Magnesium supplementation in the treatment of pseudoxanthoma elasticum: A randomized trial

Rose, Sharon; On, Shelbi Jim; Fuchs, W.K.; Chen, Chen; Phelps, Robert; Kornreich, Davida; Haddican, Madelaine; Singer, Giselle; Wong, Vicky; Baum, Danielle; Vekaria, Anjali S.; Gagliotti, Matthew; Huang, Ruiqi; Suárez‐Fariñas, Mayte; Terry, Sharon F.; Lebwohl, Mark

doi:10.1016/j.jaad.2019.02.055

Cited by 15 publications

(17 citation statements)

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“…Indeed, magnesium is effective against elastic tissue calcification in PXE mouse models. 1 However, in this study, we regret that magnesium treatment results in only a trend toward improvement. 1 So, various factors might account for lack of statistical effect beyond a small sample size.…”

mentioning

confidence: 62%

“…1 However, in this study, we regret that magnesium treatment results in only a trend toward improvement. 1 So, various factors might account for lack of statistical effect beyond a small sample size. Magnesium supplements and magnesium salt are combinations of magnesium and other minerals and come in 4 different forms: insoluble inorganic salts (oxide carbonate hydroxide), soluble inorganic salts (chloride sulfate), soluble organic salts (citrate lactate gluconate), and soluble organic complexes ( glycinate bisglycinate).…”

mentioning

confidence: 62%

“…To the Editor: We read with great interest Rose et al's 1 report on their randomized controlled trial on magnesium supplementation to treat pseudoxanthoma elasticum (PXE). Indeed, magnesium is effective against elastic tissue calcification in PXE mouse models.…”

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confidence: 99%

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Comment on “Magnesium supplementation in the treatment of pseudoxanthoma elasticum:” Is magnesium oxide the best choice?

Omarjee

Unger²

2019

Journal of the American Academy of Dermatology

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Comment on “Magnesium supplementation in the treatment of pseudoxanthoma elasticum:” Is magnesium oxide the best choice?

Omarjee

Unger²

2019

Journal of the American Academy of Dermatology

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“…In a quite similar way, magnesium-which has a known but mechanistically unexplained inhibitory effect on calcification-came up as a potential treatment, as it was shown that increasing the magnesium content in the diet of PXE mice prevented tissue mineralization [182,184,185]. A prospective clinical trial in PXE patients, using oral magnesium oxide, did, however, not reveal any substantial benefits of magnesium supplementation [186].…”

Section: Early Treatment Possibilitiesmentioning

confidence: 99%

From membrane to mineralization: the curious case of the ABCC6 transporter

et al. 2020

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ATP‐binding cassette subfamily C member 6 gene/protein (ABCC6) is an ATP‐dependent transmembrane transporter predominantly expressed in the liver and the kidney. ABCC6 first came to attention in human medicine when it was discovered in 2000 that mutations in its encoding gene, ABCC6, caused the autosomal recessive multisystemic mineralization disease pseudoxanthoma elasticum (PXE). Since then, the physiological and pathological roles of ABCC6 have been the subject of intense research. In the last 20 years, significant findings have clarified ABCC6 structure as well as its physiological role in mineralization homeostasis in humans and animal models. Yet, several facets of ABCC6 biology remain currently incompletely understood, ranging from the precise nature of its substrate(s) to the increasingly complex molecular genetics. Nonetheless, advances in our understanding of pathophysiological mechanisms causing mineralization lead to several treatment options being suggested or already tested in pilot clinical trials for ABCC6 deficiency. This review highlights current knowledge of ABCC6 and the challenges ahead, particularly the attempts to translate basic science into clinical practice.

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“…Finally, PXE International was a collaborator in a study to determine whether magnesium is a viable treatment for PXE [16].…”

Section: Role Of Pxe International In Catalysing Research On Abcc6 Anmentioning

confidence: 99%

The Human Face of ABCC6

Terry

2020

FEBS Letters

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Researchers working on basic and translational clinical science related to ABC transporters are enthusiastic and dedicated investigators. As the field has grown, so has its contribution to human disease. Pseudoxanthoma elasticum (PXE) International, an advocacy organization established by non-scientists, began supporting research and convenings on these transporters, specifically ABCC6, the gene associated with PXE, 20 years ago. As a patient advocacy organization, we have spent more than 25 years creating a large research consortium, initiating, funding and conducting research. Years of basic modelling and vigorous hypothesis testing have resulted in some important advances leading to clinical trials. The synergy of basic scientists, lay advocates, clinicians and translational scientists has dramatically accelerated research on PXE and progress towards better and more effective treatments for PXE patients.

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Magnesium supplementation in the treatment of pseudoxanthoma elasticum: A randomized trial

Cited by 15 publications

References 5 publications

Comment on “Magnesium supplementation in the treatment of pseudoxanthoma elasticum:” Is magnesium oxide the best choice?

Comment on “Magnesium supplementation in the treatment of pseudoxanthoma elasticum:” Is magnesium oxide the best choice?

From membrane to mineralization: the curious case of the ABCC6 transporter

The Human Face of ABCC6

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