Magnesium substitution in carbonated hydroxyapatite: Structural and microstructural characterization by Rietveld's refinement

Lala, S.; Ghosh, Moumita; Das, Prasanta Kumar; Das, Dipankar; Kar, Tanusree; Pradhan, S.K.

doi:10.1016/j.matchemphys.2015.12.058

Cited by 58 publications

(27 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[1][2][3][4][5] Although, stoichiometric HA, composed of calcium (Ca), phosphates (PO 4 ), and hydroxyl (OH) groups [Ca 10 (PO 4 ) 6 (OH) 2 ], the chemical composition of biological apatites differs from the stoichiometric HA. [6][7][8][9] The biological apatites are uniquely similar in that they all comprise carbonate (CO 3 ) in varying amounts of 2-8 wt %, preferentially substituting the PO 4 site (B-type) compared with OH (A-type) ions in the apatite lattice. [9][10][11][12][13] The composition of CO 3 depends on bone age, site, sex, and health of the individual.…”

Section: Introductionmentioning

confidence: 99%

“…[6][7][8][9] The biological apatites are uniquely similar in that they all comprise carbonate (CO 3 ) in varying amounts of 2-8 wt %, preferentially substituting the PO 4 site (B-type) compared with OH (A-type) ions in the apatite lattice. [9][10][11][12][13] The composition of CO 3 depends on bone age, site, sex, and health of the individual. 8,14,15 The beneficial impact of CO 3 substitution into PO 4 and/ or OH site in HA structure has been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Development of multisubstituted hydroxyapatite nanopowders as biomedical materials for bone tissue engineering applications

Ismail

Wimpenny

Bretcanu

et al. 2017

J Biomedical Materials Res

View full text Add to dashboard Cite

Ionic substitutions have been proposed as a tool to control the functional behavior of synthetic hydroxyapatite (HA), particularly for Bone Tissue Engineering (BTE) applications. The effect of simultaneous substitution of different levels of carbonate (CO 3 ) and silicon (Si) ions in the HA lattice was investigated. Furthermore, human bone marrow-derived mesenchymal stem cells (hMSCs) were cultured on multi-substituted HA (SiCHA) to determine if biomimetic chemical compositions were osteoconductive. Of the four different compositions investigates, SiCHA-1 (0.58wt% Si) and SiCHA-2 (0.45wt% Si) showed missing bands for CO 3 and Si using FTIR analysis, indicating competition for occupation of the phosphate site in the HA lattice. 500°C was considered the most favourable calcination temperature as: (i) the powders produced possessed a similar amount of CO 3 (2-8wt%) and Si (<1.0wt%) as present in native bone; and (ii) there was a minimal loss of CO 3 and Si from the HA structure to the surroundings during calcination. Higher Si content in SiCHA-1 led to lower cell viability and at most hindered proliferation, but no toxicity effect occurred.While, lower Si content in SiCHA-2 showed the highest ALP/DNA ratio after 21 days culture with hMSCs, indicating that the powder may stimulate osteogenic behaviour to a greater extent than other powders.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of multisubstituted hydroxyapatite nanopowders as biomedical materials for bone tissue engineering applications

Ismail

Wimpenny

Bretcanu

et al. 2017

J Biomedical Materials Res

View full text Add to dashboard Cite

show abstract

“…Hydroxyapatite (HA) (Ca 10 (PO 4 ) 6 (OH) 2 is the inorganic component of bones that have excellent biocompatibility with a lot of application in biomedical fields and act as filler due to its characteristics. These are similar to mineral component that present in bones and hard tissues [1].…”

Section: Introductionmentioning

confidence: 99%

“…These are similar to mineral component that present in bones and hard tissues [1]. The combination of ceramic based materials such as hydroxyapatite and natural polymer as sodium alginate will provide strength, stiffness and fracture toughness to the bone [2,3].The composite materials have been used in load bearing application such as filler and bone defect.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Sintering Temperature on Densification and Mechanical Properties of Hydroxyapatite/Sodium Alginate Biocomposites

et al. 2017

View full text Add to dashboard Cite

Abstract. Hydroxyapatite (HA) has been studied for their excellent performances which are suitable for use in bone defects or regeneration of bone. Hydroxyapatite (HA) has poor mechanical properties which make it limited used in a load bearing area. In this case, sodium alginate (SA) was used to be mixed with hydroxyapatite (HA) by using precipitation method to increase the mechanical and physical properties. The mixing of hydroxyapatite/sodium alginate effectively increases the densification and hardness of hydroxyapatite. It could contribute to the development of the artificial implants of hydroxyapatite (HA) for bone implants applications in load bearing area. The behaviors during densification were studied together with the mechanical properties of samples. The influence of mixed powder and the sintering temperature on densification, microstructure and mechanical properties of hydroxyapatite (HA)/sodium alginate (SA) composite were studied. The maximum density were attained by 99.5/0.5% (HA/SA) at 1.47g/cm3 and 1.82g/cm3 for both temperature 1000°C and 1100°C respectively while, the maximum values of hardness were also attained by 99.5/0.5% for temperature 1000°C and 1100°C at 0.053GPa and 0.266GPa respectively.

show abstract

“…Neste sentido, os mesmos ocorrem devido ao princípio de neutralidade de carga para acomodar espécies com distintas valências. A rede cristalina da HA hexagonal pode expandir ou contrair consideravelmente na presença de substituições iônicas e vacâncias em relação a sua versão pura e estequiométrica, e valores do parâmetro a entre 9,41 e 9,44 Å e do parâmetro c entre 6,84 e 6,94 Å são relatados na literatura [13,16,35,[42][43][44].…”

Section: -Flexibilidade E Desordem Estrutural Na Hidroxiapatitaunclassified

Estudo, caracterização e propriedades de ortofosfatos multifuncionais

Machado¹

View full text Add to dashboard Cite

Magnesium substitution in carbonated hydroxyapatite: Structural and microstructural characterization by Rietveld's refinement

Cited by 58 publications

References 38 publications

Development of multisubstituted hydroxyapatite nanopowders as biomedical materials for bone tissue engineering applications

Development of multisubstituted hydroxyapatite nanopowders as biomedical materials for bone tissue engineering applications

The Effects of Sintering Temperature on Densification and Mechanical Properties of Hydroxyapatite/Sodium Alginate Biocomposites

Estudo, caracterização e propriedades de ortofosfatos multifuncionais

Contact Info

Product

Resources

About