Magnetic and Golden Yogurts. Food as a Potential Nanomedicine Carrier

Garcés, Víctor; González, Ana; Sabio, Laura; Sánchez-Arévalo, Carmen M.; Gálvez, Natividad; Domínguez‐Vera, José M.

doi:10.3390/ma13020481

Cited by 12 publications

(12 citation statements)

References 37 publications

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“…The oral iron supplement, including iron fortified formula milk, has been widely studied in infants and children. [ 47 ] In most conditions, the oral iron supplement has been shown to reduce anemia. [ 48 ] However, side effects of oral iron supplement have been reported such as diarrhea and intestinal inflammation under conditions of disease burden.…”

Section: Resultsmentioning

confidence: 99%

Mammary Leukocyte‐Assisted Nanoparticle Transport Enhances Targeted Milk Trace Mineral Delivery

et al. 2022

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Nanoparticles are applied as versatile platforms for drug/gene delivery in many applications owing to their long‐retention and specific targeting properties in living bodies. However, the delivery mechanism and the beneficial effect of nanoparticle‐retention in many organisms remain largely uncertain. Here, the transport and metabolism of mineral nanoparticles in mammary gland during lactation are explored. It is shown that maternal intravenous administration of iron oxide nanoparticles (IONPs; diameter: ≈11.0 nm, surface charge: −29.1 mV, surface area: 1.05 m2 g−1) provides elevated iron delivery to mammary gland and increased iron secretion into breast milk, which is inaccessible by classical iron‐ion transport approaches such as the transferrin receptor‐mediated endocytic pathway. Mammary macrophages and neutrophils are found to play dominant roles in uptake and delivery of IONPs through an unconventional leukocyte‐assisted iron secretion pathway. This pathway bypasses the tight iron concentration regulation of liver hepcidin‐ferroportin axis and mammary epithelial cells to increase milk iron‐ion content derived from IONPs. This work provides keen insight into the metabolic pathway of nanoparticles in mammary gland while offering a new scheme of nutrient delivery for neonate metabolism regulation by using nanosized nutrients.

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Section: Resultsmentioning

confidence: 99%

Mammary Leukocyte‐Assisted Nanoparticle Transport Enhances Targeted Milk Trace Mineral Delivery

et al. 2022

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Section: Methodsmentioning

confidence: 99%

“…AuNR-bacteria and AuNPR-bacteria were collected at 100g for 20 min and characterized by UV-vis spectroscopy (using a Thermo Spectronic Unicam UV 300 spectrophotometer), TEM, highangle annular dark-field scanning transmission electron microscopy (HAADF-STEM) and energy-dispersive X-ray spectroscopy (EDX) as previously reported. 35 2.8 Simultaneous grafting of MNP and AuNPR to the bacteria To incorporate both MNP and AuNPR onto the bacterial surface, 33.3 µL of 0.95 M MNP were mixed with 2 mL of AuNPR colloidal solution and stirred until the mixture was homogenized. A 10 mL aliquot of a Lf culture was collected and centrifugated at 3000g for 10 min.…”

Section: Grafting Gold Nanoparticles To the Bacteriamentioning

confidence: 99%

Magneto-optical hyperthermia agents based on probiotic bacteria loaded with magnetic and gold nanoparticles

et al. 2022

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“…The results indicated that magnetite nanoparticles proved to be an effective supplement in the treatment of iron deficiency anemia. 160 (iv) TiO 2titanium oxide components are used in the food industry as brightening substances. Animal studies indicated that titanium oxide nanoparticles accumulated in mammalian tissues.…”

Section: Food and Function Reviewmentioning

confidence: 99%