Magnesium, Zinc, and Copper in Dialysis Patients

Mahler, Delmar J.; Walsh, John R.; Haynie, Gordon

doi:10.1093/ajcp/56.1.17

Cited by 62 publications

(24 citation statements)

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“…In patients on periodic hemodialysis our Bustamante/Mateo/De Paula de Pedro/Manchado basal values of copper and ceruloplasmin are similar to those of Mansouri et al [6], although other authors found higher values [3,7]. In spite of statements of the contrary [6], we found that the copper increased even during hemodialysis; the membranes liberated 44.44% of their copper content.…”

Section: Discussionsupporting

confidence: 84%

Changes in Copper and Ceruloplasmin in Chronic Renal Insufficiency Treated by Hemodialysis and Peritoneal Dialysis

Bustamante

Mateo

Pedro

et al. 1978

Nephron

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Serum copper and ceruloplasmin as well as other parameters in 68 patients with chronic renal insufficiency were studied. It was found that chronic renal insufficiency increases neither the serum copper nor the serum ceruloplasmin. In the group on hemodialysis, there is a progressive increase of copper and ceruloplasmin in serum due to a liberation of 44.44% of the copper content of the membranes. In the group on periodic peritoneal dialysis, there is also an increase of serum copper during the dialysis. We do not have an explanation for this finding.

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Section: Discussionsupporting

confidence: 84%

Changes in Copper and Ceruloplasmin in Chronic Renal Insufficiency Treated by Hemodialysis and Peritoneal Dialysis

Bustamante

Mateo

Pedro

et al. 1978

Nephron

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“…The zinc metabolism is altered in chronic uremia, and it is not corrected by maintenance dialysis therapy [3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16]. Zinc supplementation has been shown to improve some abnormalities in uremic patients [8, 9, 10, 17].…”

Section: Introductionmentioning

confidence: 99%

Possible Site of Decreased Intestinal Zinc Absorption in Chronic Uremic Rats

Wang¹,

Chen²,

Chen

et al. 2001

Nephron

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Background/Aims: Previous zinc tolerance tests in uremic patients indicated decreased intestinal zinc absorption. In the present study, a zinc tolerance test was initially applied to a uremic rat model and subsequently the possible site of malabsorption investigated. Methods: Chronic uremia was induced by five-sixths nephrectomy. Both control and nephrectomized rats were divided into three groups including animals with intact intestine, removal of the jejunum, and removal of the ileum. Each rat was orally loaded with zinc sulfate (80 mg/kg) in conscious state. Blood samples were drawn before and after zinc load at different intervals during 6 h for zinc analysis. The area under the plasma zinc curve (AUC) and the maximal increase of plasma zinc level (C_max) were calculated. Results: Jejunectomy decreased both AUC and C_max in control and nephrectomized rats, whereas ileectomized animals remained, interestingly, unchanged with regard to these two parameters. Significant decreases in both AUC and C_max were observed in nephrectomized rats as compared with the control rats. Conclusions: The jejunum is the main site of zinc absorption in response to a large oral load of zinc sulfate in both normal and uremic rats. The data further suggest that five-sixths nephrectomy reduces gastrointestinal zinc absorption in rats predominantly by the ileum.

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“…Two additional and provocative clinical observations are: (a) maintenance dialysis patients are reported to have low plasma zinc levels in spite of normal erythrocyte values [27,28], and (b) maintenance dialysis pa tients carry high circulating levels of serum amyloid A [29].…”

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confidence: 99%