Magnetic and fluorescent Gd&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;3&lt;/sub&gt;:Yb&lt;sup&gt;3+&lt;/sup&gt;/Ln&lt;sup&gt;3+&lt;/sup&gt; nanoparticles for simultaneous upconversion luminescence/MR dual modal imaging and NIR-induced photodynamic therapy

Li, Jun; Huang, Long; Tian, Xiumei; Chen, Xiaoming; Shao, Yuanzhi; Xie, Fei; Chen, Dihu; Li, Li

doi:10.2147/ijn.s118938

Cited by 39 publications

(18 citation statements)

References 41 publications

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“…BBN, CGGG-QWAVGHLM-NH2 (7)(8)(9)(10)(11)(12)(13)(14), was synthesized using standard fluorenylmethoxycarbonyl (fmoc) chemistry solid phase peptide synthesis method by Boxin Biotechnology (Xiamen, People's Republic of China). All other chemicals were used without further purification.…”

Section: Materials and General Methodsmentioning

confidence: 99%

“…Furthermore, the C=O stretch at 1,716 cm −1 was prominent in HO-PEG-COOH and FI but disappeared in Gd 2 O 3 -FI-PEG-BBN, which is consistent with NPs coated by various carboxylic acids. 11 These data implied that PEG and FI were effectively coordinated to the surface of Gd 2 O 3 through the terminal carboxyl group. Further modification by BBN led to a new peak at 1,595 cm −1 corresponding to amide bond formation.…”

Section: Physicochemical Characterizationmentioning

confidence: 96%

“…10 These NPs can provide high longitudinal relaxivities that are equal to or even larger than clinically approved Gd-DTPA allowing more efficient contrast enhancement. 11 Moreover, Gd 2 O 3 NPs offer a versatile platform for further multifunctionalization through modifications, which makes them good candidates for active tumor targeting and multimodal imaging. 12 In this study, we report the development of a 5(6)-carboxyfluorescein (FI)-conjugated Gd 2 O 3 nanoprobe for PC cell-specific targeted molecular imaging.…”

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confidence: 99%

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Gastrin-releasing peptide receptor-targeted gadolinium oxide-based multifunctional nanoparticles for dual magnetic resonance/fluorescent molecular imaging of prostate cancer

Cui¹,

Lü²,

Yan³

et al. 2017

IJN

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Bombesin (BBN), an analog of gastrin-releasing peptide (GRP), specifically binds to GRP receptors, which are overexpressed in human prostate cancer (PC). Here, we synthesized a BBN-modified gadolinium oxide (Gd 2 O 3 ) nanoprobe containing fluorescein (Gd 2 O 3 -5(6)-carboxyfluorescein [FI]-polyethylene glycol [PEG]-BBN) for targeted magnetic resonance (MR)/optical dual-modality imaging of PC. The Gd 2 O 3 -FI-PEG-BBN nanoparticles exhibited a relatively uniform particle size with an average diameter of 52.3 nm and spherical morphology as depicted by transmission electron microscopy. The longitudinal relaxivity (r 1 ) of Gd 2 O 3 -FI-PEG-BBN (r 1 =4.23 mM −1 s −1 ) is comparable to that of clinically used Magnevist (Gd-DTPA). Fluorescence microscopy and in vitro cellular MRI demonstrated GRP receptor-specific and enhanced cellular uptake of the Gd 2 O 3 -FI-PEG-BBN in PC-3 tumor cells. Moreover, Gd 2 O 3 -FI-PEG-BBN showed more remarkable contrast enhancement than the corresponding nontargeted Gd 2 O 3 -FI-PEG according to in vivo MRI and fluorescent imaging. Tumor immunohistochemical analysis further demonstrated improved accumulation of the targeted nanoprobe in tumors. BBN-conjugated Gd 2 O 3 may be a promising nanoplatform for simultaneous GRP receptor-targeted molecular cancer diagnosis and antitumor drug delivery in future clinical applications.

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Section: Materials and General Methodsmentioning

confidence: 99%

Section: Physicochemical Characterizationmentioning

confidence: 96%

mentioning

confidence: 99%

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Gastrin-releasing peptide receptor-targeted gadolinium oxide-based multifunctional nanoparticles for dual magnetic resonance/fluorescent molecular imaging of prostate cancer

Cui¹,

Lü²,

Yan³

et al. 2017

IJN

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“…The results showed that these UCN/UCL/MRI nanoparticles act as good MRI contrast agents and fluorescence nanoprobes for live cell imaging. The researchers utilized the luminescence-emission capability of the UCNs for the activation of a PS to achieve significant PDT results and image-guided delivery (Liu, Huang, et al, 2017). …”

Section: Anticancer Therapeutics and Nanoparticle-based Delivery Agentsmentioning

confidence: 99%

“…These HES-SS-PTX nanoparticles showed a prolonged half-life compared with that of the commercial PTX formulation (Taxol), resulting in more tumor accumulation. In reductive conditions, HES-SS-PTX NPs showed better therapeutic efficiency than did Taxol in in vitro and in vivo models in 4T1 tumor-bearing mice (Li, Hu, et al, 2017). In another approach, a mixed micelle system was developed with redox-sensitive mPEG-SS-PTX and mPEG-SS-DOX conjugates to reduce the side effects.…”

Section: Stimuli-responsive Drug Deliverymentioning

confidence: 99%

Recent Advances in Nanoparticle-Based Cancer Drug and Gene Delivery

Amreddy

Babu

Muralidharan

et al. 2018

Advances in Cancer Research

234

145

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Effective and safe delivery of anticancer agents is among the major challenges in cancer therapy. The majority of anticancer agents are toxic to normal cells, have poor bioavailability, and lack in vivo stability. Recent advancements in nanotechnology provide safe and efficient drug delivery systems for successful delivery of anticancer agents via nanoparticles. The physicochemical and functional properties of the nanoparticle vary for each of these anticancer agents, including chemotherapeutics, nucleic acid-based therapeutics, small molecule inhibitors, and photodynamic agents. The characteristics of the anticancer agents influence the design and development of nanoparticle carriers. This review focuses on strategies of nanoparticle-based drug delivery for various anticancer agents. Recent advancements in the field are also highlighted, with suitable examples from our own research efforts and from the literature.

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Synthesis of gold nanoparticles by pulsed laser-assisted reduction of aqueous gold precursor

2019

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Magnetic and fluorescent Gd<sub>2</sub>O<sub>3</sub>:Yb<sup>3+</sup>/Ln<sup>3+</sup> nanoparticles for simultaneous upconversion luminescence/MR dual modal imaging and NIR-induced photodynamic therapy

Cited by 39 publications

References 41 publications

Gastrin-releasing peptide receptor-targeted gadolinium oxide-based multifunctional nanoparticles for dual magnetic resonance/fluorescent molecular imaging of prostate cancer

Gastrin-releasing peptide receptor-targeted gadolinium oxide-based multifunctional nanoparticles for dual magnetic resonance/fluorescent molecular imaging of prostate cancer

Recent Advances in Nanoparticle-Based Cancer Drug and Gene Delivery

Synthesis of gold nanoparticles by pulsed laser-assisted reduction of aqueous gold precursor

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