Magnetic Fluid Hyperthermia Modeling Based on Phantom Measurements and Realistic Breast Model

Abstract

Magnetic fluid hyperthermia (MFH) is a minimally invasive procedure that destroys cancer cells. It is based on a superparamagnetic heat phenomenon and consists in feeding a ferrofluid into a tumor, and then applying an external electromagnetic field, which leads to apoptosis. The strength of the magnetic field, optimal dose of the ferrofluid, the volume of the tumor and the safety standards have to be taken into consideration when MFH treatment is planned. In this study, we have presented the novel complementary investigation based both on the experiments and numerical methodology connected with female breast cancer. We have conducted experiments on simplified female breast phantoms with numerical analysis and then we transferred the results on an anatomically-like breast model.

A Thermofluid Analysis of the Magnetic Nanoparticles Enhanced Heating Effects in Tissues Embedded with Large Blood Vessel during Magnetic Fluid Hyperthermia

“…In order to validate the same numerical model with the experimental studies, further results have been compared taking into consideration the experimental data. Figure 10(b) represents the variation of radial temperature distribution, when compared with the present simulation result and the experimental data from Miaskowski and Sawicki [31], where the temperature field is measured inside a tumor located inside a simplified female breast phantom. The comparison shows quite a good agreement with our numerical result.…”

Physical mechanism and modeling of heat generation and transfer in magnetic fluid hyperthermia through Néelian and Brownian relaxation: a review

“…In the presence of blood flow, the increase of temperature is nonlinear due to the heat loss and its rate of temperature rise is decreasing until it reaches the steady state. Therefore, the bioheat transfer model is established to take into account the heat loss term due to the blood flow for describing heat transfer in biological tissue [124–126]. …”

“…Nabil et al [141] showed the effect of blood flow and capillary on the distribution of nanoparticles and the temperature distribution generated. Miaskowski and Sawicki implemented FEM to mimic a more realistic heat transfer in the biological tissue by taking into consideration effects of metabolic heat, blood perfusion, and convection skin cooling [126]. Their study simulated the hyperthermia in breast cancer and showed that the proposed model could potentially be used to provide an accurate temperature mapping of MFH.…”

Numerical Analysis of Electromagnetically Induced Heating and Bioheat Transfer for Magnetic Fluid Hyperthermia

“…For our model frequency, the magnetic field strength is 5518 A/m. The parameters used to calculate the heat dissipation of the nanoparticles are adapted from [15] and [16] and gathered in Table II.…”