Magnetic Field Enhancement of Antibiotic Activity in Biofilm Forming Pseudomonas aeruginosa

De, Benson; Cb, Grissom; Gl, Burns; Sf, Mohammad

doi:10.1097/00002480-199407000-00025

Cited by 28 publications

(13 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ciprofloxacin significantly eliminates P. aeruginosa biofilms in the presence of static switched magnetic fields Early research conducted in the 1990s suggested the possibility of using magnetic fields as a treatment option to improve the efficiency of antimicrobials on biofilms formed on various medical devices (Khoury et al 1992;Benson et al 1994). Benson et al (1994) reported that the application of static magnetic fields (5-10 G), together with gentamycin, significantly reduced the P. aeruginosa counts on various biomaterial surfaces.…”

Section: Discussionmentioning

confidence: 99%

“…Early investigations explored the possibility of using electromagnetic fields to eliminate P. aeruginosa (Anwar et al 1992;Khoury et al 1992;Benson et al 1994). However, these studies were only conducted on planktonic phases ignoring refractory biofilms, and also failed to meet expected outcomes (Grosman et al 1992;Piatti et al 2002;Potenza et al 2004;Gao et al 2005;Laszlo & Kutasi 2010).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Magnetic fields suppressPseudomonas aeruginosabiofilms and enhance ciprofloxacin activity

et al. 2015

View full text Add to dashboard Cite

Due to the refractory nature of pathogenic microbial biofilms, innovative biofilm eradication strategies are constantly being sought. Thus, this study addresses a novel approach to eradicate Pseudomonas aeruginosa biofilms. Magnetic nanoparticles (MNP), ciprofloxacin (Cipro), and magnetic fields were systematically evaluated in vitro for their relative anti-biofilm contributions. Twenty-four-hour biofilms exposed to aerosolized MNPs, Cipro, or a combination of both, were assessed in the presence or absence of magnetic fields (Static one-sided, Static switched, Oscillating, Static + oscillating) using changes in bacterial metabolism, biofilm biomass, and biofilm imaging. The biofilms exposed to magnetic fields alone exhibited significant metabolic and biomass reductions (p < 0.05). When biofilms were treated with a MNP/Cipro combination, the most significant metabolic and biomass reductions were observed when exposed to static switched magnetic fields (p < 0.05). The exposure of P. aeruginosa biofilms to a static switched magnetic field alone, or co-administration with MNP/Cipro/MNP + Cipro appears to be a promising approach to eradicate biofilms of this bacterium.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Magnetic fields suppressPseudomonas aeruginosabiofilms and enhance ciprofloxacin activity

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Benson et al [1994] investigated an enhancement of the activity of gentamicin against biofilm-forming Pseudomonas aeruginosa adhered on different polymers by using static magnetic fields between 0.5 and 2 mT. They reported an 86% reduction in the number of adhered bacteria when exposed to a 0.5 mT magnetic field in the presence of gentamicin, independent of the colonized biomaterial.…”

Section: Discussionmentioning

confidence: 99%

“…Formed hydroxyl and oxygen radicals are known to destroy cell membranes of bacteria and may be present with the application of an electromagnetic field combined with an EF. This so-called bioelectric effect [Benson et al, 1994;Costerton et al, 1994;McLeod et al, 1999;Pickering et al, 2003] may facilitate the penetration of antibiotic drugs and could be an explanation for the detected advancement of gentamicin.…”

Section: Discussionmentioning

confidence: 99%

Augmentation of antibiotic activity by low-frequency electric and electromagnetic fields examining Staphylococcus aureus in broth media

Matl

Obermeier

Zlotnyk

et al. 2011

Bioelectromagnetics

View full text Add to dashboard Cite

Systemic treatment of biomaterial-associated bacterial infections with high doses of antibiotics is an established therapeutic concept. The purpose of this in vitro study was to determine the influence of magnetic, electromagnetic, and electric fields on gentamicin-based, antibiotic therapy. It has been previously reported that these fields are successful in the treatment of bone healing and reducing osteitis in infected tibia-pseudarthroses. Four separate experimental setups were used to expose bacterial cultures of Staphylococcus aureus both in Mueller-Hinton broth (MHB) and on Mueller-Hinton agar (MHA), in the presence of gentamicin, to (1) a low-frequency magnetic field (MF) 20 Hz, 5 mT; (2) a low-frequency MF combined with an additional alternating electric field (MF + EF) 20 Hz, 5 mT, 470 mV/cm; (3) a sinusoidal alternating electric field (EF AC) 20 Hz, 470 mV/cm; and (4) a direct current electric field (EF DC) 588 mV/cm. No significant difference between samples and controls was detected on MHA. However, in MHB each of the four fields applied showed a significant growth reduction of planktonically grown Staphylococcus aureus in the presence of gentamicin between 32% and 91% within 24 h of the experiment. The best results were obtained by a direct current EF, decreasing colony-forming units (CFU)/ml more than 91%. The application of electromagnetic fields in the area of implant and bone infections could offer new perspectives in antibiotic treatment and antimicrobial chemotherapy.

show abstract

“…The application of static magnetic fields (5 Gauss) may enhance the activity of gentamicin against biofilm-forming Pseudomonas aeruginosa adherent to a polymer substrate (Benson et al 1994).…”

Section: Introductionmentioning

confidence: 99%

Static magnetic field increases the sensitivity of Salmonella to gentamicin

et al. 2010

View full text Add to dashboard Cite

The present study was carried out to evaluate the effects of static magnetic field (SMF) on antibiotic sensitivity of Salmonella enterica subsp. enterica serovar Hadar. We have evaluated antibiotic susceptibility using the disc diffusion method following exposure to SMF. Our results showed that exposure to a 200-mT SMF static magnetic field increased the efficiency (p<0.01) of gentamicin against Salmonella Hadar but did not affect the diameter of the inhibition zone of some other antibiotics actives on Enterobacteria: penicillin, oxacillin, cephalotin, neomycin, amikacin, tetracyclin, erythromycin, spiramycin, chloramphenicol, nalidixic acid and vancomycin.

show abstract

Magnetic Field Enhancement of Antibiotic Activity in Biofilm Forming Pseudomonas aeruginosa

Cited by 28 publications

References 0 publications

Magnetic fields suppressPseudomonas aeruginosabiofilms and enhance ciprofloxacin activity

Magnetic fields suppressPseudomonas aeruginosabiofilms and enhance ciprofloxacin activity

Augmentation of antibiotic activity by low-frequency electric and electromagnetic fields examining Staphylococcus aureus in broth media

Static magnetic field increases the sensitivity of Salmonella to gentamicin

Contact Info

Product

Resources

About