Magnetic composite scaffolds of polycaprolactone/nFeHA, for bone-tissue engineering

Dı́az, Esperanza; Valle, María Blanca; Barandiarán, J.M.

doi:10.1080/00914037.2016.1149848

Cited by 8 publications

(8 citation statements)

References 14 publications

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“…As from week 5, it drastically increased up until week 25, especially for the composition with 10% nanoparticles. This behavior was very different from the one presented by the PCL-nHAFe system [22], which underwent rapid and greater absorption from week 5.…”

Section: Resultscontrasting

confidence: 71%

“…Therefore, magnetic nanoparticles and scaffolds are promising alternatives for bone regeneration. The magnetic fields of the scaffolds function by attracting and absorbing stem cells, in vivo growth factors, and other bioactive agents tied to magnetic particles, favoring bone regeneration and repair [17,18,19,20,21,22,23].…”

Section: Introductionmentioning

confidence: 99%

“…There are two methods for the manufacture of magnetic scaffolds: one consists of submerging a scaffold in water-based ferrofluids that contain IONPs through capillary adsorption, as described by other authors [6,19]. The other method involves the incorporation of IONPs during scaffold preparation, a method that requires effective ultrasonic nanoparticle dispersion, to prevent agglomeration [20,21,22,23,24,25,26,27].…”

Section: Introductionmentioning

confidence: 99%

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3D Cytocompatible Composites of PCL/Magnetite

et al. 2019

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A study of Magnetite (Fe3O4) as a suitable matrix for the improved adhesion and proliferation of MC3T3-E1 pre-osteoblast cells in bone regeneration is presented. Biodegradable and magnetic polycaprolactone (PCL)/magnetite (Fe3O4) scaffolds, which were fabricated by Thermally Induced Phase Separation, are likewise analyzed. Various techniques are used to investigate in vitro degradation at 37 °C, over 104 weeks, in a phosphate buffered saline (PBS) solution. Magnetic measurements that were performed at physiological temperature (310 K) indicated that degradation neither modified the nature nor the distribution of the magnetite nanoparticles. The coercive field strength of the porous matrices demonstrated ferromagnetic behavior and the probable presence of particle interactions. The added nanoparticles facilitated the absorption of PBS, with no considerable increase in matrix degradation rates, as shown by the Gel Permeation Chromatography (GPC) results for Mw, Mn, and I. There was no collapse of the scaffold structures that maintained their structural integrity. Their suitability for bone regeneration was also supported by the absence of matrix cytotoxicity in assays, even after additions of up to 20% magnetite.

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Section: Resultscontrasting

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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3D Cytocompatible Composites of PCL/Magnetite

et al. 2019

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“…∆H c , ∆H m , and Xc% decreased with degradation time, although some samples (10 wt % FeHA and 30 wt % FeHA) slightly increased crystallinity around the 12th week of degradation. This increase, discussed in the literature [ 15 , 23 , 24 , 25 , 26 , 27 ], is attributed to the splitting of the chains, which as they shorten, reorder more easily and form crystals.…”

Section: Resultsmentioning

confidence: 98%

“…The protocol for the synthesis of the PLLA/FeHA composite scaffolds previously described in [ 15 ] was followed. In short, a PLLA solution was prepared in 1,4 dioxane (2.5% ( w/v )).…”

Section: Methodsmentioning

confidence: 99%

Development of Magnetically Active Scaffolds for Bone Regeneration

et al. 2018

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This work reports on the synthesis, with the thermally induced phase separation (TIPS) technique, of poly (l-lactide) (PLLA) scaffolds containing Fe-doped hydroxyapatite (FeHA) particles for bone regeneration. Magnetization curves and X-ray diffraction indicate two magnetic particle phases: FeHA and magnetite Fe3O4. Magnetic nanoparticles (MNPs) are approximately 30 ± 5 nm in width and 125 ± 25 nm in length, and show typical ferromagnetic properties, including coercivity and rapid saturation magnetization. Scanning electron microscopy (SEM) images of the magnetic scaffolds reveal their complex morphology changes with MNP concentration. Similarly, at compositions of approximately 20% MNPs, the phase separation changes, passing from solid–liquid to liquid–liquid as revealed by the hill-like structures, with low peaks that give the walls in the SEM images a surface pattern of micro-ruggedness typical of nucleation mechanisms and growth. In vitro degradation experiments, carried out for more than 28 weeks, demonstrated that the MNPs delay the scaffold degradation process. Cytotoxicity is appreciated for FeHA content above 20%.

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Adaptive Materials Based on Iron Oxide Nanoparticles for Bone Regeneration

et al. 2018

ChemPhysChem

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The paper provides a brief overview of the use of iron oxide nanoparticles (IONPs) in the areas of bone regenerative medicine. Reconstruction of bone defects caused by trauma, non-union, and bone tumor excision, still faces many challenges despite the intense investigations and advancement in bone-tissue engineering and bone regeneration over the past decades. IONPs have promising prospects in this field due to their controlled responsive characteristics in specific external magnetic fields and have been of great interest during the last few years. This Minireview aims to summarize the relevant progress and describes the following five aspects: (i) The general introduction of IONPs, with a focus on the magnetic properties as the base of application; (ii) using IONPs as tools to study and control stem cells for better treatment efficacy in stem-cell-based bone defect repair; (iii) the use of IONPs and their complexes in the delivery of therapeutic agents, including chemical drug molecules, growth factors, and genetic materials, to promote osteogenesis-related cell function and differentiation, healthy bone tissue growth, and functional reconstruction; (iv) magneto-mechanical actuation in the regulation of cells distribution, mechano-transduction membrane receptors activation, and mechanosensitive signaling pathways regulation, and (v) fabrication, characteristics, and in vitro and in vivo osteogenic effects of magnetic composite bone scaffolds. Ongoing prospects are also discussed.

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Magnetic composite scaffolds of polycaprolactone/nFeHA, for bone-tissue engineering

Cited by 8 publications

References 14 publications

3D Cytocompatible Composites of PCL/Magnetite

3D Cytocompatible Composites of PCL/Magnetite

Development of Magnetically Active Scaffolds for Bone Regeneration

Adaptive Materials Based on Iron Oxide Nanoparticles for Bone Regeneration

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