Magnesium taurate attenuates progression of hypertension and cardiotoxicity against cadmium chloride-induced hypertensive albino rats

Shrivastava, Parikshit; Choudhary, Rajesh; Nirmalkar, Umashankar; Singh, Amrita; Shree, Jaya; Vishwakarma, Prabhat Kumar; Bodakhe, Surendra H.

doi:10.1016/j.jtcme.2017.06.010

Cited by 8 publications

(4 citation statements)

References 43 publications

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“…Another component of DASH diet that is considered as a decreasing factor of HTN, is magnesium, which in our study was shown as a preventive factor, and ths is fully consistent with the findings of other studies [ 29 , 30 ].…”

Section: Discussionsupporting

confidence: 93%

Investigating the prevalence of hypertension and its associated risk factors in a population-based study: Fasa PERSIAN COHORT data

Bijani

Parvizi

Dehghan

et al. 2020

BMC Cardiovasc Disord

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Background A high prevalence rate of hypertension (HTN) and its subsequent serious complications made this disease a major health-treatment concern in many societies. The current study aimed to investigate the prevalence of hypertension and its associated risk factors in Fasa PERSIAN COHORT in south of Iran in 2019. Methods This was an analytical-cross sectional study. The study population were the individuals covered by Fasa cohort. Information of the first phase of Fasa Persian cohort in south of Iran was used in this study. Independent t test, chi-square test, analysis of variances, Pearson correlation coefficient, and multiple stepwise regression were used to analyze the obtained data. Thereafter, the data was analyzed using SPSS software version 22, and P value < 0.05 was considered as statistically significant. Results Out of 10,111 individuals included in the study, 5546 (54.86%) subjects were women and 4565 (45.16%) other were men. The overall prevalence rate of hypertension was estimated as 46.6%. In the present study, (16/1%) of the participants were with HTN stage 1, and (17/9%) of them were with HTN stage 2. The results show that there were significant positive correlations among HTN and age, BMI, HDL, TG, BUN, ALP, smoking, physical activity, cardiovascular diseases, diabetes, and renal failure (P < 0.5). Conclusions Prevalence of HTN in this study population is considerable. Therefore, it is suggested that health system should program some plans to prevent hypertension’s prevalence and eliminate its risk factors.

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Section: Discussionsupporting

confidence: 93%

Investigating the prevalence of hypertension and its associated risk factors in a population-based study: Fasa PERSIAN COHORT data

Bijani

Parvizi

Dehghan

et al. 2020

BMC Cardiovasc Disord

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“…These results are similar to those reported previously [68][69][70]. It has been demonstrated by some researchers that exposure to Cd can either inhibit these enzymes transiently or may interfere with their expression during transcriptional event [71].…”

Section: Discussionsupporting

confidence: 92%

Cardioprotective Effect of Eugenol Against Cd-Induced Inflammation, Oxidative Stress, and Dyslipidemia in Male Rats: An In Vivo and Molecular Docking Study

Kumar,

Sharma

2024

Biol Trace Elem Res

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BackgroundCadmium, a highly toxic heavy metal, can cause severe damage to several vital organs including the kidney, liver and brain. Many of the natural compounds found in aromatic plants have bene cial pharmacological properties, Eugenol, is one such compound reported to have anti-in ammatory and antioxidant properties. This study aimed to examine the potential of eugenol in alleviating cardiac in ammation, oxidative stress and dyslipidemia caused by cadmium exposure. MethodsMale albino rats were randomized into four groups with six animals in each group, to examine the role of eugenol in reversing cadmium toxicity. All groups received oral gavage treatment for 21 days. Afterwards, heart tissues were collected from the rats. Assessment of the cardiac antioxidant status was performed by analyzing the enzymatic activities of Catalase, SOD, GST and GPx. Levels of lipid peroxidation, reduced glutathione, protein carbonyl oxidation, and thiol levels were determined in heart tissue. To evaluate cardiac damage, marker enzymes such as LDH and CK-MB were measured. Cadmium-induced cardiac in ammation was assessed by measuring NO, TNF-α and IL-6 levels. Docking and molecular dynamics studies were conducted using autodock and GLIDE. ResultsCadmium administration markedly enhanced the activities of LDH and CK-MB, prominent cardiac markers. Furthermore, cadmium treatment also demonstrated a signi cant decrease in the reduced glutathione levels and antioxidant enzyme activities. Signi cant elevation of the in ammatory markers was also observed in the cadmium-treated group. Eugenol treatment effectively ameliorates cadmiuminduced biochemical changes. ConclusionThis study highlights eugenol's strong anti-in ammatory and antioxidant properties. Co-supplementation of eugenol with cadmium demonstrated its protective potential against cadmium-induced cardiotoxicity.Eugenol was able to restore the cellular redox system of cadmium-treated rats to normal control levels.

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“…Another component of DASH diet which is considered as a decreasing factor of HTN is magnesium which in our study showed to be preventive factor which is fully consistent with the ndings of other studies [25][26].…”

Section: Discussionsupporting

confidence: 93%

Investigating The Risk Factors for Hypertension in A Population-Based Study: Fasa PERSIAN COHORT Data

Bijani¹,

Parvizi²,

Dehghan³

et al. 2020

Preprint

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Background: High prevalence of hypertension (HTN) and its subsequent serious complications make this disease as a major health-treatment concern in many societies. The current study aimed to investigate known factors as risk factors for hypertension and the way of their association in study population of Fasa cohort in south of Iran at 2019.Methods: This is an analytical-cross sectional study. Study population was the individuals covered by Fasa cohort. Information of the first phase of Fasa Persian cohort in south of Iran was used in the study. Independent t-test, chi-square test, analysis of variances, Pearson correlation coefficient, and logistic regression were used to analyze data. Data was analyzed using SPSS software version 22, and P-value<0.05 was considered statistically significant.Results: Out of the population of 10111 individuals of the study, 5546(54.86%) subjects were female and 4565(45.16%) were male. The overall prevalence of hypertension was 41.8 %. In the present study (28/5%) were with HTN stage 1, and (13/3%), were with HTN stage 2. In addition, a significant association was observed among HTN and cardiovascular diseases, diabetes and renal failure (p<0.5).Conclusions: prevalence of HTN in study population is considerable. Given its hazardous complications, application of appropriate methods in order to screen, prevent and treat HTN is necessary. In addition, using training programs, changing lifestyle, and promoting self-care behaviors can be effective in prevention, control, and decrease in hazardous complications caused by HTN.

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Magnesium taurate attenuates progression of hypertension and cardiotoxicity against cadmium chloride-induced hypertensive albino rats

Cited by 8 publications

References 43 publications

Investigating the prevalence of hypertension and its associated risk factors in a population-based study: Fasa PERSIAN COHORT data

Investigating the prevalence of hypertension and its associated risk factors in a population-based study: Fasa PERSIAN COHORT data

Cardioprotective Effect of Eugenol Against Cd-Induced Inflammation, Oxidative Stress, and Dyslipidemia in Male Rats: An In Vivo and Molecular Docking Study

Investigating The Risk Factors for Hypertension in A Population-Based Study: Fasa PERSIAN COHORT Data

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