Magnetic and near-infrared-II fluorescence Au–Gd nanoclusters for imaging-guided sensitization of tumor radiotherapy

Abstract

The significant role of multifunctional nanoprobes with complementary advantages in magnetic and near-infrared-II (NIR-II, 1,000–1,700 nm) fluorescent properties have been documented in precision cancer theranostics. However, certain limitations, including the...

Nanotechnology-based diagnostics and therapeutics in acute lymphoblastic leukemia: a systematic review of preclinical studies

“…Due to their high surface-to-volume ratio, they can also transport many different chemicals and pharmaceuticals for delivery applications. 15,16,96,97…”

“…Due to their high surface-to-volume ratio, they can also transport many different chemicals and pharmaceuticals for delivery applications. 15,16,96,97 The construction, supercial area, mechanical rigidity, metallic properties, conductivity (both electrical and thermal), and ultra-light weight are some unique physical and chemical characteristics of CNTs. They display higher drug loading than standard liposomes and dendrimer drug carriers based on their large specic surface area.…”

Near‐Infrared Emission‐Cyanine 5.5 and Doxorubicin Loaded Magnetite Nanoparticles for Dual In Vivo Magnetic Resonance and Biodistribution Imaging

“…The crystalline structure of these fabricated NPs was investigated using Xray diffraction (XRD). From the patterns, Figure 7A shows that prominent peaks observed at 30.34°(220), 35.71°(311), 43.22°( 400), 53.65°(422), 57.24°(511), and 63.09°(440) are in good accordance with the inverse cubic spinel phase of Fe 3 O 4 (magnetite, JCPDS card no. 85-1436).…”

“…The synergetic combination of MRI and NIR fluorescence signals facilitated excellent in vivo imaging for understanding concealed microstructures or bioprocesses in biological objects [32,33] . This combination is especially promising in providing high sensitivity and structural information on lesions through fluorescence and MRI contrast enhancement effects in cancer diagnosis and treatment [34,35] . Thus, the combination of Cyanine 5.5, the near‐infrared fluorescent agent, and Fe 3 O 4 NPs, the T 2 ‐MRI agent, in the nano drug delivery system makes it interesting for NIR/MR dual‐modality imaging.…”

Polyoxometalate-based nanocomposites for antitumor and antibacterial applications

“…Cellular signaling molecules, such as metal ions, reactive oxygen species (ROS), and active nitrogen substances (RNS), are closely related to various physiological and pathological processes. 41,42 Therefore, the efficient detection of small cell molecules is of great signicance for disease diagnosis and human health management. Among them, the excessive production of hydrogen peroxide (H 2 O 2 ) in reactive oxygen species (ROS) is related to the generation of many inammatory diseases; thus, the detection of H 2 O 2 has become a research hotspot.…”