Magnetic Active Agent Release System (MAARS): Evaluation of a new way for a reproducible, externally controlled drug release into the small intestine

Dietzel, Christian T.; Richert, Hendryk; Abert, Sandra; Merkel, Ute; Hippius, Marion; Stallmach, Andreas

doi:10.1016/j.jconrel.2012.04.047

Cited by 29 publications

(13 citation statements)

References 27 publications

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“…Mucoadhesive disks with layered structure for sticking to the intestinal wall to prolonging drug release duration [176][177][178] Microfabricated PMMA devices containing single or multiple microdrug reservoirs [179][180][181][182][183][184][185][186] Wireless endoscopic capsules Swallowable capsule endoscopes usually consisting of a drug reservoir, a piston, and an energy producer-transmission system for triggered drug release in the GI tract [198][199][200][201] Capsule endoscopes with a set of legs capable of active and controllable locomotion [202][203][204][205] Capsule devices with magnetic parts to release drugs controlled by the external magnetic field [207][208][209][210] Self-folding microcontainers Stimuli-responsive self-folding microdevices with patterned rigid segments connecting with flexible polymeric hinges [86,87] Transdermal delivery…”

Section: Iontophoretic Devicesmentioning

confidence: 99%

Section: Wireless Endoscopic Capsulesmentioning

confidence: 99%

“…To overcome this problem, several systems capable of active and controllable locomotion have been proposed. [207,208] The capsule was comprised of two metallic parts ( Figure 7C(e)). [202][203][204] A set of legs in the capsule can be deployed to resist peristaltic force in the GI tract such as the intestine.…”

Section: Wireless Endoscopic Capsulesmentioning

confidence: 99%

“…One of these systems uses a legged mechanism with small brushless DC motors powered by an on-board battery. [208] In magnetized state, the two metallic parts were attached to each other and kept the capsule closed when travelling through the GI tract. The experiment in a porcine colon demonstrated that the capsule with four legs could travel a distance of 15 cm in a period of 5 min, and the speed was able to be adjusted from 10 to 40 mm min −1 .…”

Section: Wireless Endoscopic Capsulesmentioning

confidence: 99%

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Microfabricated Drug Delivery Devices: Design, Fabrication, and Applications

Zhang

Jackson

Chiao

2017

Adv Funct Materials

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Microfabrication technology has enabled the development of novel controlled-release devices that possess an integration of structural, mechanical, and perhaps electronic features, which may address challenges associated with conventional delivery systems. In this feature article, microfabricated devices are described in terms of materials, mechanical design, working principles, and fabrication methods, all of which are key features for production of multifunctional, highly effective drug delivery systems. In addition, the current status and future prospects of different types of microfabricated devices for controlled drug delivery are summarized and analyzed with an emphasis on various routes of administration including ocular, oral, transdermal, and implantable systems. It is likely that microfabrication technology will continue to offer new, alternative solutions to design advanced and sophisticated drug delivery devices that promise to significantly improve medical care.

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Section: Iontophoretic Devicesmentioning

confidence: 99%

Section: Wireless Endoscopic Capsulesmentioning

confidence: 99%

Section: Wireless Endoscopic Capsulesmentioning

confidence: 99%

Section: Wireless Endoscopic Capsulesmentioning

confidence: 99%

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Microfabricated Drug Delivery Devices: Design, Fabrication, and Applications

Zhang

Jackson

Chiao

2017

Adv Funct Materials

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“…Woods et al [22] integrated a holding mechanism inside the capsule to resist to peristalsis and a needle for local drug deployment. The MAARS capsule, presented in [23], is composed of magnetic semi-hard modules and deploys a single shot of drug upon a demagnetization process. Yo et al [24] recently proposed an MCR where the drug release can be triggered through a reed switch.…”

Section: Clinical Motivation For Drug Delivery Systemsmentioning

confidence: 99%

Component based design of a drug delivery capsule robot

Beccani

Aiello

Gkotsis

et al. 2016

Sensors and Actuators A: Physical

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Since the introduction of Wireless Capsule Endoscopy (WCE) researchers have started exploring the design space of Medical Capsule Robots (MCRs): embedded micro-systems that can operate autonomously within the human body and can diagnose, prevent, monitor, and cure diseases. Although the research in the area of MCRs is an active topic and has grown exponentially, current devices provide only limited functionalities because their design process is expensive and time consuming. To open this research field to a wider community and, at the same time, create better designs through advanced tool support, in our previous works we presented a design environment for the rapid development of MCRs. In this paper, this environment was adopted to design a Drug Delivery Capsule (DDC) based on a coil-magnetpiston mechanism. The force of the coil acting on the magnetic piston and the drug release profile were modeled and assessed on bench-top with a maximum relative error below 5%. Then, in vivo trials were performed to validate the DDC functionality with a scheduled drug release profile for a 5 hours and 24 minutes procedure. The resulting design environment template is available open source for further development of drug delivery applications as well as to serve as guideline in prototyping novel MCRs addressing other clinical needs.

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