Magnetic Field-Guided MoS₂/WS₂ Heterolayered Nanofilm Regulates Cell Behavior and Gene Expression

Abstract

Using nanomaterials to manipulate the biological activities of cells has generated exciting prospects in materials science and cell biology research. However, the promotion and application of nanomaterials in these fields remain challenging due to issues such as low operability and the induction of adverse events by invasive nanoparticles. Here, we propose an approach to regulate cell behavior by combining a noninvasive n−n heterostructure MW (MoS 2 /WS 2 ) nanofilm with an external magnetic field. Cells seeded on these heterogeneous nanofilms exhibit a stretching phenotype with many more antennas and quicker migration (>1.9 times) than those seeded on homogeneous nanofilms. A magnetic field reverses the cell behavior (e.g., growth, adhesion, migration, and morphology) on heterogeneous nanofilms. Proteins related to cell adhesion and migration contribute to the above reversal. These findings boost the development of cell culture in biomedical research and therapeutic applications, especially in minimally invasive or nondamaging tissue engineering.

Interaction of graphene and WS2with neutrophils and mesenchymal stem cells: implications for peripheral nerve regeneration

“…62 TMDs have also been combined with a non-invasive external magnetic field to stimulate mechanosensitive proteins and signaling pathways to remotely regulate cell behavior. 68…”

“…62 TMDs have also been combined with a non-invasive external magnetic field to stimulate mechanosensitive proteins and signaling pathways to remotely regulate cell behavior. 68 Despite the significant interest in using graphene and TMDs for neural interfaces, 69 so far their interaction with cells different from neurons and Schwann cells in the context of peripheral nerve regeneration has been scarcely unravelled, especially concerning the one synthesized by CVD. Yet, to achieve an optimal pro-regenerative performance of 2D material-based conduits, the interaction of the 2D material with the different cell types involved in peripheral nerve injury needs to be understood.…”

Biocompatibility of NbTaTiVZr with Surface Modifications for Osteoblasts

“…Ideal alloys with enhanced mechanical and chemical properties, including a moderate elastic modulus, better wear, and corrosion resistance, have attracted attention as biomedical implants. , The bioalloy design has been widely investigated. Surface modifications, including nanograined, immersion, etching, dealloying, and coating, have been introduced one after another to enhance the degradation resistance and biocompatibility. − A new generation of multicomponent materials, called high-entropy alloys (HEAs), has been developed to meet such demands in the biomedical field. With an approximately equiatomic ratio of multiple elemental components to increase the configurational entropy, the complicated blend of different atomic elements in HEAs could cause the formation of solid solutions, which have an obviously distorted lattice inside and strengthened mechanical properties. − Because of its nearly equiatomic ratio nature, the constituent elements of HEAs might be decisive in the microstructure and biocompatibility, which makes them new metallic biomaterials (denoted as bio-HEAs).…”