Magnesium supplementation helps to improve carotid intima media thickness in patients on hemodialysis

Turgut, Faruk; Kanbay, Mehmet; Metin, Melike Ruşen; Uz, Ebru; Akçay, Ali; Covic, Adrian

doi:10.1007/s11255-008-9410-3

Cited by 143 publications

(134 citation statements)

References 34 publications

Supporting

Mentioning

122

Contrasting

Unclassified

Order By: Relevance

“…In accordance with these findings, a recent study in hemodialysis patients showed that magnesium oxide for 6 months was able to decrease carotid IMT with an increase in the placebo group [57]. Indeed, the role of magnesium in attenuating the progression of atherosclerosis has been previously demonstrated in hemodialysis patients [58].…”

Section: Discussionsupporting

confidence: 60%

Oral magnesium supplementation improves endothelial function and attenuates subclinical atherosclerosis in thiazide-treated hypertensive women

Cunha

d'El-Rei

Medeiros

et al. 2017

Journal of Hypertension

View full text Add to dashboard Cite

Oral magnesium supplementation improves endothelial function and attenuates subclinical atherosclerosis in thiazide-treated hypertensive women. Journal of Hypertension, 35(1), pp. 89-97.There may be differences between this version and the published version. You are advised to consult the publisher's version if you wish to cite from it.http://eprints.gla.ac.uk/130809/ Condensed AbstractThis study evaluated the effects of magnesium supplementation on blood pressure (BP) and vascular function in thiazide-treated hypertensive women, mean 24-h BP≥130/80 mmHg, in a randomized, double-blind, clinical trial comparing placebo and magnesium chelate 600 mg/day supplementation. Brachial flow-mediated dilatation (FMD) and central hemodynamic parameters were measured at inclusion and after 6 months. The magnesium group demonstrated a significant reduction in systolic and diastolic BP, and a significant increase in variation of FMD versus the placebo group (+3.7±2.1 vs 2.4±1.2 %, p=0.015). In conclusion, magnesium supplementation was associated with better BP control and improved endothelial function in thiazide-treated hypertensive. AbstractEpidemiological studies demonstrate an inverse association between serum magnesium and incidence of cardiovascular disease. Diuretics commonly cause hypomagneseamia.We evaluated effects of magnesium supplementation on blood pressure (

show abstract

Section: Discussionsupporting

confidence: 60%

Oral magnesium supplementation improves endothelial function and attenuates subclinical atherosclerosis in thiazide-treated hypertensive women

Cunha

d'El-Rei

Medeiros

et al. 2017

Journal of Hypertension

View full text Add to dashboard Cite

show abstract

“…At the end of the study, the number of patients with improved carotid IMT was significantly higher in the Mg-containing phosphate binder group than in the Ca-containing binder group (P = 0.04). Turgut et al also showed the beneficial effects of Mg supplementation [76]. However, these findings appeared to be inconclusive because of the relatively small sample size as well as the accuracy and reproducibility of the evaluation methods.…”

Section: Mg-containing Phosphate Bindersmentioning

confidence: 99%

Cardiovascular disease, mortality, and magnesium in chronic kidney disease: growing interest in magnesium-related interventions

Ikee¹

2018

Ren Replace Ther

View full text Add to dashboard Cite

Magnesium (Mg) is an essential element that plays pivotal roles in a number of biological processes in the human body. Hypomagnesemia is involved in the pathophysiology of hypertension, vascular calcification, and metabolic derangements including diabetes mellitus and dyslipidemia, which are all risk factors for cardiovascular disease, the leading cause of mortality and morbidity in patients with chronic kidney disease (CKD). Hypomagnesemia is also associated with the development and progression of CKD. As CKD advances, renal Mg excretion decreases and hypermagnesemia emerges in end-stage renal disease (ESRD). In addition, dialysates with high Mg concentrations, which were used in the early era of dialysis therapy, increased the risk of hypermagnesemia, and thus, the dialysate Mg composition has since been reduced. Accordingly, dialysis patients in the modern era commonly have normomagnesemia or even hypomagnesemia. The relationships between hypomagnesemia and cardiovascular disease and mortality have been increasingly reported in observational studies in CKD/ESRD. However, these relationships may be attenuated by a patient's race or region. Although dialysates with higher Mg concentrations or Mg-containing phosphate binders appear to be promising in this setting, only a few interventional studies have examined the effects of Mg supplementation on cardiovascular lesions. Furthermore, the effects of Mg supplementation on mortality have not yet been investigated as a primary end-point in randomized controlled trials. Further studies are required in order to establish the efficacy and safety of Mg in CKD patients.

show abstract

“…Observational studies had shown that low serum Mg may be an independent risk factor for premature death in CKD patients and patients with mildly elevated serum levels could have a better chance of survival over those with lower Mg levels. It has been suggested that Mg supplementation might be useful in reducing the progression of atherosclerosis in chronic dialysis patients (Turgut et al, 2008). …”

Section: +mentioning

confidence: 99%

Groundwater fluoride as a geochemical marker in the etiology of chronic kidney disease of unknown origin in Sri Lanka

Dissanayake

Chandrajith

2017

Ceylon J. Sci.

View full text Add to dashboard Cite

show abstract

Magnesium supplementation helps to improve carotid intima media thickness in patients on hemodialysis

Abstract: Based on the present data, magnesium may play an important protective role in the progression of atherosclerosis in patients on dialysis. Further studies are needed to assess more accurately the role of magnesium in atherosclerotic regression in dialysis patients.

Cited by 143 publications

References 34 publications

Oral magnesium supplementation improves endothelial function and attenuates subclinical atherosclerosis in thiazide-treated hypertensive women

Oral magnesium supplementation improves endothelial function and attenuates subclinical atherosclerosis in thiazide-treated hypertensive women

Cardiovascular disease, mortality, and magnesium in chronic kidney disease: growing interest in magnesium-related interventions

Groundwater fluoride as a geochemical marker in the etiology of chronic kidney disease of unknown origin in Sri Lanka

Contact Info

Product

Resources

About