Magnetic boron nitride nanosheets-based on pH-responsive smart nanocarriers for the delivery of doxorubicin for liver cancer treatment

Espinoza, Maria Janina Carrera; Lin, Kuen‐Song; Kunene, Sikhumbuzo Charles; Lin, Yousheng; Liu, Shin-Yun

doi:10.1016/j.colsurfb.2023.113129

Cited by 17 publications

(8 citation statements)

References 50 publications

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“…In vivo and in vitro analysis showed the inhibition of tumor growth, stimulated apoptosis in cancer cells, and enhanced the cytotoxic effects of DOX. [54] An ideal BN nanocarrier for cancer chemotherapy should not only possess long circulation life, efficient accumulation at the tumor site, and high cellular uptake but should also release the anticancer drug inside tumor cells in a controllable manner. [55] The drug release process can be controlled by internal stimuli (e.g., pH, [56] temperature, [57] redox condition, [58] enzymes [59] ) or external stimuli (e.g., magnetic field, [51] ultrasound, [60] X-ray, [61] light [62] ).…”

Section: Doxorubicin (Dox)mentioning

confidence: 99%

Hexagonal boron nitride nanomaterials for biomedical applications

Wang,

Long,

Deng

et al. 2024

BMEMat

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Hexagonal boron nitride (h‐BN) nanomaterials are a rising star in the field of biomedicine. This review presents an overview of the progress in h‐BN nanomaterials for biological applications. It begins with a general introduction of the structural characteristics of h‐BN, followed by the brief introduction of its physical and chemical properties, including thermal, band and mechanical properties, chemical reactivity, biodegradability and biocompatibility, then emphasizes on the recent progress in the biomedical applications including drug delivery, boron neutron capture therapy (BNCT), bioimaging and nanozyme, and ends with the challenges and perspectives related to the biomedical applications. The advantages of BN nanomaterials used for biomedical applications were analyzed, and their problems were also discussed, inspiring the future rational designs of the BN nanomedicines.

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Section: Doxorubicin (Dox)mentioning

confidence: 99%

Hexagonal boron nitride nanomaterials for biomedical applications

Wang,

Long,

Deng

et al. 2024

BMEMat

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“…In order for DDSs to be effective in targeted therapy, it is crucial to improve their biocompatibility and targeting ability. To improve biocompatibility, various materials such as biodegradable polymers [ 130 , 145 , 146 ], sugars [ 129 , 130 , 147 ], lipids [ 133 ], and proteins [ 148 , 149 ] have been used. These materials can be used for coating purposes to reduce the toxicity and immunogenicity of the resulting DDS.…”

Section: Chemotherapy Delivery Using Magnetic Nanoparticlesmentioning

confidence: 99%

“…Regarding their indication, DOX-containing DDSs were developed for a wide variety of cancers, including breast cancer [ 123 , 147 , 150 ], liver cancer [ 131 , 133 , 145 ], lung cancer [ 151 ], and colorectal carcinoma [ 129 , 132 , 152 ].…”

Section: Chemotherapy Delivery Using Magnetic Nanoparticlesmentioning

confidence: 99%

“…Thus, MNPs and boron nanosheets coated with a pH-responsive PEG polymer were used for the fabrication of a new DDS for which highly controlled loading and release processes were optimized for DOX. Both in vitro and in vivo experiments have demonstrated that the DDS can inhibit tumor growth, induce cancer cell apoptosis, and reduce the toxic effects of DOX, a potential alternative for liver cancer therapy [ 145 ]. Polysaccharides such as chitosan or its modified forms can also be employed for the functionalization of MNPs for DOX delivery.…”

Section: Chemotherapy Delivery Using Magnetic Nanoparticlesmentioning

confidence: 99%

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Recent Advances in the Development of Drug Delivery Applications of Magnetic Nanomaterials

et al. 2023

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With the predicted rise in the incidence of cancer, there is an ever-growing need for new cancer treatment strategies. Recently, magnetic nanoparticles have stood out as promising nanostructures for imaging and drug delivery systems as they possess unique properties. Moreover, magnetic nanomaterials functionalized with other compounds can lead to multicomponent nanoparticles with innovative structures and synergetic performance. The incorporation of chemotherapeutic drugs or RNA in magnetic drug delivery systems represents a promising alternative that can increase efficiency and reduce the side effects of anticancer therapy. This review presents a critical overview of the recent literature concerning the advancements in the field of magnetic nanoparticles used in drug delivery, with a focus on their classification, characteristics, synthesis and functionalization methods, limitations, and examples of magnetic drug delivery systems incorporating chemotherapeutics or RNA.

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“…The latter enables development of short-range attraction and subsequent adsorption of macromolecular-proteins on nanoparticles. The conditions in-vivo provide an ideal environment for opsonization of nanoparticles by van der Waals forces of attraction 33,34. The van der Waals forces are attractive forces generated by fluctuation in the dipole moments of molecules.…”

mentioning

confidence: 99%

Evasion of opsonization of macromolecules using novel surface‐modification and biological‐camouflage‐mediated techniques for next‐generation drug delivery

Mehta,

Shende

2023

Cell Biochemistry & Function

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Opsonization plays a pivotal role in hindering controlled drug release from nanoformulations due to macrophage‐mediated nanoparticle destruction. While first and second‐generation delivery systems, such as lipoplexes (50–150 nm) and quantum dots, hold immense potential in revolutionizing disease treatment through spatiotemporal controlled drug delivery, their therapeutic efficacy is restricted by the selective labeling of nanoparticles for uptake by reticuloendothelial system and mononuclear phagocyte system via various molecular forces, such as electrostatic, hydrophobic, and van der Waals bonds. This review article presents novel insights into surface‐modification techniques utilizing macromolecule‐mediated approaches, including PEGylation, di‐block copolymerization, and multi‐block polymerization. These techniques induce stealth properties by generating steric forces to repel micromolecular‐opsonins, such as fibrinogen, thereby mitigating opsonization effects. Moreover, advanced biological methods, like cellular hitchhiking and dysopsonic protein adsorption, are highlighted for their potential to induce biological camouflage by adsorbing onto the nanoparticulate surface, leading to immune escape. These significant findings pave the way for the development of long‐circulating next‐generation nanoplatforms capable of delivering superior therapy to patients. Future integration of artificial intelligence‐based algorithms, integrated with nanoparticle properties such as shape, size, and surface chemistry, can aid in elucidating nanoparticulate‐surface morphology and predicting interactions with the immune system, providing valuable insights into the probable path of opsonization.

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Magnetic boron nitride nanosheets-based on pH-responsive smart nanocarriers for the delivery of doxorubicin for liver cancer treatment

Cited by 17 publications

References 50 publications

Hexagonal boron nitride nanomaterials for biomedical applications

Hexagonal boron nitride nanomaterials for biomedical applications

Recent Advances in the Development of Drug Delivery Applications of Magnetic Nanomaterials

Evasion of opsonization of macromolecules using novel surface‐modification and biological‐camouflage‐mediated techniques for next‐generation drug delivery

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