Magnetic fluid hyperthermia (MFH): Cancer treatment with AC magnetic field induced excitation of biocompatible superparamagnetic nanoparticles

Monodisperse Magnetite Nanoparticles Coupled with Nuclear Localization Signal Peptide for Cell‐Nucleus Targeting

“…[1][2][3][4] Targeted magnetic nanoparticles can be used to enhance the tissue contrast in magnetic resonance imaging (MRI), [5,6] to improve the efficiency in anticancer drug delivery, [7,8] and to eliminate tumor cells by magnetic fluid hyperthermia. [9][10][11] Recent synthetic progress makes it possible to produce mono disperse iron oxide nanoparticles with controlled sizes and magnetic properties, [12][13][14][15] but interactions between these nanoparticles and biomolecular entities, especially various tumor cells, are rarely studied owing to the challenge in nanoparticle functionalization and stabilization. [6,16] Herein we report a robust surface-functionalization approach to link monodisperse Fe 3 O 4 nanoparticles with nuclear localization signal (NLS) peptide and test their capability in targeting tumor-cell nuclei.…”

Influence of dipolar interactions on hyperthermia properties of ferromagnetic particles

“…1 Since then, in vitro experiments with magnetic fluids have confirmed their excellent power absorption capabilities. 2 In vivo experiments have documented the feasibility of this treatment in animal models of melanoma, 3 breast tumors, 4 and prostate cancer. 5 Depending on the applied temperature and the duration of heating this treatment either results in direct tumor cell killing or makes the cells more susceptible to concomitant radio-or chemotherapy, thus increasing therapeutic efficiency.…”

Decreasing nanofluid droplet heating time with alternating magnetic fields

“…Since its first use on the mid 1960s, on the control of the flux of fuel under microgravity conditions, several others applications have appeared, as for instance, heat controlled devices through the use of thermomagnetic convection, for example, liquid-cooled loudspeakers 9 and high power transformers, 10,11 stem cell labeling, and the diagnosis of diseases, since the nanoparticles are good contrast agents for nuclear magnetic resonance imaging, 12 or oncological treatment through the phenomena of magnetic hyperthermia. 13,14 Magnetic hyperthermia consists of the increase in temperature of magnetic fluids due to their response to an alternating magnetic field. Through the use of the first law of thermodynamics, Debye relaxation model and the magnetization equation of motion ‫ץ‬M / ‫ץ‬t = ͑M 0 − M͒ / t m , Rosensweig 8 was able to derive an expression for the nanofluid power dissipation, which was found to be…”