Magnet-guided temozolomide and superparamagnetic iron oxide-loaded nanoparticles to enhance therapeutic efficacy in a glioma model

Abstract

Background This study aimed to synthesize liposomal nanoparticles loaded with temozolomide and ferucarbotran (LTF) and evaluate their theranostic effects in a glioma model. Results The particle size and surface charge of LTF were measured to be 80 nm and − 38 mV, respectively. Additionally, the presence of ferucarbotran significantly increased the contrast agent effect in glioma in MR imaging, compared to the control group. The application of magnet-guided LTF significantly reduced tumor size compared to the control and other comparison groups. Furthermore, our results demonstrated significant inhibition of brain tumor growth and an associated increase in lifespan compared to the control group. Conclusions These findings suggest that LTF with magnetic guidance represents a novel approach to address current obstacles, such as blood-brain barrier (BBB) penetration by nanoparticles and drug resistance. Magnet-guided LTF is able to enhance therapeutic efficacy in mouse brain glioma.