Magnetic field pattern synthesis and its application in targeted drug delivery: Design and implementation

Abstract

In cancer therapy, magnetic drug targeting is considered as an effective treatment to reduce chemotherapy's side effects. The accurate design and shaping of magnetic fields are crucial for healthy cells to be immune from chemotherapeutics. In this paper, arbitrary 2-dimensional spatial patterns of magnetic fields from DC to megahertz are represented in terms of spatial Fourier spectra with sinusoidal eigenfunctions. Realization of each spatial frequency was investigated by a set of elliptical coils. Therefore, it is shown that the desired pattern was synthesized by simultaneous use of coil sets. Currents running on each set were obtained via fast and straightforward analytical Fourier series calculation. Experimentally scanned sample patterns were in close agreement with full wave analysis. Discussions include the evaluation of the Fourier series approximation error and cross-polarization of produced magnetic fields. It was observed that by employing the controlled magnetic field produced by the proposed setup, we were able to steer therapeutic particles toward the right or left half-spheres of the breast, with an efficiency of 90%. Such a pattern synthesizer may be employed in numerous human arteries as well as other bioelectromagnetic patterning applications, e.g., wireless power transfer, magnetic innervation, and tomography. Bioelectromagnetics. 39:325-338, 2018. © 2018 Wiley Periodicals, Inc.

Use of magnetic fields and nanoparticles to trigger drug release and improve tumor targeting

“…Because magnetic fields preferentially pass through susceptible materials like steel, by applying a strong magnetic field to a steel yoke and tapering the steel, it is possible to generate strong gradients at the tip of the steel device for magnetic targeting (Voronin et al, ). As an alternative to permanent magnets, it is also possible to use electromagnetic coils that can be preferentially switched on, to generate complex patterned fields for greater spatial control of magnetic drug targeting (Hajiaghajani & Abdolali, ). However, while these methods are able to achieve strong magnetic gradients for targeting, they still tend to localize particles near the device, and therefore continue to be limited to use for drug targeting to surface regions.…”

A review on the use of magnetic fields and ultrasound for non-invasive cancer treatment

“…However, hyperthermia created via Brownian relaxation appears to be more effective in inhibiting tumor growth due to its high heat generation capacity compared to Néel relaxation. Further, Hajiaghajani et al [49] evaluated the importance of design and shaping of magnetic fields in enhancing the efficiency of these treatments, while simultaneously improving the immunity of healthy cells toward chemotherapeutic drugs. They proposed triangular magnetic fields which exhibited up to 90% target efficiency in axillary artery of breast tissues.…”

A Vascular Thrombus Therapy Method Based on Magnetic‐Induced Vibration

“…In recent years, manufacturing technology of magnetostrictive materials has made great breakthroughs, and magnetostrictive materials with better performance can be produced. It has been found that the vibration frequency and vibration intensity of magnetostrictive materials can be controlled by magnetic fields [Li et al, ; Hajiaghajani and Abdolali, ; Poutala et al, ]. The vibration frequency of magnetostrictive materials can reach kHz, which is similar to what is required for a robot to treat thrombus.…”