Magnetic Helical Hydrogel Motor for Directing T Cell Chemotaxis

Wang, Zhen; Fu, Dongmei; Xie, Dazhi; Fu, Shuyu; Wu, Juanyan; Wang, Shuanghu; Wang, Fei; Ye, Yicheng; Tu, Yingfeng; Peng, Fei

doi:10.1002/adfm.202101648

Cited by 37 publications

(34 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Discussionmentioning

confidence: 99%

“…The porous hydrogel structure of Polyvinyl alcohol (PVA) provides sufficient sites for high loading and retention of chemokine release. [ 16 ] These MNMs can be driven by a rotating magnetic field to precisely reach the target patient site and send chemokine signals to immune follower cells, leading to T cell chemotaxis or aggregation at the site of chemokine release (Figure 13C). In addition, chemotactic MNMs can be used for in vitro gene delivery and culture delivery of human embryonic kidney (HEK) 293 cells.…”

Section: Biological Application Of Tactic Micro/nanomotorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…C) Scheme of the preparation of PVA@Fe 3 O 4 @CXCL12 hydrogel motor and the directed T cell chemotaxis with the wirelessly manipulated motors. Reproduced with permission [16]. Copyright 2021, Wiley-VCH GmbH.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Micro‐Nano Motors with Taxis Behavior: Principles, Designs, and Biomedical Applications

Gao

Feng

Wilson

et al. 2022

Small

Self Cite

View full text Add to dashboard Cite

As a novel mobile nanodevice, micro‐nano motors (MNMs) can convert the energy of the surrounding environment into mechanical motion. With this unique ability, they promise revolutionary potential in bio‐applications including precise drug delivery, bio‐sensing, and noninvasive surgery. Yet for practically reaching the target and fulfilling these tasks in dynamically changing bio‐environment, environment adaptivity beyond propulsion is important yet challenging. MNMs with taxis behavior/autonomous target‐seeking ability offer a desirable solution. These motors can adaptively move to the target location and complete the task. Thanks to the persistent efforts of researchers, tactic MNMs have shown automatic navigation to target under various energy fields, not only in static environments, but also in shear rheological conditions that simulate blood flow. Therefore, tactic motors with self‐targeting capability lay a concrete foundation for targeted drug delivery, cell transplantation, and thrombus ablation. This review systematically presents the moving principle, design, and biological applications of tactic MNMs under different energy fields. Through in‐depth analysis of state‐of‐art progress, the obstacles of the field and possible solutions are discussed. With the continuous innovation and breakthroughs of multi‐disciplinary researchers, MNMs with taxis behavior are expected to provide a revolutionary solution for cancer and other major diseases in the biomedical field.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Biological Application Of Tactic Micro/nanomotorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Micro‐Nano Motors with Taxis Behavior: Principles, Designs, and Biomedical Applications

Gao

Feng

Wilson

et al. 2022

Small

Self Cite

View full text Add to dashboard Cite

show abstract

“…ImageJ software (Nation Institutes of Health, Bethesda, MD, USA) was used to analyze the pore size and distribution through SEM images. 37,38 2.4. Compressive Modulus Test.…”

Section: Cross-sectional Morphologymentioning

confidence: 99%

Mammalian and Fish Gelatin Methacryloyl–Alginate Interpenetrating Polymer Network Hydrogels for Tissue Engineering

Choi

Jang

et al. 2021

ACS Omega

View full text Add to dashboard Cite

Gelatin methacryloyl (GelMA) has been widely studied as a biomaterial for tissue engineering. Most studies focus on mammalian gelatin, but certain factors, such as mammalian diseases and diet restrictions, limit the use of mammalian gelatin. Thus, fish gelatin has received much attention as a substitute material in recent years. To develop a broadly applicable hydrogel with excellent properties, an interpenetrating polymer network (IPN) hydrogel was synthesized, since IPN hydrogels consist of at least two different hydrogel components to combine their advantages. In this study, we prepared GelMA using type A and fish gelatin and then synthesized IPN hydrogels using GelMA with alginate. GelMA singlenetwork hydrogels were used as a control group. The favorable mechanical properties of type A and fish hydrogels improved after the synthesis of the IPN hydrogels. Type A and fish IPN hydrogels showed different mechanical properties (mechanical strength, swelling ratio, and degradation rate) and different cross-sectional morphologies, since the degree of mechanical enhancement in fish IPN hydrogels was less than that in type A; however, the cell biocompatibilities were not significantly different. Therefore, these findings could serve as a reference for future studies when selecting GelMA as a biological material for tissue engineering.

show abstract

On Nanomachines and Their Future Perspectives in Biomedicine

Ramos-Docampo

2023

Advanced Biology

View full text Add to dashboard Cite

in time, as pointed out by the "Scallop theorem." [1] This means that asymmetry has to present, either as part of the design of the motors or by creating a gradient of matter in the environment. Nanomotors have been widely explored in the last years after being first introduced in the late 90's. Pioneering groups in the field have envisioned these nanomaterials as capable of the most intricate tasks, such as detecting and fighting malignant diseases, nanosurgery, or cleaning clogged arteries. Some of these idealistic scenarios are unfortunately still far to be accomplished. Nonetheless, many challenges predicted more than 10 years ago have already been solved, contributing to great advances in the field of nanomotors, including the use of multiple enzymes to produce locomotion by cascade reactions that would overcome the low-speed motion of single-enzyme-powered motors (vs the use of highly toxic, inorganic catalysts), fast locomotion in nonliquid environments (e.g., gels, cellulose, instead of low-viscous, aqueous media) that better resemble the extracellular matrix or body fluids, or implementation of the motors in cells and animal models (and not only in microfluidic channels) toward future applications in biomedicine, such as drug delivery and diagnosis. Despite the fast progression of the area and the vast possibilities these nanomachines offer, many open questions still need to be answered. For instance, will nanomotors be able to accomplish equally sophisticated tasks as biological motors? Will energy conversion efficiency in the nanomotors compare to that of molecular machines? What are the limits in terms of power/thrust that nanomotors can attain? Will nanomotors be able to cooperate and make collective decisions toward a specific task, i.e., transporting heavy cargo or overcoming physical obstacles?In this Perspective, the evolution of nano/micromotors in biomedicine will be examined (Scheme 1). First, an overview of the classical mechanisms of motion together with the most advanced methods will be provided. Second, the mobility performance of different kind of motors will be discussed, with special emphasis in their improvement from simple media to more complex environments and finally cells and in vivo models. In addition, the challenges and opportunities in the field will be highlighted, with focus on swarms of nanomotors, theoretical models, and the crossing of biological membranes. Eventually, an outlook and future perspective of the field will be outlined, pointing out selected innovative solutions.Nano/micromotors are a class of active matter that can self-propel converting different types of input energy into kinetic energy. The huge efforts that are made in this field over the last years result in remarkable advances. Specifically, a high number of publications have dealt with biomedical applications that these motors may offer. From the first attempts in 2D cell cultures, the research has evolved to tissue and in vivo experimentation, where motors show promising results. In this Perspective, ...

show abstract

Magnetic Helical Hydrogel Motor for Directing T Cell Chemotaxis

Cited by 37 publications

References 32 publications

Micro‐Nano Motors with Taxis Behavior: Principles, Designs, and Biomedical Applications

Micro‐Nano Motors with Taxis Behavior: Principles, Designs, and Biomedical Applications

Mammalian and Fish Gelatin Methacryloyl–Alginate Interpenetrating Polymer Network Hydrogels for Tissue Engineering

On Nanomachines and Their Future Perspectives in Biomedicine

Contact Info

Product

Resources

About