Magnetic field-assisted selective delivery of doxorubicin to cancer cells using magnetoliposomes as drug nanocarriers

Szuplewska, Aleksandra; Rękorajska, Aleksandra; Pocztańska, Edyta; Krysiński, Paweł; Dybko, Artur; Chudy, M.

doi:10.1088/1361-6528/ab19d3

Cited by 31 publications

(18 citation statements)

References 39 publications

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“…The magnetic properties of hydrophobic IONPs encapsulated exclusively in the lipid bilayer of liposomes were used to release Dox from the MLs. Further, the cell viability results demonstrated that the developed formulation was biocompatible and effective for the treatment of breast cancer [54] . In another study, methotrexate (MTX) loaded thermosensitive MLs were prepared for the target delivery to cervical cancer.…”

Section: Biomedical Application Of Hp-mnpsmentioning

confidence: 90%

Aspects of high-performance and bio-acceptable magnetic nanoparticles for biomedical application

Kush

Kumar

Singh

et al. 2021

Asian Journal of Pharmaceutical Sciences

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This review covers extensively the synthesis & surface modification, characterization, and application of magnetic nanoparticles. For biomedical applications, consideration should be given to factors such as design strategies, the synthesis process, coating, and surface passivation. The synthesis method regulates post-synthetic change and specific applications in vitro and in vivo imaging/diagnosis and pharmacotherapy/administration. Special insights have been provided on biodistribution, pharmacokinetics, and toxicity in a living system, which is imperative for their wider application in biology. These nanoparticles can be decorated with multiple contrast agents and thus can also be used as a probe for multi-mode imaging or double/triple imaging, for example, MRI-CT, MRI-PET. Similarly loading with different drug molecules/dye/fluorescent molecules and integration with other carriers have found application not only in locating these particles in vivo but simultaneously target drug delivery/hyperthermia inside the body. Studies are underway to collect the potential of these magnetically driven nanoparticles in various scientific fields such as particle interaction, heat conduction, imaging, and magnetism. Surely, this comprehensive data will help in the further development of advanced techniques for theranostics based on high-performance magnetic nanoparticles and will lead this research area in a new sustainable direction.

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Section: Biomedical Application Of Hp-mnpsmentioning

confidence: 90%

Aspects of high-performance and bio-acceptable magnetic nanoparticles for biomedical application

Kush

Kumar

Singh

et al. 2021

Asian Journal of Pharmaceutical Sciences

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“…The design of nanosystems based on iron oxide NBMs for controlled drug release is another promising area that is being intensively pursued using different approaches, such as drug encapsulation in the polymeric coating layer (Khaledian et al, 2020;Tsai et al, 2020), or by drug co-encapsulation in micelles (Bai et al, 2018;Manigandan et al, 2018), hydrogels (Indulekha et al, 2017;Zou et al, 2020), liposomes (Jose et al, 2019;Szuplewska et al, 2019), lipid NPs (Świętek et al, 2020), polymeric NPs (Mosafer et al, 2017;Luque-Michel et al, 2021), and mesoporous silica nanostructures (Asghar et al, 2020). The stimulated release is a very interesting strategy since it allows a better control on the delivery, ensuring the medicine will be released in the desired site and the therapeutic dose will be achieved (Santhosh and Ulrih, 2013;Monnier et al, 2014).…”

Section: Nanobiomaterials Based On Iron Oxide Nanoparticlesmentioning

confidence: 99%

Titanium and Iron Oxide Nanoparticles for Cancer Therapy: Surface Chemistry and Biological Implications

Kawassaki

Romano

Dietrich

et al. 2021

Front. Nanotechnol.

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Currently, cancer is among the most challenging diseases due to its ability to continuously evolve into a more complex muldimentional system, in addition to its high capability to spread to other organs and tissues. In this context, the relevance of nanobiomaterials (NBMs) for the development of new more effective and less harmful treatments is increasing. NBMs provide the possibility of combining several functionalities on a single system, expectedly in a synergic way, to better perform the treatment and cure. However, the control of properties such as colloidal stability, circulation time, pharmacokinetics, and biodistribution, assuring the concentration in specific target tissues and organs, while keeping all desired properties, tends to be dependent on subtle changes in surface chemistry. Hence, the behavior of such materials in different media/environments is of uttermost relevance and concern since it can compromise their efficiency and safety on application. Given the bright perspectives, many efforts have been focused on the development of nanomaterials fulfilling the requirements for real application. These include robust and reproducible preparation methods to avoid aggregation while preserving the interaction properties. The possible impact of nanomaterials in different forms of diagnosis and therapy has been demonstrated in the past few years, given the perspectives on how revolutionary they can be in medicine and health. Considering the high biocompatibility and suitability, this review is focused on titanium dioxide– and iron oxide–based nanoagents highlighting the current trends and main advancements in the research for cancer therapies. The effects of phenomena, such as aggregation and agglomeration, the formation of the corona layer, and how they can compromise relevant properties of nanomaterials and their potential applicability, are also addressed. In short, this review summarizes the current understanding and perspectives on such smart nanobiomaterials for diagnostics, treatment, and theranostics of diseases.

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“…Therefore, chemically functionalized maghemite ( γ -Fe 2 O 3 ) is used as an alternative in drug delivery systems targeting tumor cells via material surface modifications [34]. Recently, iron oxides have been conjugated with liposomes to create magnetoliposomes that are able to deliver chemical agents via selective drug release when exposed in a magnetic field [35]. Endeavors to create versatile and reliable delivery systems have led to inorganic carriers composed of carbon or silica-conjugates such as siliciumdioxide.…”

Section: Metallic and Inorganic Particlesmentioning

confidence: 99%

Nano drug delivery systems in upper gastrointestinal cancer therapy

et al. 2020

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Upper gastrointestinal (GI) carcinomas are characterized as one of the deadliest cancer types with the highest recurrence rates. Their treatment is challenging due to late diagnosis, early metastasis formation, resistance to systemic therapy and complicated surgeries performed in poorly accessible locations. Current cancer medication face deficiencies such as high toxicity and systemic side-effects due to the non-specific distribution of the drug agent. Nanomedicine has the potential to offer sophisticated therapeutic possibilities through adjusted delivery systems. This review aims to provide an overview of novel approaches and perspectives on nanoparticle (NP) drug delivery systems for gastrointestinal carcinomas. Present regimen for the treatment of upper GI carcinomas are described prior to detailing various NP drug delivery formulations and their current and potential role in GI cancer theranostics with a specific emphasis on targeted nanodelivery systems. To date, only a handful of NP systems have met the standard of care requirements for GI carcinoma patients. However, an increasing number of studies provide evidence supporting NP-based diagnostic and therapeutic tools. Future development and strategic use of NP-based drug formulations will be a hallmark in the treatment of various cancers. This article seeks to highlight the exciting potential of novel NPs for targeted cancer therapy in GI carcinomas and thus provide motivation for further research in this field.

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Magnetic field-assisted selective delivery of doxorubicin to cancer cells using magnetoliposomes as drug nanocarriers

Cited by 31 publications

References 39 publications

Aspects of high-performance and bio-acceptable magnetic nanoparticles for biomedical application

Aspects of high-performance and bio-acceptable magnetic nanoparticles for biomedical application

Titanium and Iron Oxide Nanoparticles for Cancer Therapy: Surface Chemistry and Biological Implications

Nano drug delivery systems in upper gastrointestinal cancer therapy

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