Magnetic Compression Technique for Esophageal Anastomosis in Rats

Zhang, Miaomiao; Shi, Aihua; Liu, Peinan; Ye, Dan; Zhang, Hanzhi; Mou, Xingyi; Xu, Shuqin; Zhang, Zhixuan; Lyu, Yi; Yan, Xiaopeng

doi:10.1016/j.jss.2022.03.001

“…In previous studies, we have completed a large number of experimental studies and clinical applications of magnamosis in the digestive system 27 , 28 . Based on the satisfactory results conducted from these studies, we first proposed using MCT for ureterovesical anastomosis in the treatment of ureteral stricture/atresia.…”

Section: Discussionmentioning

confidence: 99%

An experimental study of magnetic compression technique for ureterovesical anastomosis in rabbits

An

¹

,

Zhang

²

,

Xu

³

et al. 2023

Sci Rep

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This study aimed to explore the feasibility of the magnetic compression technique (MCT) for ureterovesical anastomosis in a rabbit model with ureteral obstruction. The distal ureteral obstruction model using female New Zealand rabbits was induced by ligating the distal end of the right ureter with silk thread for four weeks. A pair of cylindrical NdFeB magnets (daughter magnet and parent magnet) with a hole in the center was used for the ureterovesical anastomosis. The daughter magnet and the parent magnet were respectively placed close to the obstruction site through the dilated proximal ureter and urethra, and then the daughter-parent magnets pair was attracted together automatically. Postoperative X-rays were taken to confirm the position of the magnets. The anastomotic stoma specimens were obtained two weeks postoperatively, and the anastomotic stoma formation was observed by the naked eye and histological staining. The operation time and the anastomotic burst pressure were measured. The ureter was significantly dilated in the fourth week after ligation, which satisfied the placement of the daughter magnet. The ureterovesical magnet placements were successfully performed in ten experimental rabbits, with an operation time of 36.5 ± 6.09 min. The parent and daughter magnets attracted each other well and were subsequently removed through the urethra two weeks postoperatively, resulting in the establishment of ureterovesical anastomosis. The anastomotic burst pressure was 147.5 ± 14.59 mmHg. Gross specimens and histological examination of the anastomotic stoma showed that the anastomotic stoma healed well. MCT is feasible and simple for ureterovesical anastomosis.

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“…In previous studies, we have completed a large number of experimental studies and clinical applications of magnamosis in the digestive system 27,28 . Based on the satisfactory results conducted from these studies, we rst proposed using MCT for ureterovesical anastomosis in the treatment of ureteral stricture/atresia.…”

Section: Discussionmentioning

confidence: 99%

Magnetic compression technique for ureterovesical anastomosis: An experimental study in rabbits

An

¹

,

Zhang

²

,

Xu

³

et al. 2022

Preprint

Self Cite

0

View full text Add to dashboard Cite

This study aimed to explore the feasibility of the magnetic compression technique (MCT) for ureterovesical anastomosis in a rabbit model with ureteral obstruction. The distal ureteral obstruction model using female New Zealand rabbits was induced by ligating the distal end of the right ureter with silk thread for four weeks. A pair of cylindrical NdFeB magnets (daughter magnet and parent magnet) with a hole in the center was used for the ureterovesical anastomosis. The daughter magnet and the parent magnet were respectively placed close to the obstruction site through the dilated proximal ureter and urethra, and then the daughter-parent magnets pair was attracted together automatically. Postoperative X-rays were taken to confirm the position of the magnets. The anastomotic stoma specimens were obtained two weeks postoperatively, and the anastomotic stoma formation was observed by the naked eye and histological staining. The operation time and the anastomotic burst pressure were measured. The ureter was significantly dilated in the fourth week after ligation, which satisfied the placement of the daughter magnet. The ureterovesical magnet placements were successfully performed in ten experimental rabbits, with an operation time of 36.5 ± 6.09 min. The parent and daughter magnets attracted each other well and were subsequently removed through the urethra two weeks postoperatively, resulting in the establishment of ureterovesical anastomosis. The anastomotic burst pressure was 147.5 ± 14.59 mmHg. Gross specimens and histological examination of the anastomotic stoma showed that the anastomotic stoma healed well. MCT is feasible and simple for ureterovesical anastomosis.

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“…The underlying principle of MCA is that the compressed tissue between two magnets undergoes ischemia, necrosis, and shedding, whereas the adjacent tissue undergoes adhesion, repair, and healing 10 . Presently, the application of MCA in the digestive tract includes esophageal anastomosis 11 , gastrointestinal anastomosis 12 , cholangiojejunostomy 13 , intestinal anastomosis 14 , and colonic anastomosis 15 . These findings from these investigations have established that MCA of the digestive tract is safe and reliable.…”

Section: Introductionmentioning

confidence: 99%

Feasibility experiment of a novel deformable self-assembled magnetic anastomosis ring (DSAMAR) for gastrointestinal anastomosis through a natural orifice

Zhang,

Zhong,

Ma

et al. 2024

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Although the application of magnetic compression anastomosis is becoming increasingly widespread, the magnets used in earlier studies were mostly in the shape of a whole ring. Hence, a deformable self-assembled magnetic anastomosis ring (DSAMAR) was designed in this study for gastrointestinal anastomosis. Furthermore, its feasibility was studied using a beagle model. The designed DSAMAR comprised 10 trapezoidal magnetic units. Twelve beagles were used as animal models, and DSAMARs were inserted into the stomach and colon through the mouth and anus, respectively, via endoscopy to achieve gastrocolic magnamosis. Surgical time, number of failed deformations, survival rate of the animals, and the time of magnet discharge were documented. A month later, specimens of the anastomosis were obtained and observed with the naked eye as well as microscopically. In the gastrocolic anastomosis of the 12 beagles, the procedure took 65–120 min. Although a deformation failure occurred during the operation in one of the beagles, it was successful after repositioning. The anastomosis was formed after the magnet fell off 12–18 days after the operation. Naked eye and microscopic observations revealed that the anastomotic specimens obtained 1 month later were well-formed, smooth, and flat. DSAMAR is thus feasible for gastrointestinal anastomosis under full endoscopy via the natural orifice.

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Magnetic Compression Technique for Esophageal Anastomosis in Rats

Cited by 11 publications

References 31 publications

An experimental study of magnetic compression technique for ureterovesical anastomosis in rabbits

An experimental study of magnetic compression technique for ureterovesical anastomosis in rabbits

Magnetic compression technique for ureterovesical anastomosis: An experimental study in rabbits

Feasibility experiment of a novel deformable self-assembled magnetic anastomosis ring (DSAMAR) for gastrointestinal anastomosis through a natural orifice

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