Magnetic capture of superparamagnetic nanoparticles in a constant pressure microcapillary flow

Darton, Nicholas J.; Hallmark, Bart; James, T. A.; Agrawal, Pulkit; Mackley, M. R.; Slater, Nigel K.H.

doi:10.1016/j.jmmm.2009.02.088

Cited by 8 publications

(5 citation statements)

References 8 publications

(10 reference statements)

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“…[3,4] The number, position and size of the microcapillaries could be adjusted through changing the structure of the die mold and altering the process parameters. Since first reported, MCFs have been employed in various applications of DOI: 10.1002/mame.202100958 nanoparticle capture, [5][6][7] droplet generation, [8,9] micromixing, [10] chemical reaction, [11] heat collection, [12,13] and immunoassays. [14][15][16] Recently, Zhao et al successfully fabricated foamed MCFs which had a dual network of interconnected pores and internal channels by supercritical carbon dioxide foaming.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Precise Control of Microcapillary Size in Microcapillary Films by Liquid‐Assisted Extrusion

Liu

Zheng

et al. 2022

Macro Materials & Eng

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Microcapillary films (MCFs) are plastic films with an array of microcapillaries, which have been widely applied in microfluidics and bioanalytical techniques. However, the precise control of microcapillary size is still a problem hindering the industrial applications of MCFs because the high size uniformity of microcapillaries ensures the production of homogeneous droplets and the robust performance of immunoassays. Here, a novel approach is provided to precisely adjust the size of microcapillaries by liquid‐assisted extrusion and to investigate the combined effects of extrusion, drawing and liquid injection on the microcapillary size. Compared with gas‐assisted extrusion, the size uniformity is improved by at least 5% for 89% experiments and 10% for 42% experiments. Therefore, this method facilitates MCFs’ applications in droplet microfluidics and biotechnologies.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Precise Control of Microcapillary Size in Microcapillary Films by Liquid‐Assisted Extrusion

Liu

Zheng

et al. 2022

Macro Materials & Eng

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“…Microcapillary films (MCFs) are plastic films containing an array of parallel microcapillaries fabricated via a microextrusion process. First reported by Hallmark et al in 2005, [1] MCFs DOI: 10.1002/mame.202100499 have been employed in various applications such as microreactions, [2][3][4] micromixing, [5] droplet generation, [6] crystal generation, [7] nanoparticle capture, [8][9][10] and bioanalytical technologies. [11][12][13][14][15] Several kinds of polymers have been used to produce MCFs, including ethylene vinyl alcohol, [16] thermoplastic polyurethane, [5] polyethylene, [17] polylactic acid, [18] and fluorinated ethylene propylene.…”

Section: Introductionmentioning

confidence: 99%

Improved Size Uniformity of Microcapillaries in Microcapillary Films by Separate Gas Injection

Liu

Zhao

et al. 2021

Macro Materials & Eng

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Microcapillary films (MCFs) are microextrusion-processed plastic films containing an array of parallel microcapillaries, and have been widely utilized as microfluidic platforms. However, the nonuniform size distribution within a single MCF strip limits the application of MCFs in monodisperse droplet generation. In this paper, the mechanisms that lead to uneven microcapillary dimensions in conventional MCFs whose gas pressures in all channels are the same is first clarified. The effect of gas pressure in a single channel on the microcapillary dimensions in the film is then studied. Finally, the size uniformity of the microcapillaries is improved by separate gas injection in different channels, providing new possibilities for the generation of highly monodisperse microdroplets.

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“…In some cases, their internalization can strongly reduce the proliferation of cancer cells [8]. Particles in the 300-600 nm range can also be used for the embolization of tumor vasculature to necrotize tumor tissue [9].…”

Section: Introductionmentioning

confidence: 99%

Necrosis of HepG2 cancer cells induced by the vibration of magnetic particles

Wang

Bienvenu

Mendez-Garza

et al. 2013

Journal of Magnetism and Magnetic Materials

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International audienceExperiments of magnetolysis, i.e., destruction of cells induced with magnetic particles (MPs) submitted to the application of a magnetic field, were conducted on HepG2 cancer cells. We herein demonstrate the usefulness of combining anisotropic MPs with an alternative magnetic field in magnetolysis. Thus, the application of an alternative magnetic field of low frequency (a few Hertz) in the presence of anisotropic, submicronic particles allowed the destruction of cancer cells "in vitro". We also show that a constant magnetic field is far less efficient than an oscillating one. Moreover, we demonstrate that, at equal particle volume, it is much more efficient to utilize spindle shaped particles rather than spherical ones. In order to get deeper insight into the mechanism of magnetolysis experiments, we performed a study by AFM, which strongly supports that the magnetic field induces the formation of clusters of particles becoming then large enough todamage cell membranes

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Magnetic capture of superparamagnetic nanoparticles in a constant pressure microcapillary flow

Cited by 8 publications

References 8 publications

Precise Control of Microcapillary Size in Microcapillary Films by Liquid‐Assisted Extrusion

Precise Control of Microcapillary Size in Microcapillary Films by Liquid‐Assisted Extrusion

Improved Size Uniformity of Microcapillaries in Microcapillary Films by Separate Gas Injection

Necrosis of HepG2 cancer cells induced by the vibration of magnetic particles

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