Magnetic colloidal nanoformulations to remotely trigger mechanotransduction for osteogenic differentiation

Estévez, Manuel; Cicuéndez, Mónica; Colilla, Montserrat; Vallet-Regí, María; González, Blanca; Izquierdo-Barba, Isabel

doi:10.1016/j.jcis.2024.03.043

Cited by 1 publication

(1 citation statement)

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“…On the other hand, Runx2 has already been evaluated as a biomarker of bone regeneration in novel biomechanical approaches. In cases of bone loss, a new method encompassing targeted magnetic stimulus evokes mechanotransduction and the induction of Runx2 and alkaline phosphatase to foster osteogenic differentiation with a drug-free process [98]. An additional magnetic nanoparticle (MNP)-based platform can remotely apply mechanical stimulus to bind to integrin-α5 and upregulate Runx2 and lymphoid enhancer-binding factor 1 (LEF1).…”

Section: Therapeutic Opportunitiesmentioning

confidence: 99%

Runx2 and Polycystins in Bone Mechanotransduction: Challenges for Therapeutic Opportunities

Gargalionis,

Adamopoulos,

Vottis

et al. 2024

IJMS

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Bone mechanotransduction is a critical process during skeletal development in embryogenesis and organogenesis. At the same time, the type and level of mechanical loading regulates bone remodeling throughout the adult life. The aberrant mechanosensing of bone cells has been implicated in the development and progression of bone loss disorders, but also in the bone-specific aspect of other clinical entities, such as the tumorigenesis of solid organs. Novel treatment options have come into sight that exploit the mechanosensitivity of osteoblasts, osteocytes, and chondrocytes to achieve efficient bone regeneration. In this regard, runt-related transcription factor 2 (Runx2) has emerged as a chief skeletal-specific molecule of differentiation, which is prominent to induction by mechanical stimuli. Polycystins represent a family of mechanosensitive proteins that interact with Runx2 in mechano-induced signaling cascades and foster the regulation of alternative effectors of mechanotransuction. In the present narrative review, we employed a PubMed search to extract the literature concerning Runx2, polycystins, and their association from 2000 to March 2024. The keywords stated below were used for the article search. We discuss recent advances regarding the implication of Runx2 and polycystins in bone remodeling and regeneration and elaborate on the targeting strategies that may potentially be applied for the treatment of patients with bone loss diseases.

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Section: Therapeutic Opportunitiesmentioning

confidence: 99%