Magnetic bioactive glass nano-heterostructures: a deeper insight into magnetic hyperthermia properties in the scope of bone cancer treatment

Vergnaud, F.; Kesse, Xavier; Jacobs, A.; Perton, Francis; Mertz, Damien; Descamps, Stéphane; Vichery, C.; Nédélec, Jean-Marie

doi:10.1039/d2bm00319h

Cited by 7 publications

(4 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, the addition of Cu to the Fe-doped BGs enhanced their bioactivity, cytocompatibility, and antibacterial activity which is a critical parameter in tissue engineering approaches. Magnetic nanocomposites made of BGs and iron oxides have been previously reported as suitable compositions in magnetic hyperthermia and bone cancer treatment (Vergnaud et al, 2022). Recently, Borges et al fabricated superparamagnetic and highly bioactive nanocomposites by adding 10-30 wt% SPIONs to the sol-gel derived 58S BG (58SiO 2 -33CaO-9P 2 O 5 , wt%) and investigated their potential in magnetic hyperthermia (Borges, Ferreira, et al, 2022).…”

Section: Nbgs For Hyperthermiamentioning

confidence: 99%

“…For example, the potential effects of the size and shape of magnetic NBGs on their heat generation capacity are of utmost importance in this area of science. In addition, the combination method of SPIONs to BGs can affect the superparamagnetic properties of final products (Kesse et al, 2020; Vergnaud et al, 2022); for example, SPIONs embedded into/deposited onto the glasses has led to generating NBGs with different particle size and superparamagnetic features (Taşar & Ercan, 2023). Since physicochemical parameters (e.g., size and shape) of SPIONs can influence their magnetic properties (Choi et al, 2013; Kandasamy & Maity, 2015; Wortmann et al, 2014), BGs containing SPIONs may exhibit vary superparamagnetic characteristics in vitro and in vivo.…”

Section: Nbgs For Cancer Therapymentioning

confidence: 99%

See 1 more Smart Citation

Nanostructured bioactive glasses: A bird's eye view on cancer therapy

Kargozar

Moghanian

Rashvand

et al. 2023

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

Bioactive glasses (BGs) arewell known for their successful applications in tissue engineering and regenerative medicine. Recent experimental studies have shown their potential usability in oncology, either alone or in combination with other biocompatible materials, such as biopolymers. Direct contact with BG particles has been found to cause toxicity and death in specific cancer cells (bone‐derived neoplastic stromal cells) in vitro. Nanostructured BGs (NBGs) can be doped with anticancer elements, such as gallium, to enhance their toxic effects against tumor cells. However, the molecular mechanisms and intracellular targets for anticancer compositions of NBGs require further clarification. NBGs have been successfully evaluated for use in various well‐established cancer treatment strategies, including cancer hyperthermia, phototherapy, and anticancer drug delivery. Existing results indicate that NBGs not only enhance cancer cell death, but can also participate in the regeneration of lost healthy tissues. However, the application of NBGs in oncology is still in its early stages, and numerous unanswered questions must be addressed. For example, the impact of the composition, biodegradation, size, and morphology of NBGs on their anticancer efficacy should be defined for each type of cancer and treatment strategy. Moreover, it should be more clearly assessed whether NBGs can shrink tumors, slow/stop cancer progression, or cure cancer completely. In this regard, the use of computational studies (in silico methods) is highly recommended to design the most effective glass formulations for cancer therapy approaches and to predict, to some extent, the relevant properties, efficacy, and outcomes.This article is categorized under: Implantable Materials and Surgical Technologies > Nanomaterials and Implants Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

show abstract

Section: Nbgs For Hyperthermiamentioning

confidence: 99%

Section: Nbgs For Cancer Therapymentioning

confidence: 99%

Nanostructured bioactive glasses: A bird's eye view on cancer therapy

Kargozar

Moghanian

Rashvand

et al. 2023

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

show abstract

“…Frontiers in Bioengineering and Biotechnology frontiersin.org regulate bone metabolism in vitro and in vivo, and that they have favorable bone targeting, bone regeneration and biocompatibility properties. For instance, Zheng et al (2022) revealed that IONPs can alleviate osteoporosis induced by ovariectomized mice (OVX) by scavenging reactive oxygen species, promoting osteogenic differentiation of BMSCs and inhibiting osteoclastogenesis in vitro. Krzysztof et al (Marycz et al, 2022) combined aminopropyltriethoxysilane (APTES) modified nHAp with IO nanoparticles and demonstrated in vitro that this biomaterial promotes osteoblast viability and RUNX-2 expression, reduces osteoclast metabolism and inflammation, and can be used for healing of osteoporotic fractures.…”

Section: Figure 12mentioning

confidence: 99%

“… Sasikala et al (2022) developed a piezoelectric magnetic nanoparticle (PMNP) that can regulate cell behaviour and fate under ultrasound (US), magnetic field (MF) and light-responsive conditions to achieve superior bone regeneration and bone transformation after bone tumour surgery. Vergnaud et al (2022) designed superparamagnetic bioactive nanoparticles with an IO core (γ-Fe2O3) wrapped in a bioactive glass (SiO2-CaO) shell, which demonstrated in vitro experiments its non-toxic, bone healing and thermal therapeutic properties for direct or combined scaffolding of bone defects after bone tumour resection. It is apparent that IONPs have a great platform and opportunity in the treatment of pathological bone defects and have now gained great traction.…”

Section: Application Of Iron Oxide Nanoparticles In Pathological Bone...mentioning

confidence: 99%

Hope for bone regeneration: The versatility of iron oxide nanoparticles

Wang

Xie

et al. 2022

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Although bone tissue has the ability to heal itself, beyond a certain point, bone defects cannot rebuild themselves, and the challenge is how to promote bone tissue regeneration. Iron oxide nanoparticles (IONPs) are a magnetic material because of their excellent properties, which enable them to play an active role in bone regeneration. This paper reviews the application of IONPs in bone tissue regeneration in recent years, and outlines the mechanisms of IONPs in bone tissue regeneration in detail based on the physicochemical properties, structural characteristics and safety of IONPs. In addition, a bibliometric approach has been used to analyze the hot spots and trends in the field in order to identify future directions. The results demonstrate that IONPs are increasingly being investigated in bone regeneration, from the initial use as magnetic resonance imaging (MRI) contrast agents to later drug delivery vehicles, cell labeling, and now in combination with stem cells (SCs) composite scaffolds. In conclusion, based on the current research and development trends, it is more inclined to be used in bone tissue engineering, scaffolds, and composite scaffolds.

show abstract