Magnetic-field measurement and simulation of a field-free line magnetic-particle scanner

Abstract

Abstract:In 2005, B. Gleich and J. Weizenecker initially presented the tracer based medical imaging modality Magnetic Particle Imaging (MPI). It uses the nonlinear magnetization behavior of super paramagnetic iron oxide nanoparticles (SPIONs). MPI has the potential to perform real-time imaging in the sub millimeter-range without the use of harmful radiation. To acquire a particle signal from the tracer, an alternating homogenous magnetic field (drive field) is applied. Due to the nonlinearity of the particle magnetization, the magnetic field is distorted and higher harmonics are generated that indicate a particle concentration within the field of view (FOV). For the spatial distribution, another magnetic field that exhibits a high gradient (selection field) is applied simultaneously. Basically, there are two different types of selection fields containing either a fieldfree point (FFP) or a field-free line (FFL). Because of magnetic saturation, only SPIONs within the close vicinity of the FFP or FFL contribute to the particle signal. As the FFP is moved by the drive field through the FOV a spatial distribution of the SPIONs can be obtained. In the other encoding concept, the FFL rotates and is additionally translated by the drive field to obtain one dimensional projections for various angles. In this work, the currently world's largest FFL MPI Scanner is investigated. Single components of the generated magnetic field are measured precisely to accomplish an accurate simulation of a translating and rotating FFL.