Magnesium sulfate improves postoperative analgesia in laparoscopic gynecologic surgeries: a double-blind randomized controlled trial

Sousa, Ângela Maria; Rosado, Giovanna M.C.; Neto, José de Santana; Guimarães, Gabriel Magalhães Nunes; Ashmawi, Hazem Adel

doi:10.1016/j.jclinane.2016.05.006

Cited by 35 publications

(34 citation statements)

References 30 publications

(27 reference statements)

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“…These effects mediated through its antinociceptive properties as a noncompetitive N-methyl-D-aspartate receptor antagonist. [ 6 7 8 9 10 11 12 ] In addition to its role in procedures that necessitate deliberate hypotension as it acted as a calcium channel blocker and direct vasodilator. [ 13 14 ] Hence, it possibly controls the undesirable effects of succinylcholine and endotracheal intubation such as increased IOP, hypertension, and tachycardia.…”

Section: Introductionmentioning

confidence: 99%

The influence of two different doses of magnesium sulfate on intraocular pressure variations after injection of succinylcholine and endotracheal intubation: A prospective, randomized, parallel three-arm, double-blind, placebo-controlled clinical trial

et al. 2017

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Background:The use of succinylcholine for rapid sequence induction in patients with open globe injuries may be detrimental to the eye.Aim:The aim of this study is to determine if the premedication with magnesium sulfate (MgSO4) could attenuate the increase in intraocular pressure (IOP) associated with succinylcholine injection and intubation.Setting:Operation theaters in a tertiary care University Hospital between December 2014 and July 215.Design:This was a prospective, randomized, parallel three-arm, double-blind, placebo-controlled clinical trial.Participants:One hundred and thirteen patients’ physical status ASA Classes I and II underwent elective cataract surgery under general anesthesia.Patients and Methods:These patients allocated into three groups: Group C (control group) received 100 ml normal saline, Group M1 received 30 mg/kg MgSO4 in 100 ml normal saline, and Group M2 received 50 mg/kg MgSO4 in 100 ml normal saline. IOP, mean arterial pressure (MAP), and heart rate (HR) reported at 5-time points related to study drug administration. In addition, any adverse effects related to MgSO4 were recorded. Intragroup and between-groups differences were examined by analysis of variance test.Results:We noticed a significant decrease in IOP in M1 (n = 38) and M2 (n = 37) groups as compared with C group (n = 38) after study drugs infusion, 2 and 5 min after intubation, P < 0.001. While the difference between M1 and M2 groups was insignificant, P = 0.296 and P = 0.647, respectively. There was a significant decrease in MAP and HR in M1 and M2 groups as compared with C group 2 and 5 min after intubation, P = 0.01. While the difference between M1 and M2 groups was insignificant, P = 1.Conclusion:MgSO4 30 mg/kg as well as 50 mg/kg effectively prevented the rise in IOP, MAP, and HR associated with rapid sequence induction by succinylcholine and endotracheal intubation.

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Section: Introductionmentioning

confidence: 99%

The influence of two different doses of magnesium sulfate on intraocular pressure variations after injection of succinylcholine and endotracheal intubation: A prospective, randomized, parallel three-arm, double-blind, placebo-controlled clinical trial

et al. 2017

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“…Furthermore, we did not apply equianalgesic doses for the comparison of analgesic efficacy. Some clinical studies have compared magnesium sulfate to ketorolac [ 10 ] and fentanyl [ 28 ]. In addition, rofecoxib, celecoxib, and acetaminophen have been examined in comparison to vitamin C following various surgical procedures [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…Several clinical studies have reported that perioperative administration of magnesium or high-dose vitamin C can reduce postoperative opioid requirements [ 5 , 9 ]. Some studies compared the analgesic efficacy of magnesium sulfate with that of other drugs [ 10 – 12 ]. Other studies focused on vitamin C also included some comparisons [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Additional effect of magnesium sulfate and vitamin C in laparoscopic gynecologic surgery for postoperative pain management: a double-blind randomized controlled trial

et al. 2020

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Background This clinical trial was conducted to determine whether combined use of magnesium sulfate and vitamin C more significantly reduced postoperative fentanyl consumption and pain than magnesium sulfate or vitamin C alone. Methods The prospective, double-blinded, randomized controlled study enrolled 132 patients scheduled for laparoscopic gynecologic surgery. The patients were randomly allocated to one of the four groups (n = 33 for each group; Group M [magnesium sulfate 40 mg/kg], Group V [vitamin C 50 mg/kg], Group MV [magnesium sulfate 40 mg/kg and vitamin C 50 mg/kg] and Group C [isotonic saline 40 ml]). Cumulative postoperative fentanyl consumption (primary endpoint measure), postoperative pain score by numeric rating scale, and postoperative nausea and vomiting were recorded at 1, 6, 24, and 48 h after discharge from the postanesthesia care unit. Results Cumulative postoperative fentanyl consumption was significantly less in Groups M, V, and MV than in Group C at all time points. Group MV showed significantly less cumulative postoperative fentanyl consumption than Group M at postoperative 24 h (mean ± standard deviation, 156.6 ± 67.5 vs. 235.6 ± 94.6 µg, P = 0.001), as well as significantly less consumption than Groups M and V at postoperative 48 h (190.8 ± 74.6 vs. 301.0 ± 114.8 or 284.1 ± 128.6 µg, P < 0.001, P = 0.003, respectively). Conclusions Combined use of magnesium sulfate and vitamin C provides an additional benefit in postoperative pain management after laparoscopic gynecologic surgery in comparison to single administration of magnesium sulfate or vitamin C.

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“…One of explanations is the increased discomfort and aggravates postoperative pain by shivering [21] . In addition, the prevention of shivering and low PONV may attenuate postoperative pain and enhance patients' satisfaction [24] .…”

Section: Discussionmentioning

confidence: 99%

The Beneficial Effects of Adding Magnesium Sulphate to General Anesthesia for Laparoscopic Sleeve Gastrectomy

Ali

Ragab

Diab

2020

International Journal of Medical Arts

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Magnesium sulfate improves postoperative analgesia in laparoscopic gynecologic surgeries: a double-blind randomized controlled trial

Cited by 35 publications

References 30 publications

The influence of two different doses of magnesium sulfate on intraocular pressure variations after injection of succinylcholine and endotracheal intubation: A prospective, randomized, parallel three-arm, double-blind, placebo-controlled clinical trial

The influence of two different doses of magnesium sulfate on intraocular pressure variations after injection of succinylcholine and endotracheal intubation: A prospective, randomized, parallel three-arm, double-blind, placebo-controlled clinical trial

Additional effect of magnesium sulfate and vitamin C in laparoscopic gynecologic surgery for postoperative pain management: a double-blind randomized controlled trial

The Beneficial Effects of Adding Magnesium Sulphate to General Anesthesia for Laparoscopic Sleeve Gastrectomy

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