Magnetic-fluorescent nanoliposomes decorated with folic acid for active delivery of cisplatin and gemcitabine to cancer cells

Goli, Pooneh Pakdaman; Torbati, Maryam Bikhof; Parivar, Kazem; Khiavi, Azim Akbarzadeh; Yousefi, Mohammad

doi:10.1016/j.procbio.2021.08.007

Cited by 5 publications

(2 citation statements)

References 54 publications

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“…[21,22,23] Moreover, in active tumor targeting, conjugating folic acid and anti-FR antibodies with nanocarriers can considerably raise the internalization efficiency of nanocarriers by cancer cells via folate receptor-mediated endocytosis. [24,25] In this strategy, the cellular uptake of nanocarriers can increase by ten-fold compared with non-targeted drug delivery systems and administration of pure chemotherapeutics. [26] In this study, we applied functionalized fluorescent GQDs as a new selective drug delivery system for targeting of tamoxifen anticancer agent to folate and estrogen receptor positive breast cancer cells with simultaneously applicable in detect, tracing and treatment.…”

Section: Introductionmentioning

confidence: 99%

“…PEGylation of nanoparticles can not only facilitate the passive targeting of cancer cells but also increase their hydrophilicity, avoid the immune system response, and increase the circulation time of nano‐complex in body serum [21,22,23] . Moreover, in active tumor targeting, conjugating folic acid and anti‐FR antibodies with nanocarriers can considerably raise the internalization efficiency of nanocarriers by cancer cells via folate receptor‐mediated endocytosis [24,25] . In this strategy, the cellular uptake of nanocarriers can increase by ten‐fold compared with non‐targeted drug delivery systems and administration of pure chemotherapeutics [26] …”

Section: Introductionmentioning

confidence: 99%

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Efficient and Traceable Tamoxifen Delivery to Breast Cancer Cells Using Folic Acid‐Decorated and PEGylated Graphene Quantum Dots

Amraee,

Torbati,

Majd

et al. 2023

ChemistrySelect

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Graphene quantum dots (GQDs) possess potential properties for the targeted transport and tracking of anticancer medication to tumor cells. For this purpose, the synthesized GQDs were decorated with folic acid (FA) and methoxy polyethylene glycol (mPEG2000), and finally loaded with tamoxifen (TMX) drug. The synthesized nano‐drug was characterized using FTIR, XRD, UV‐Vis, PL, HRTEM, FESEM, and DLS analytical devices. Based on the obtained data, the average hydrodynamic diameter of particles dissolved in water was 294.7 nm and the size of dehydrated particles was between 53 and 210 nm. PL data showed that prepared nanoparticles have an emission wavelength of 438 nm, which is in the blue fluorescent wavelength range, thus making these nanoparticles suitable for cell imaging. The encapsulation efficiency and loading percentage of tamoxifen in nanoparticles were calculated at about 52.5 % and 30 %, respectively, and cumulative drug release reached 89 % within 42 hours. The cytotoxicity effects of nanoparticles were investigated. According to IC50 results, the targeted mPEG‐GQDs‐FA/TMX (TMX‐FPGs) nano‐drug was more toxic than free TMX on MCF‐7 cells and had reduced side effects on healthy HDF cells. TMX‐FPGs induced apoptosis cell death, significantly. The confocal imaging experiments showed that TMX‐FPGs are appropriate for monitoring and targeting MCF‐7 cells.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficient and Traceable Tamoxifen Delivery to Breast Cancer Cells Using Folic Acid‐Decorated and PEGylated Graphene Quantum Dots

Amraee,

Torbati,

Majd

et al. 2023

ChemistrySelect

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Ligand conjugated lipid‐based nanocarriers for cancer theranostics

Kumar

Dkhar

Kumari

et al. 2022

Biotech & Bioengineering

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Cancer is one of the major health‐related issues affecting the population worldwide and subsequently accounts for the second‐largest death. Genetic and epigenetic modifications in oncogenes or tumor suppressor genes affect the regulatory systems that lead to the initiation and progression of cancer. Conventional methods, including chemotherapy/radiotherapy/appropriate combinational therapy and surgery, are being widely used for theranostics of cancer patients. Surgery is useful in treating localized tumors, but it is ineffective in treating metastatic tumors, which spread to other organs and result in a high recurrence rate and death. Also, the therapeutic application of free drugs is related to substantial issues such as poor absorption, solubility, bioavailability, high degradation rate, short shelf‐life, and low therapeutic index. Therefore, these issues can be sorted out using nano lipid‐based carriers (NLBCs) as promising drug delivery carriers. Still, at most, they fail to achieve site‐targeted drug delivery and detection. This can be achieved by selecting a specific ligand/antibody for its cognate receptor molecule expressed on the surface of the cancer cells. In this review, we have mainly discussed the various types of ligands used to decorate NLBCs. A list of the ligands used to design nanocarriers to target malignant cells has been extensively undertaken. The approved ligand‐decorated lipid‐based nanomedicines with their clinical status have been explained in tabulated form to provide a wider scope to the readers regarding ligand‐coupled NLBCs.

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Kappa Carrageenan/PEG-halloysite nanocomposites: Surface characterization with an artificial intelligence technique, antimicrobial, and anticancer properties

Karahan

Tan

Danışman-Kalındemirtaş

et al. 2022

Journal of Drug Delivery Science and Technology

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Magnetic-fluorescent nanoliposomes decorated with folic acid for active delivery of cisplatin and gemcitabine to cancer cells

Cited by 5 publications

References 54 publications

Efficient and Traceable Tamoxifen Delivery to Breast Cancer Cells Using Folic Acid‐Decorated and PEGylated Graphene Quantum Dots

Efficient and Traceable Tamoxifen Delivery to Breast Cancer Cells Using Folic Acid‐Decorated and PEGylated Graphene Quantum Dots

Ligand conjugated lipid‐based nanocarriers for cancer theranostics

Kappa Carrageenan/PEG-halloysite nanocomposites: Surface characterization with an artificial intelligence technique, antimicrobial, and anticancer properties

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