Magnetic delivery of antitumor carboplatin by using PEGylated-Niosomes

Abstract

To improve the efficiency of niosomal drug delivery, here we employed two tactics. First, niosomes were magnetized using FeO@SiO mangnetic nanoparticles, and second, their surface was modified by PEGylation. PEGylation was intended for increasing the bioavailability of niosomes, and magnetization was used for rendering them capable of targeting specific tissues. These PEGylated magnetic niosomes were also loaded with Carboplatin, an antitumor drug. Next, these niosomes were studied in terms of size, morphology, zeta potential, and drug entrapment efficiency. Then, the in vitro drug release from these modified niosomes was compared to that of both naked and nonmagnetized niosomes. Interestingly, although loading of naked-niosomes with magnetic particles lead to an increase in the rate of drug release, PEGylation of these magnetized niosomes caused a more sustained drug release. Thus, PEGylation of magnetic niosomes, besides improving their bioavailability, caused a slower and sustained release of the drug over time. Finally, studying the in vitro effectives of niosomal formulations towards MCF-7, a breast cancer cell line, showed that PEGylated magnetic niosomes had a satisfactory toxicity towards these cells in the presence of an external magnetic field. In conclusion, PEGylated magnetic niosomes showed enhanced qualities regarding the controlled release and delivery of drug. Graphical abstract ᅟ.

Plant-Based Gums and Mucilages Applications in Pharmacology and Nanomedicine: A Review

“…Natural and synthetic nanoparticles, such as liposomes, nanoparticles, and micelles, improve the stability and bioavailability, as well as the biological distribution of natural products. Nanosystems are able to deliver drugs to specific areas, so they can increase local drug concentrations and significantly reduce the adverse effects of drug uptake [ 25 , 26 , 27 , 28 , 29 , 30 ]. Therefore, natural nanoformulations have attracted a lot of attention [ 11 , 31 ].…”

In vitro cytotoxicity assay of D-limonene niosomes: an efficient nano-carrier for enhancing solubility of plant-extracted agents

“…Because of the nonionic nature of surfactants, niosomes have very low toxicity. In drug delivery approaches, biocompatibility and controlled release of the constituents play a great role in the treatment outcomes (2223). Though, niosomes have many advantages, little researches have been conducted for the delivery of phytochemicals using niosome nanocarriers (24).…”

Lipid-Based Nanoparticles: Application and Recent Advances in Cancer Treatment

“…On the other hand, niosomes have become one of the most interesting LBNPs in BreC treatment, which has led to the development of various systems to facilitate the vehiculization of gingerol [106], tamoxifen citrate (TXC) [107,108], carboplatin [109], silibinin [110,111], lawsone [112], mitoxantrone [113] or TQ [114]. Accordingly, Shaker et al [108] synthesized a TXC-niosome capable of increasing drug uptake in MCF-7 cells and reducing tumor volume in Ehrlich carcinoma model in vivo.…”