Magnetic Drug Targeting: A Novel Treatment for Intramedullary Spinal Cord Tumors

Kheirkhah, Pouyan; Denyer, Steven; Bhimani, Abhiraj D.; Arnone, Gregory D.; Esfahani, Darian R.; Aguilar, Tania; Zakrzewski, Jack; Venugopal, Indu; Habib, Nazia; Gallia, Gary L.; Linninger, Andreas A.; Charbel, Fady T.; Mehta, Ankit I.

doi:10.1038/s41598-018-29736-5

Cited by 71 publications

(56 citation statements)

References 40 publications

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“…Indeed, these features make up the physical identity of IONPs, understood as the physical properties intrinsic to the metallic core ( Table 1 and Figure 1 ). Physical identity ultimately determines the biomedical application of metallic nanoparticles in imaging/therapy, and the magnetic properties of IONPs make it possible for them to be used in MRI [ 5 ], magnetic targeting [ 6 , 7 , 8 ] and delivery [ 9 , 10 ], and hyperthermia [ 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

The Intrinsic Biological Identities of Iron Oxide Nanoparticles and Their Coatings: Unexplored Territory for Combinatorial Therapies

2020

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Over the last 20 years, iron oxide nanoparticles (IONPs) have been the subject of increasing investigation due to their potential use as theranostic agents. Their unique physical properties (physical identity), ample possibilities for surface modifications (synthetic identity), and the complex dynamics of their interaction with biological systems (biological identity) make IONPs a unique and fruitful resource for developing magnetic field-based therapeutic and diagnostic approaches to the treatment of diseases such as cancer. Like all nanomaterials, IONPs also interact with different cell types in vivo, a characteristic that ultimately determines their activity over the short and long term. Cells of the mononuclear phagocytic system (macrophages), dendritic cells (DCs), and endothelial cells (ECs) are engaged in the bulk of IONP encounters in the organism, and also determine IONP biodistribution. Therefore, the biological effects that IONPs trigger in these cells (biological identity) are of utmost importance to better understand and refine the efficacy of IONP-based theranostics. In the present review, which is focused on anti-cancer therapy, we discuss recent findings on the biological identities of IONPs, particularly as concerns their interactions with myeloid, endothelial, and tumor cells. Furthermore, we thoroughly discuss current understandings of the basic molecular mechanisms and complex interactions that govern IONP biological identity, and how these traits could be used as a stepping stone for future research.

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Section: Introductionmentioning

confidence: 99%

The Intrinsic Biological Identities of Iron Oxide Nanoparticles and Their Coatings: Unexplored Territory for Combinatorial Therapies

2020

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“…Indeed, magnetic drug delivery could enable a better treatment efficiency, while minimizing side effects of the chemotherapy. By functionalizing drug nanocarriers with therapeutic molecules able to interact specifically with tumor cells, it is possible to deliver drugs exclusively to the tumor tissue [27]. Another important application is targeted regenerative medicine and, more specifically, magnetically driven stem cells.…”

Section: Discussionmentioning

confidence: 99%

Pushing of Magnetic Microdroplet Using Electromagnetic Actuation System

et al. 2020

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Treatment of certain diseases requires the administration of drugs at specific areas of tissues and/or organs to increase therapy effectiveness and avoid side effects that may harm the rest of the body. Drug targeting is a research field that uses various techniques to administrate therapies at specific areas of the body, including magnetic systems able to drive nano “vehicles”, as well as magnetically labeled molecules, in human body fluids and tissues. Most available actuation systems can only attract magnetic elements in a relatively small workspace, limiting drug target applications to superficial tissues, and leaving no alternative cases where deep targeting is necessary. In this paper, we propose an electromagnetic actuation system able to push and deflect magnetic particles at distance of ~10 cm, enabling the manipulation of magnetic nano- and microparticles, as well as administration of drugs in tissues, which are not eligible for localized drug targeting with state-of-the-art systems. Laboratory experiments and modeling were conducted to prove the effectiveness of the proposed system. By further implementing our device, areas of the human body that previously were impossible to treat with magnetically labeled materials such as drugs, cells, and small molecules can now be accessible using the described system.

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“…Recently, Kheirkhah et al used a novel magnetic drug targeting technique (MDT) for the targeted in vivo delivery of DOX to high-grade intramedullary spinal cord tumor in immunodeficient athymic nude Crl:NIH- Foxn1 rnu rats. SPIONs carried DOX successfully localized to tumor sites demonstrating proof-of-concept that MDT may prove an effective and concentrated delivery system without toxicity for systemic administration [ 84 ]. In separate work, Foglia et al synthesized biocompatible ultrafine 3 nm water dispersible silica capped SPIONs by employing one-pot approach.…”

Section: Inorganic Nddps Implicated In Anti-cancer Therapymentioning

confidence: 99%

Advances in Therapeutic Implications of Inorganic Drug Delivery Nano-Platforms for Cancer

Naz

Shamoon

Wang

et al. 2019

IJMS

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Numerous nanoparticles drug delivery systems for therapeutic implications in cancer treatment are in preclinical development as conventional chemotherapy has several drawbacks. A chemotherapeutic approach requires high doses of chemotherapeutic agents with low bioavailability, non-specific targeting, and above all, development of multiple drug resistance. In recent years, inorganic nano-drug delivery platforms (NDDPs; with a metal core) have emerged as potential chemotherapeutic systems in oncology. One of the major goals of developing inorganic NDDPs is to effectively address the targeted anti-cancer drug(s) delivery related problems by carrying the therapeutic agents to desired tumors sites. In this current review, we delve into summarizing the recent developments in targeted release of anti-cancer drugs loaded in inorganic NDDPs such as mesoporous silica nanoparticles, carbon nanotubes, layered double hydroxides, superparamagnetic iron oxide nanoparticles and calcium phosphate nanoparticles together with highlighting their therapeutic performance at tumor sites.

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Magnetic Drug Targeting: A Novel Treatment for Intramedullary Spinal Cord Tumors

Cited by 71 publications

References 40 publications

The Intrinsic Biological Identities of Iron Oxide Nanoparticles and Their Coatings: Unexplored Territory for Combinatorial Therapies

The Intrinsic Biological Identities of Iron Oxide Nanoparticles and Their Coatings: Unexplored Territory for Combinatorial Therapies

Pushing of Magnetic Microdroplet Using Electromagnetic Actuation System

Advances in Therapeutic Implications of Inorganic Drug Delivery Nano-Platforms for Cancer

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