Magnetic Characterization by Scanning Microscopy of Functionalized Iron Oxide Nanoparticles

Abstract

This study aimed to systematically understand the magnetic properties of magnetite (Fe3O4) nanoparticles functionalized with different Pluronic F-127 surfactant concentrations (Fe3O4@Pluronic F-127) obtained by using an improved magnetic characterization method based on three-dimensional magnetic maps generated by scanning magnetic microscopy. Additionally, these Fe3O4 and Fe3O4@Pluronic F-127 nanoparticles, as promising systems for biomedical applications, were prepared by a wet chemical reaction. The magnetization curve was obtained through these three-dimensional maps, confirming that both Fe3O4 and Fe3O4@Pluronic F-127 nanoparticles have a superparamagnetic behavior. The as-prepared samples, stored at approximately 20 °C, showed no change in the magnetization curve even months after their generation, resulting in no nanoparticles free from oxidation, as Raman measurements have confirmed. Furthermore, by applying this magnetic technique, it was possible to estimate that the nanoparticles’ magnetic core diameter was about 5 nm. Our results were confirmed by comparison with other techniques, namely as transmission electron microscopy imaging and diffraction together with Raman spectroscopy. Finally, these results, in addition to validating scanning magnetic microscopy, also highlight its potential for a detailed magnetic characterization of nanoparticles.

SI-ATRP Decoration of Magnetic Nanoparticles with PHEMA and Post-Polymerization Modification with Folic Acid for Tumor Cells’ Specific Targeting

“…First of all, as it can be observed from Figure 6 , the magnetization curve of the MNP sample presents a lack of hysteresis, denoting that the analyzed sample has a superparamagnetic behavior with a saturation magnetization of 72.86 emu/g, confirming the fact that the method used to synthesize MNP produced superparamagnetic nanoparticles. When the surfaces of MNPs were modified, the saturation magnetization values dropped to 69.60, 36.47, 11.97 and 13.40 emu/g, corresponding to MNP-I, MNP-P, MNP-P-FA1 and MNP-P-FA2 samples, respectively, and, also, their superparamagnetic behavior is preserved, since there is no coercivity or remanence [ 64 ].…”

Nanocomposite hydrogels in skin cancer medicine

“…Due to the hydrophobic nature of the iron core, IONPs are typically synthesized with various hydrophilic coatings (e.g., chitosan, PEG, dextran, heparin, pluronic, polyethylene imine, etc.) to ensure suspension stability [32][33][34][35][36]. The choice of coating material influences IONPs' properties, mostly cytotoxicity and pharmacokinetics.…”

An overview into advantages and applications of conventional and unconventional hydro(solvo)thermal approaches for novel advanced materials design

“…Current research has been moving towards the new configuration development of heterostructured materials with increasingly complex structures to maximize their properties. Thus, the heterostructured materials by definition are usually based on the combination of two or more components to form composite structures, which can also be classified into decorated (or open-shell), core-shell, yolk-shell and Janus-like structures according to their configurations exhibit superior physical properties [434][435][436][437][438][439][440][441][442][443][444][445][446][447][448].…”