Magnetic Alginate/Chitosan Nanoparticles for Targeted Delivery of Curcumin into Human Breast Cancer Cells

Song, Wenxing; Su, Xing; Gregory, David A.; Li, Wei; Cai, Zhiqiang; Zhao, Xiubo

doi:10.3390/nano8110907

Cited by 119 publications

(63 citation statements)

References 83 publications

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“…5-flurouracil and curcumin loaded N,O-carboxymethyl chitosan nanoparticles 4 showed a sustained release and enhanced anti-cancer effects both in vitro and in vivo [29]. Song et al, 2018 [30] reported the high uptake efficiency, toxicity, and sustained release in human Caucasian breast adenocarcinoma cells (MDA-MB-231). It supported the dose-depended delivery of curcumin on cancer cells [30].…”

Section: Introductionmentioning

confidence: 99%

Curcumin-Loaded Mesoporous Silica Nanoparticles Markedly Enhanced Cytotoxicity in Hepatocellular Carcinoma Cells

Kong

Kuo

Johnson

et al. 2019

IJMS

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Curcumin, a natural polyphenol extracted from a perennial herb Curcuma longa has been verified for many physiological activities such as anti-oxidant, anti-inflammatory, and anti-tumor properties. The direct use of curcumin cytotoxicity studies are limited due to its unstable chemical structure, low bioavailability, easy oxidation, and degradation by ultraviolet (UV) light etc. Trying to overcome this problem, silica-encapsulated curcumin nanoparticles (SCNP) and chitosan with silica co-encapsulated curcumin nanoparticles (CSCNP) were prepared by silicification and biosilicification methods, respectively, and encapsulated curcumin within it. We investigated the antitumor properties of SCNP and CSCNP on different tumor cell lines. Scanning electron microscopy (SEM) analysis revealed that both SCNP and CSCNP were almost spherical in shape and the average particle size of CSCNP was 75.0 ± 14.62 nm, and SCNP was 61.7 ± 23.04 nm. The results show that CSCNP has more anti-oxidant activity as compared to curcumin and SCNP. The higher cytotoxicity towards different cancerous cell lines was also observed in CSCNP treated tumor cells. It was noted that the SCNP and CSCNP has a high percentage of IC50 values in Hep G2 cells. The encapsulation of curcumin improved instability, antioxidant activity, and antitumor activity. Our results demonstrated that nanoencapsulation of curcumin with silica and chitosan not only increase curcumin stability but also enhance its cytotoxic activity on hepatocellular carcinoma cells. On the basis of these primary studies, the curcumin-loaded nanoparticles appear to be promising as an innovative therapeutic material for the treatment of tumors.

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Section: Introductionmentioning

confidence: 99%

Curcumin-Loaded Mesoporous Silica Nanoparticles Markedly Enhanced Cytotoxicity in Hepatocellular Carcinoma Cells

Kong

Kuo

Johnson

et al. 2019

IJMS

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“…Curcumin-loaded nanoparticles showed stronger cytotoxicity to the breast cancer cell line MDA-MB-231 than breast cancer cell HDF. Therapeutic performance of curcumin was improved as compared to the free drug [108]. Sorasitthiyanukarn et al also employed alginate/chitosan nanocomplexes to deliver curcumin diglutaric acid (a prodrug of curcumin) for cancer treatment.…”

Section: Albuminmentioning

confidence: 99%

“…Hyaluronic acid, chitosan Hyaluronic acid, chitosan, microRNA-34a, doxorubicin Achieved synergistic effects; reduced drug resistance and side effects of doxorubicin [106] Gelatin, albumin Gelatin, albumin, GNF-5837 Efficient cellular uptake; improved therapeutic efficacy of GNF-5837 [107] Alginate, chitosan Alginate, chitosan, curcumin, iron oxide Controllable release; targeted delivery with the aid of magnetic field; improved therapeutic performance of curcumin [108] Alginate, chitosan Alginate, chitosan, curcumin diglutaric acid Improved protection and controlled release; enhanced cellular uptake and anticancer activity [109] Hyaluronic acid, albumin hyaluronic acid, albumin, paclitaxel…”

Section: Composition Of Nanoparticles Encapsulation Advantagesmentioning

confidence: 99%

Natural Ingredient-Based Polymeric Nanoparticles for Cancer Treatment

Wong

Chen

et al. 2020

Molecules

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Cancer is a global health challenge. There are drawbacks to conventional chemotherapy such as poor bioavailability, development of drug resistance and severe side effects. Novel drug delivery system may be an alternative to optimize therapeutic effects. When such systems consist of natural materials, they offer important advantages: they are usually highly biocompatible, biodegradable, nontoxic and nonimmunogenic. Furthermore, natural materials can be easily modified for conjugation with a wide range of therapeutic agents and targeting ligands, according to the therapeutic purpose. This article reviews different natural ingredients and their applications in drug delivery systems for cancer therapy. Firstly, an overview of the polysaccharides and protein-based polymers that have been extensively investigated for drug delivery are described. Secondly, recent advances in using various natural ingredient-based polymeric nanoparticles for cancer therapy are reviewed. The characteristics of these delivery systems are summarized, followed by a discussion of future development and clinical potential. This review aims to summarize current knowledge and provide a basis for developing effective tailor-made formulations for cancer therapy in the future.

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“…However, the poor oral bioavailability of curcumin limits its therapeutic efficacity [6,7]. In fact, its poor solubility in an aqueous medium and weak stability in alkaline pH conditions or gastrointestinal fluids restrict its availability to cross into the blood circulation by oral administration.…”

Section: Introductionmentioning

confidence: 99%

Growth-Inhibitory Effect of Chitosan-Coated Liposomes Encapsulating Curcumin on MCF-7 Breast Cancer Cells

et al. 2020

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Current anticancer drugs exhibit limited efficacy and initiate severe side effects. As such, identifying bioactive anticancer agents that can surpass these limitations is a necessity. One such agent, curcumin, is a polyphenolic compound derived from turmeric, and has been widely investigated for its potential anti-inflammatory and anticancer effects over the last 40 years. However, the poor bioavailability of curcumin, caused by its low absorption, limits its clinical use. In order to solve this issue, in this study, curcumin was encapsulated in chitosan-coated nanoliposomes derived from three natural lecithin sources. Liposomal formulations were all in the nanometric scale (around 120 nm) and negatively charged (around −40 mV). Among the three lecithins, salmon lecithin presented the highest growth-inhibitory effect on MCF-7 cells (two times lower growth than the control group for 12 µM of curcumin and four times lower for 20 µM of curcumin). The soya and rapeseed lecithins showed a similar growth-inhibitory effect on the tumor cells. Moreover, coating nanoliposomes with chitosan enabled a higher loading efficiency of curcumin (88% for coated liposomes compared to 65% for the non-coated liposomes) and a stronger growth-inhibitory effect on MCF-7 breast cancer cells.

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Magnetic Alginate/Chitosan Nanoparticles for Targeted Delivery of Curcumin into Human Breast Cancer Cells

Cited by 119 publications

References 83 publications

Curcumin-Loaded Mesoporous Silica Nanoparticles Markedly Enhanced Cytotoxicity in Hepatocellular Carcinoma Cells

Curcumin-Loaded Mesoporous Silica Nanoparticles Markedly Enhanced Cytotoxicity in Hepatocellular Carcinoma Cells

Natural Ingredient-Based Polymeric Nanoparticles for Cancer Treatment

Growth-Inhibitory Effect of Chitosan-Coated Liposomes Encapsulating Curcumin on MCF-7 Breast Cancer Cells

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