives: This review aims to investigate randomised clinical trials (RCTs) on the effectiveness of Mg treatment on pain and analgesics consumption in situations including post-operative pain, migraine, renal pain, chronic pain, neuropathic pain and fibromyalgia. Results: The literature search identified 81 RCTs (n = 5447 patients) on Mg treatment in pain (50 RCTs in post-operative pain, 18 RCTs in migraine, 5 RCTs in renal pain, 6 RCTs in chronic/neuropathic pain, 2 RCTs in fibromyalgia). Conclusion: The level of evidence for the efficacy of Mg in reducing pain and analgesics consumption is globally modest and studies are not very numerous in chronic pain. A number of gaps have been identified in the literature that need to be addressed especially in methodology, rheumatic disease, and cancer. Additional clinical trials are needed to achieve a sufficient level of evidence and to better optimize the use of Mg for pain and pain comorbidities in order to improve the quality of life of patients who are in pain.

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Magnesium Status and Stress: The Vicious Circle Concept Revisited

Cited by 89 publications

References 130 publications

Magnesium in Aging, Health and Diseases

Magnesium in Aging, Health and Diseases

Dysmagnesemia in Covid-19 cohort patients: prevalence and associated factors

Magnesium for Pain Treatment in 2021? State of the Art

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