We analyze the thermoelectric response in layered metals with spontaneously broken rotation symmetry. We identify the anisotropy of the quasiparticle Nernst signal as an extremely sensitive probe of Fermi surface distortions characteristic of the ordered state. This is due to a subtle interplay of different transport anisotropies which become additionally enhanced near van-Hove singularities. Applied to recent experiments, our results reinforce the proposal that the underdoped cuprate superconductor YBa2Cu3O 6+δ displays such "electron-nematic" order in the pseudogap regime.Spontaneous breaking of lattice rotation symmetry due to electronic correlations is currently in the focus of intense interest, most prominently in cuprate hightemperature superconductors such as YBa 2 Cu 3 O 6+δ (Refs. 1-3) and in the metamagnetic metal Sr 3 Ru 2 O 7 (Ref. 4). In analogy to liquid crystals, a phase with broken rotation (but preserved translation) symmetry has been dubbed electron nematic. 5In cuprates, electron-nematic order has been discussed early on as intermediate phase which occurs upon melting of a uni-directional charge-density-wave ("stripe") phase. 5-7 Microscopically, it is one of the known instabilities of the two-dimensional (2d) Hubbard model. [8][9][10] The first clear-cut signature of electron-nematic order in cuprates was found in neutron scattering experiments on YBa 2 Cu 3 O 6.45 , 1 where the spin-fluctuation spectrum was found to develop a distinct anisotropic incommensurability below a temperature T of about 150 K. Earlier transport measurements on YBa 2 Cu 3 O 6+δ (Ref. 11) also detected resistivity anisotropies ρ a /ρ b of order 2 in the underdoped regime, but remained less conclusive. The reason is that the crystal structure of YBa 2 Cu 3 O 6+δ contains CuO chains which break the otherwise tetragonal symmetry of the CuO 2 planes. In an orderparameter language, this implies a small field which couples linearly to the nematic order parameter. This has two main effects: (i) potentially existing nematic order will be aligned and (ii) a nematic ordering transition will be smeared out. While (i) enables observables to show a macroscopic anisotropy, which might otherwise be masked by domain formation, (ii) implies that electronic nematic order and purely structural effects cannot be sharply distinguished. Remarkably, locally broken rotation symmetry has been found on the surface of Bi 2 Sr 2 CaCu 2 O 8+δ and Ca 2−x Na x CuO 2 Cl 2 using scanning tunneling microscopy. 12 In Sr 3 Ru 2 O 7 , nematic order is a candidate explanation for the low-T phase which masks the metamagnetic critical endpoint at around 8 T. 4,13 Resistivity anisotropies have been detected here, but a full picture has not yet emerged, because the rather unusual thermodynamics near the low-T phase boundaries is not understood.Very recent measurements 2,3 of the Nernst effect, 14 that is the transverse voltage induced by a thermal gradient in the presence of a magnetic field, have uncovered a surprisingly large anisotropy in YBa 2 Cu 3 O 6+δ ...